Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

1997 • 2,510 citations

p53: puzzle and paradigm.

1996 • 2,363 citations

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1995 • 2,115 citations

Definition of a consensus binding site for p53

1992 • 2,000 citations

Radiation-induced cell cycle arrest compromised by p21 deficiency

1995 • 1,249 citations

p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage.

1995 • 1,114 citations

Regulation of the specific DNA binding function of p53

1992 • 914 citations

Induction of the growth inhibitor IGF-binding protein 3 by p53

1995 • 884 citations

A transcriptionally active DNA-binding site for human p53 protein complexes.

1992 • 729 citations

A p53-Dependent Mouse Spindle Checkpoint

1995 • 668 citations

Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues.

1995 • 593 citations

p53 in growth control and neoplasia

1996 • 488 citations

Small peptides activate the latent sequence-specific DNA binding function of p53

1995 • 444 citations

Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinases

1995 • 334 citations

Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53

1997 • 295 citations

A Mutant p53 That Discriminates between p53-Responsive Genes Cannot Induce Apoptosis

1996 • 283 citations

The p53 tumour suppressor protein is phosphorylated at serine 389 by casein kinase II.

1990 • 277 citations

Differential Activation of Target Cellular Promoters by p53 Mutants with Impaired Apoptotic Function

1996 • 271 citations

The p53 protein is an unusually shaped tetramer that binds directly to DNA.

1993 • 252 citations

A Transcriptionally Active DNA-Binding Site for Human p53 Protein Complexes

1992 • 234 citations

Wild-type p53 adopts a ‘mutant’-like conformation when bound to DNA.

1993 • 199 citations

Regulation of the Sequence-specific DNA Binding Function of p53 by Protein Kinase C and Protein Phosphatases

1995 • 199 citations

Involvement of wild-type p53 in pre-B-cell differentiation in vitro.

1991 • 168 citations

Four p53 DNA-binding domain peptides bind natural p53-response elements and bend the DNA.

1995 • 120 citations

DNA Bending Is Essential for the Site-specific Recognition of DNA Response Elements by the DNA Binding Domain of the Tumor Suppressor Protein p53

1997 • 90 citations

Wild type p53 functions as a control protein in the differentiation pathway of the B-cell lineage.

1993 • 75 citations

Architectural Accommodation in the Complex of Four p53 DNA Binding Domain Peptides with the p21/waf1/cip1 DNA Response Element

1997 • 65 citations

Wild-type p53 gene expression induces granulocytic differentiation of HL-60 cells

1994 • 61 citations

Protein interactions at the carboxyl terminus of p53 result in the induction of its in vitro transactivation potential

1997 • 46 citations