Proliferation of mutators in A cell population

The Clonal Evolution of Tumor Cell Populations

1976 • 6,310 citations

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

1993 • 2,884 citations

A short course in bacterial genetics : a laboratory manual and handbook for Escherichia coli and related bacteria

1992 • 2,517 citations

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

1993 • 2,282 citations

Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer

1994 • 2,071 citations

Mutation of a mutL Homolog in Hereditary Colon Cancer

1994 • 1,834 citations

TGFβ signals through a heteromeric protein kinase receptor complex

1992 • 1,519 citations

Mutator phenotype may be required for multistage carcinogenesis.

1991 • 1,327 citations

Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase

1992 • 1,071 citations

Antioncogenes and human cancer.

1993 • 772 citations

Microsatellite instability: marker of a mutator phenotype in cancer.

1994 • 552 citations

The experimental study of tumor progression: a review.

1954 • 522 citations

Genetic changes in the transforming growth factor beta (TGF-beta) type II receptor gene in human gastric cancer cells: correlation with sensitivity to growth inhibition by TGF-beta.

1994 • 431 citations

The mutY gene: a mutator locus in Escherichia coli that generates G.C----T.A transversions.

1988 • 343 citations

BACTERIAL MUTATOR GENES AND THE CONTROL OF SPONTANEOUS MUTATION

1976 • 342 citations

SPONTANEOUS MUTATORS IN BACTERIA: Insights into Pathways of Mutagenesis and Repair

1996 • 254 citations

COMPETITION BETWEEN HIGH AND LOW MUTATING STRAINS OF ESCHERICHIA COLI

1983 • 246 citations

A Factor (or Mutator Gene) Influencing Mutation Rates in Escherichia Coli

1954 • 229 citations

A set of lacZ mutations in Escherichia coli that allow rapid detection of specific frameshift mutations.

1990 • 211 citations

Conditional Mutator Gene in Escherichia coli : Isolation, Mapping, and Effector Studies

1974 • 201 citations

Mutational specificity of a conditional Escherichia coli mutator, mutD5

1974 • 200 citations

TGF-beta 1 is an autocrine-negative growth regulator of human colon carcinoma FET cells in vivo as revealed by transfection of an antisense expression vector.

1992 • 182 citations

The transforming growth factor beta receptors types I, II, and III form hetero-oligomeric complexes in the presence of ligand.

1993 • 181 citations

Inhibition of growth by transforming growth factor-beta following fusion of two nonresponsive human carcinoma cell lines. Implication of the type II receptor in growth inhibitory responses.

1992 • 176 citations

Transient mutators: a semiquantitative analysis of the influence of translation and transcription errors on mutation rates.

1991 • 153 citations

SELECTION FOR HIGH MUTATION RATES IN CHEMOSTATS

1974 • 142 citations

Differential sensitivity of subclasses of human colon carcinoma cell lines to the growth inhibitory effects of transforming growth factor-β1

1989 • 142 citations

Fitness of an Escherichia coli Mutator Gene

1970 • 89 citations

Incidence of mutator strains in Escherichia coli and coliforms in nature

1981 • 87 citations

MUTATOR FACTOR IN SALMONELLA TYPHIMURIUM

1960 • 81 citations

Mutator Gene of Escherichia coli B

1967 • 73 citations

OBSERVATIONS ON TWO TYPES OF GENETIC INSTABILITY IN ESCHERICHIA COLI

1960 • 64 citations

Isolation, Characterization, and Genetic Analysis of Mutator Genes in Escherichia coli B and K-12

1970 • 51 citations

Isolation and characterization of mutator strains of Escherichia coli K-12

1975 • 50 citations

Population changes in continuously growing mutator cultures of Escherichia coli.

1973 • 36 citations

Learning how to suppress cancer

1993 • 34 citations

Selection of a Mutant ofEscherichia coliWhich Has High Mutation Rates

1968 • 24 citations

SELECTION OF RESISTANT STRAINS OF ESCHERICHIA COLI BY ANTIBIOTICS AND ANTIBACTERIAL AGENTS: ROLE OF NORMAL AND MUTATOR STRAINS.

1963 • 19 citations