Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion.

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction

1989 • 3,557 citations

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

1989 • 2,081 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis.

1990 • 1,080 citations

Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form.

1990 • 978 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

p53 functions as a cell cycle control protein in osteosarcomas.

1990 • 774 citations

Wild-type p53 can inhibit oncogene-mediated focus formation.

1989 • 738 citations

Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein.

1991 • 544 citations

Genetic Mechanisms of Tumor Suppression by the Human p53 Gene

1990 • 540 citations

Isolation of human‐p53‐specific monoclonal antibodies and their use in the studies of human p53 expression

1986 • 508 citations

Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53.

1990 • 502 citations

Post-translational regulation of the 54K cellular tumor antigen in normal and transformed cells.

1981 • 491 citations

Methods in clinical chemistry

1987 • 464 citations

Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes.

1990 • 409 citations

Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2.

1990 • 353 citations

Analysis of p53 expression in human tumours: an antibody raised against human p53 expressed in Escherichia coli

1992 • 335 citations

Nuclear Accumulation of p53 Protein Is Mediated by Several Nuclear Localization Signals and Plays a Role in Tumorigenesis

1990 • 328 citations

Two distinct mechanisms regulate the levels of a cellular tumor antigen, p53.

1983 • 313 citations

Genetic basis for p53 overexpression in human breast cancer.

1991 • 287 citations

p53 Functions as a Cell Cycle Control Protein in Osteosarcomas

1990 • 224 citations

Structure and expression of c‐erbB‐2 and EGF receptor genes in inflammatory and non‐inflammatory breast cancer: Prognostic significance

1989 • 197 citations

Constant denaturant gel electrophoresis as a rapid screening technique for p53 mutations.

1991 • 192 citations

Nuclear localization is essential for the activity of p53 protein.

1991 • 190 citations

Protein synthesis required to anchor a mutant p53 protein which is temperature-sensitive for nuclear transport

1991 • 180 citations

Post-Translational Regulation of the 54K Cellular Tumor Antigen in Normal and Transformed Cells

1981 • 177 citations

Evidence that p53 behaves as a tumour suppressor gene in sporadic breast tumours.

1990 • 165 citations

p53 interacts with p34cdc2 in mammalian cells: implications for cell cycle control and oncogenesis.

1990 • 156 citations

Primary chemotherapy in the treatment of inflammatory breast carcinoma: a study of 230 cases from the Institut Gustave-Roussy.

1986 • 146 citations

Induction of growth arrest by a temperature-sensitive p53 mutant is correlated with increased nuclear localization and decreased stability of the protein.

1991 • 142 citations

Proteins controlling the nuclear uptake of NF-κB, Rel and dorsal

1991 • 105 citations

Two Distinct Mechanisms Regulate the Levels of a Cellular Tumor Antigen, p53

1983 • 104 citations

Mutant p53, EGF receptor and c-erbB-2 expression in human breast cancer.

1991 • 92 citations

Involvement of wild-type p53 protein in the cell cycle requires nuclear localization.

1991 • 53 citations

Induction of Growth Arrest by a Temperature-Sensitive p53 Mutant Is Correlated with Increased Nuclear Localization and Decreased Stability of the Protein

1991 • 35 citations