A specific spectrum of p53 mutations in lung cancer from smokers: review of mutations compiled in the IARC p53 database.

p53 Mutations in Human Cancers

1991 • 8,133 citations

Mortality in relation to smoking: 40 years' observations on male British doctors

1994 • 5,782 citations

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

1994 • 3,536 citations

IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans

1980 • 3,166 citations

Preferential Formation of Benzo[ a ]pyrene Adducts at Lung Cancer Mutational Hotspots in P53

1996 • 1,636 citations

Mortality in relation to smoking : 40 years' observations on male British doctors

1994 • 1,474 citations

Mortality in relation to consumption of alcohol: 13 years' observations on male British doctors

1994 • 1,242 citations

The accumulated evidence on lung cancer and environmental tobacco smoke

1997 • 733 citations

Smoking in relation to the death rates of one million men and women.

1966 • 642 citations

IARC Database of p53 gene mutations in human tumors and cell lines: updated compilation, revised formats and new visualisation tools

1998 • 448 citations

DNA adducts : identification and biological significance

1994 • 401 citations

Cytosine methylation determines hot spots of DNA damage in the human P 53 gene

1997 • 335 citations

Mutations of p53 and ras genes in radon-associated lung cancer from uranium miners

1992 • 315 citations

Correlation of DNA adduct levels in human lung with cigarette smoking

1988 • 310 citations

At least one in seven cases of cancer is caused by smoking. Global estimates for 1985

1994 • 282 citations

Hepatocellular Carcinoma: From Gene to Public Health

1997 • 267 citations

Selective targeting of p53 gene mutational hotspots in human cancers by etiologically defined carcinogens.

1991 • 262 citations

Different susceptibility to smoking-induced DNA damage among male and female lung cancer patients

1995 • 247 citations

Smoking and lung cancer : scientific challenges and opportunities.

1994 • 232 citations

Analysis of the most representative tumour-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation.

1994 • 231 citations

IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man

1976 • 223 citations

p53mutations in lung tumours: relationship to gender and lung DNA adduct levels

1996 • 174 citations

Cell Cycle-Dependent Strand Bias for UV-Induced Mutations in the Transcribed Strand of Excision Repair-Proficient Human Fibroblasts but Not in Repair-Deficient Cells

1991 • 169 citations

Smoking and cancer mortality among U.S. veterans: A 26‐year follow‐up

1995 • 167 citations

Slow repair of bulky DNA adducts along the nontranscribed strand of the human p53 gene may explain the strand bias of transversion mutations in cancers

1998 • 167 citations

Benzo[a]pyrene-induced murine skin tumors exhibit frequent and characteristic G to T mutations in the p53 gene.

1993 • 153 citations

SHORT COMMUNICATION: G to A transitions and G to T transversions in codon 12 of the Ki-ras oncogene isolated from mouse lung tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and relati DNA methylating and pyridyloxobutylating agents

1993 • 151 citations

Influence of cigarette smoking on the levels of DNA adducts in human bronchial epithelium and white blood cells

1990 • 151 citations

From gene to carcinogen: a rapidly evolving field in molecular epidemiology.

1991 • 146 citations

The molecular epidemiology of P53 gene mutations in human breast cancer

1997 • 142 citations

The role of individual susceptibility in cancer burden related to environmental exposure.

1996 • 141 citations

Gender comparisons in human lung cancer: analysis of p53 mutations, anti-p53 serum antibodies and C-erbB-2 expression

1995 • 129 citations

Sequence specificity of mutations induced by benzo[a]pyrene-7,8-diol-9,10-epoxide at endogenousaprt gene in CHO cells

1988 • 124 citations

p53 mutations in lung cancers from non-smoking atomic-bomb survivors

1993 • 118 citations

Tobacco and cancer: epidemiology and the laboratory.

1995 • 87 citations

Distribution of p53 and K-ras mutations in human lung cancer tissues

1997 • 57 citations

A dose-response relationship between the frequency of p53 mutations and tobacco consumption in lung cancer patients

1996 • 56 citations

Mutation spectrum of cigarette smoke condensate in Salmonella: comparison to mutations in smoking-associated tumors

1995 • 54 citations

p53 and ras Gene Mutations in Lung Cancer: Implications for Smoking and Occupational Exposures

1995 • 48 citations

Mutagenesis in the P53 gene

1997 • 40 citations

Cigarette smoking and p53 mutations in lung cancer and bladder cancer.

1996 • 37 citations

Benzo[a]pyrene‐induced mutagenesis of p53 hot‐spot codons 248 and 249 in human hepatocytes

1995 • 30 citations

The relationship between the chemical structures and mutagenic specificities of the DNA lesions formed by chemical and physical mutagens

1993 • 29 citations

p53 mutations and occupational exposures in a surgical series of lung cancers.

1996 • 28 citations

Mutational Spectrum of the P53 Tumor Suppressor Gene: Clues to Cancer Etiology and Molecular Pathogenesis

1994 • 24 citations

COMMENTARY: Mutational spectra: from model systems to cancer-related genes

1996 • 16 citations

Mutations and homologous recombination induced in mammalian cells by metabolites of benzo[a]pyrene and 1-nitropyrene.

1987 • 13 citations

Analysis of DNA adducts in smokers' lung and urothelium by 32P-postlabelling: metabolic phenotype dependence and comparisons with other exposure markers.

1993 • 13 citations