p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts.

Antibodies, a laboratory manual

1989 • 12,929 citations

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

1992 • 4,885 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

1994 • 3,536 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Universal control mechanism regulating onset of M-phase

1990 • 2,882 citations

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

1994 • 2,025 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.

1994 • 1,165 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

Induction of WAF1/CIP1 by a p53-independent pathway.

1994 • 773 citations

Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein.

1991 • 544 citations

Sequence-specific transcriptional activation is essential for growth suppression by p53.

1994 • 412 citations

Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage.

1993 • 334 citations

Evidence for a second cell cycle block at G2/M by p53.

1995 • 306 citations

Growth arrest induced by wild-type p53 protein blocks cells prior to or near the restriction point in late G1 phase.

1992 • 274 citations

Spontaneous abnormalities in normal fibroblasts from patients with Li-Fraumeni cancer syndrome: aneuploidy and immortalization.

1990 • 256 citations

A reversible arrest point in the late G1 phase of the mammalian cell cycle

1990 • 203 citations

Role of the cdc25C phosphatase in G2 arrest induced by nitrogen mustard.

1994 • 89 citations

Introduction of wild-type p53 in a human ovarian cancer cell line not expressing endogenous p53

1994 • 51 citations

Normal cytotoxic response of skin fibroblasts from patients with Li-Fraumeni familial cancer syndrome to DNA-damaging agents in vitro.

1987 • 41 citations

Cell Cycle Regulation of Gene Amplification

1993 • 27 citations

The p53-mediated G₁ checkpoint is retained in tumorigenic rat embryo fibroblast clones transformed by the human papillomavirus type 16 E7 gene and EJ-ras

1995 • 26 citations