Mutant p53 can induce tumorigenic conversion of human bronchial epithelial cells and reduce their responsiveness to a negative growth factor, transforming growth factor beta 1.

p53 Mutations in Human Cancers

1991 • 8,133 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

T antigen is bound to a host protein in SY40-transformed cells

1979 • 2,378 citations

Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

1985 • 2,145 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Transforming growth factor beta

2011 • 1,990 citations

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1979 • 1,830 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life.

1988 • 1,140 citations

Identification of p53 as a Sequence-Specific DNA-Binding Protein

1991 • 1,109 citations

TGF-β stimulation and inhibition of cell proliferation: New mechanistic insights

1990 • 992 citations

p53: oncogene or anti-oncogene?

1990 • 812 citations

Presence of a Potent Transcription Activating Sequence in the p53 Protein

1990 • 811 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

Transformation of human bronchial epithelial cells by infection with SV40 or adenovirus-12 SV40 hybrid virus, or transfection via strontium phosphate coprecipitation with a plasmid containing SV40 early region genes.

1988 • 781 citations

p53 functions as a cell cycle control protein in osteosarcomas.

1990 • 774 citations

Transcriptional Activation by Wild-Type but Not Transforming Mutants of the p53 Anti-Oncogene

1990 • 644 citations

Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation

1991 • 617 citations

TGF-β1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains

1990 • 612 citations

Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation

1989 • 599 citations

Type beta transforming growth factor is the primary differentiation-inducing serum factor for normal human bronchial epithelial cells.

1986 • 570 citations

Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53.

1990 • 502 citations

Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes.

1990 • 409 citations

Transforming growth factor beta 1 suppression of c-myc gene transcription: role in inhibition of keratinocyte proliferation.

1990 • 397 citations

Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication

1991 • 382 citations

p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines.

1991 • 349 citations

Selective inhibition of growth-related gene expression in murine keratinocytes by transforming growth factor beta.

1988 • 324 citations

Activating Mutations for Transformation by p53 Produce a Gene Product That Forms an hsc70-p53 Complex with an Altered Half-Life

1988 • 298 citations

Coordinated regulation of apoptosis and cell proliferation by transforming growth factor beta 1 in cultured uterine epithelial cells.

1991 • 279 citations

Radon and Lung Cancer

1989 • 245 citations

Different Tumor-Derived p53 Mutants Exhibit Distinct Biological Activities

1990 • 245 citations

Growth modulation of mouse keratinocytes by transforming growth factors.

1988 • 242 citations

Immunological evidence for the association of p53 with a heat shock protein, hsc70, in p53-plus-ras-transformed cell lines.

1987 • 237 citations

p53 Functions as a Cell Cycle Control Protein in Osteosarcomas

1990 • 224 citations

The murine p53 protein blocks replication of SV40 DNA in vitro by inhibiting the initiation functions of SV40 large T antigen

1989 • 216 citations

Human bronchial epithelial cells with integrated SV40 virus T antigen genes retain the ability to undergo squamous differentiation

1988 • 188 citations

Differential sensitivity of human colonic adenoma and carcinoma cells to transforming growth factor beta (TGF-beta): conversion of an adenoma cell line to a tumorigenic phenotype is accompanied by a reduced response to the inhibitory effects of TGF-beta.

1991 • 174 citations

Mutant p53 proteins bind DNA abnormally in vitro.

1991 • 166 citations

Mutant p53 proteins bind hsp 72/73 cellular heat shock-related proteins in SV40-transformed monkey cells.

1987 • 162 citations

Alterations in tumor development in vivo mediated by expression of wild type or mutant p53 proteins.

1991 • 131 citations

A potential transcriptional activation element in the p53 protein.

1990 • 129 citations

Strontium phosphate transfection of human cells in primary culture: stable expression of the simian virus 40 large-T-antigen gene in primary human bronchial epithelial cells.

1987 • 101 citations

DNA binding properties of murine p53.

1988 • 100 citations

Wild type human p53 is antiproliferative in SV40-transformed hamster cells.

1990 • 97 citations

Specific interaction between a subset of the p53 protein family and heat shock proteins hsp72/hsc73 in a human osteosarcoma cell line.

1988 • 92 citations

Two distinct regions of the murine p53 primary amino acid sequence are implicated in stable complex formation with simian virus 40 T antigen

1988 • 92 citations

Human p53 oncogene contains one promoter upstream of exon 1 and a second, stronger promoter within intron 1.

1988 • 88 citations

Characterization of mutant p53-hsp72/73 protein-protein complexes by transient expression in monkey COS cells.

1988 • 72 citations

Expression from the murine p53 promoter is mediated by factor binding to a downstream helix-loop-helix recognition motif.

1991 • 67 citations

Transforming growth factor-beta and retinoic acid modulate phenotypic transformation of normal rat kidney cells induced by epidermal growth factor and platelet-derived growth factor.

1986 • 64 citations

Correlated abnormalities of transforming growth factor-β1 response and p53 expression in thyroid epithelial cell transformation

1991 • 63 citations

Selective Inhibition of Growth-Related Gene Expression in Murine Keratinocytes by Transforming Growth Factor β

1988 • 56 citations

Immunological Evidence for the Association of P53 with a Heat Shock Protein, hsc70, in p53-plus-ras-Transformed Cell Lines

1987 • 56 citations

Control of growth and squamous differentiation in normal human bronchial epithelial cells by chemical and biological modifiers and transferred genes.

1989 • 47 citations

Cell density governs the ability of human bronchial epithelial cells to recognize serum and transforming growth factor beta-1 as squamous differentiation-inducing agents.

1990 • 32 citations

Ability of p53 and the adenovirus E1b 58-kilodalton protein to form a complex is determined by p53

1989 • 32 citations

Transforming activity of mutant human p53 alleles

1991 • 19 citations

Cellular and molecular biological aspects of human bronchogenic carcinogenesis

1990 • 11 citations