A simple p53 functional assay for screening cell lines, blood, and tumors.

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

p53 Status and the Efficacy of Cancer Therapy in Vivo

1994 • 1,483 citations

Identification of p53 as a Sequence-Specific DNA-Binding Protein

1991 • 1,109 citations

The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins

1990 • 834 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

Molecular Diagnosis of Familial Adenomatous Polyposis

1993 • 588 citations

The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots.

1993 • 512 citations

Sequence-specific transcriptional activation is essential for growth suppression by p53.

1994 • 412 citations

Premature translational termination triggers mRNA decapping

1994 • 399 citations

Analysis of the p53 gene and its expression in human glioblastoma cells.

1994 • 329 citations

The rapid detection of unknown mutations in nucleic acids

1993 • 320 citations

Prevalence and Spectrum of Germline Mutations of the p53 Gene among Patients with Sarcoma

1992 • 304 citations

Screening patients for heterozygous p53 mutations using a functional assay in yeast

1993 • 236 citations

The ADE2 gene from Saccharomyces cerevisiae: sequence and new vectors

1990 • 221 citations

Mammalian p53 can function as a transcription factor in yeast

1992 • 182 citations

Germline p53 Gene Mutations in Subsets of Glioma Patients

1994 • 133 citations

Phosphorothioate primers improve the amplification of DNA sequences by DNA polymerases with proofreading activity

1992 • 119 citations

A rapid PCR fidelity assay

1994 • 118 citations

Detection of Novel Germ-line p53 Mutations in Diverse-Cancer-Prone Families Identifiled by Selecting Patients With Childhood Adrencortical Carcinoma

1992 • 92 citations

A yeast system for expression of human cystathionine beta-synthase: structural and functional conservation of the human and yeast genes.

1994 • 76 citations

A yeast expression system for human galactose-1-phosphate uridylyltransferase.

1993 • 69 citations

A functional screen for germ line p53 mutations based on transcriptional activation.

1992 • 66 citations

Detection of both mutant and wild-type p53 protein in normal skin fibroblasts and demonstration of a shared 'second hit' on p53 in diverse tumors from a cancer-prone family with Li-Fraumeni syndrome.

1992 • 48 citations

On the expression of the p53 protein in human cancer

1994 • 47 citations

Mammalian p53 can function as a transcription factor in yeast

1992 • 36 citations