Structural Aspects of the p53 Protein in Relation to Gene Evolution: A Second Look

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

1994 • 3,536 citations

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

1994 • 2,460 citations

Definition of a consensus binding site for p53

1992 • 2,000 citations

The p53-mdm-2 autoregulatory feedback loop.

1993 • 1,795 citations

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1993 • 1,445 citations

Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life.

1988 • 1,140 citations

Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form.

1990 • 978 citations

The structure and function of proline-rich regions in proteins

1994 • 965 citations

Interaction of the p53-Regulated Protein Gadd45 with Proliferating Cell Nuclear Antigen

1994 • 941 citations

Regulation of the specific DNA binding function of p53

1992 • 914 citations

Induction of the growth inhibitor IGF-binding protein 3 by p53

1995 • 884 citations

p53: oncogene or anti-oncogene?

1990 • 812 citations

Presence of a Potent Transcription Activating Sequence in the p53 Protein

1990 • 811 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3.

1994 • 666 citations

Mapping of the p53 and mdm-2 interaction domains.

1993 • 658 citations

Transcriptional Activation by Wild-Type but Not Transforming Mutants of the p53 Anti-Oncogene

1990 • 644 citations

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein.

1994 • 644 citations

Structural aspects of the p53 protein in relation to gene evolution.

1990 • 618 citations

Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation

1991 • 617 citations

Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation

1989 • 599 citations

TP53 tumor suppressor gene: A model for investigating human mutagenesis

1992 • 584 citations

Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein.

1991 • 544 citations

Crystal Structure of the Tetramerization Domain of the p53 Tumor Suppressor at 1.7 Angstroms

1995 • 533 citations

Wild-type p53 binds to the TATA-binding protein and represses transcription.

1992 • 527 citations

The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots.

1993 • 512 citations

Human DNA-Activated Protein Kinase Phosphorylates Serines 15 and 37 in the Amino-Terminal Transactivation Domain of Human p53

1992 • 473 citations

Complete sequencing of the p53 gene provides prognostic information in breast cancer patients, particularly in relation to adjuvant systemic therapy and radiotherapy

1995 • 458 citations

Detection of antibodies against the cellular protein p53 in sera from patients with breast cancer

1982 • 448 citations

Small peptides activate the latent sequence-specific DNA binding function of p53

1995 • 444 citations

p53 Transcriptional Activation Mediated by Coactivators TAF _II 40 and TAF _II 60

1995 • 438 citations

Sequence-specific transcriptional activation is essential for growth suppression by p53.

1994 • 412 citations

p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches

1995 • 409 citations

Redox modulation of p53 conformation and sequence-specific DNA binding in vitro.

1993 • 406 citations

Inhibition of DNA replication factor RPA by p53

1993 • 380 citations

Multifactorial analysis of p53 alteration in human cancer: A review

1994 • 359 citations

Nuclear and nucleolar targeting sequences of c-erb-A, c-myb, N-myc, p53, HSP70, and HIV tat proteins

1989 • 358 citations

Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2.

1990 • 353 citations

Activation of p53 sequence-specific DNA bindingby short single strands of DNA requires the p53 C-terminus

1995 • 347 citations

Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding.

1992 • 344 citations

Nuclear Accumulation of p53 Protein Is Mediated by Several Nuclear Localization Signals and Plays a Role in Tumorigenesis

1990 • 328 citations

Characterization of the human p53 gene.

1986 • 321 citations

Hepatitis B x antigen and p53 are associated in vitro and in liver tissues from patients with primary hepatocellular carcinoma.

1993 • 307 citations

Role of Cysteine Residues in Regulation of p53 Function

1995 • 301 citations

High-Resolution Structure of the Oligomerization Domain of p53 by Multidimensional NMR

1994 • 300 citations

Isolation and characterization of a human p53 cDNA clone: expression of the human p53 gene.

1984 • 297 citations

Tumour suppressors, kinases and clamps: How p53 regulates the cell cycle in response to DNA damage

1995 • 291 citations

The immune response to p53 in breast cancer patients is directed against immunodominant epitopes unrelated to the mutational hot spot.

1992 • 283 citations

Negative feedback regulation of wild-type p53 biosynthesis.

1995 • 281 citations

The p53 tumour suppressor protein is phosphorylated at serine 389 by casein kinase II.

1990 • 277 citations

A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein.

1993 • 263 citations

Solution structure of the tetrameric minimum transforming domain of p53

1994 • 260 citations

The p53 Activation Domain Binds the TATA Box-Binding Polypeptide in Holo-TFIID, and a Neighboring p53 Domain Inhibits Transcription

1993 • 246 citations

p53 point mutation and survival in colorectal cancer patients.

1995 • 240 citations

Transcriptional activation by p53 correlates with suppression of growth but not transformation

1994 • 237 citations

Immunochemical analysis of the interaction of p53 with MDM2;--fine mapping of the MDM2 binding site on p53 using synthetic peptides.

1994 • 234 citations

Analysis of the most representative tumour-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation.

1994 • 231 citations

Mutant conformation of p53

1992 • 214 citations

Direct interaction between the transcriptional activation domain of human p53 and the TATA box-binding protein.

1993 • 209 citations

A single gene and a pseudogene for the cellular tumour antigen p53

1983 • 208 citations

Domains required for in vitro association between the cellular p53 and the adenovirus 2 E1B 55k proteins

1990 • 207 citations

Regulation of specific DNA binding by p53: evidence for a role for O-glycosylation and charged residues at the carboxy-terminus.

1996 • 203 citations

Wild-type p53 adopts a ‘mutant’-like conformation when bound to DNA.

1993 • 199 citations

Activation of the cryptic DNA binding function of mutant forms of p53

1993 • 190 citations

The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation.

1995 • 188 citations

Two Domains of p53 Interact with the TATA-Binding Protein, and the Adenovirus 13S E1A Protein Disrupts the Association, Relieving p53-Mediated Transcriptional Repression

1995 • 185 citations

Analysis of the gene coding for the murine cellular tumour antigen p53.

1984 • 182 citations

A structural role for metal ions in the "wild-type" conformation of the tumor suppressor protein p53.

1993 • 182 citations

Identification of the p53 protein domain involved in formation of the simian virus 40 large T-antigen-p53 protein complex

1986 • 175 citations

Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53.

1985 • 174 citations

Analysis of p53 antibodies in patients with various cancers define B-cell epitopes of human p53: distribution on primary structure and exposure on protein surface.

1993 • 173 citations

Cloning and characterization of a cDNA from Xenopus laevis coding for a protein homologous to human and murine p53.

1987 • 158 citations

Phosphorylation of the tumor suppressor protein p53 by mitogen-activated protein kinases.

1994 • 154 citations

p53 Domains: Structure, Oligomerization, and Transformation

1994 • 146 citations

Analyses of p53 antibodies in sera of patients with lung carcinoma define immunodominant regions in the p53 protein

1994 • 143 citations

Mutation of the serine 15 phosphorylation site of human p53 reduces the ability of p53 to inhibit cell cycle progression.

1993 • 140 citations

Post-translational modification of p53.

1994 • 140 citations

The p53 nuclear localisation signal is structurally linked to a p34cdc2 kinase motif.

1990 • 135 citations

Presence of circulating antibodies against cellular protein p53 in a notable proportion of children with B-cell lymphoma

1987 • 134 citations

Molecular cloning of a cDNA specific for the murine p53 cellular tumor antigen.

1983 • 128 citations

A temperature-sensitive mutant of human p53.

1994 • 128 citations

The dihedral symmetry of the p53 tetramerization domain mandates a conformational switch upon DNA binding.

1995 • 126 citations

Different forms of p53 detected by monoclonal antibodies in non-dividing and dividing lymphocytes

1984 • 126 citations

Phosphorylation of the p53 tumour-suppressor protein at three N-terminal sites by a novel casein kinase I-like enzyme.

1992 • 121 citations

Immunologically Distinct p53 Molecules Generated by Alternative Splicing

1986 • 120 citations

Human p53 and CDC2Hs genes combine to inhibit the proliferation of Saccharomyces cerevisiae.

1992 • 118 citations

Nucleotide sequence of a cDNA encoding the rat p53 nuclear oncoprotein

1988 • 115 citations

A DNA binding domain is contained in the C-terminus ofwild typep53 protein

1991 • 113 citations

p53 binds to the TATA-binding protein-TATA complex

1993 • 113 citations

Clinical utility of the immunocytochemical detection of p53 protein in cytological specimens.

1994 • 112 citations

Life and death by P53

1995 • 111 citations

Two Distinct Signaling Pathways Activate the Latent DNA Binding Function of p53 in a Casein Kinase II-independent Manner

1995 • 109 citations

The amino acid sequence of murine p53 determined from a c-DNA clone

1984 • 104 citations

The carboxyl-terminal domain of the p53 protein regulates sequence-specific DNA binding through its nonspecific nucleic acid-binding activity.

1995 • 101 citations

Effects of p53 mutants on wild-type p53-mediated transactivation are cell type dependent.

1995 • 101 citations

Human wild-type p53 adopts a unique conformational and phosphorylation state in vivo during growth arrest of glioblastoma cells.

1992 • 99 citations

The human tumour suppressor gene p53 is alternatively spliced in normal cells.

1996 • 98 citations

Two distinct regions of the murine p53 primary amino acid sequence are implicated in stable complex formation with simian virus 40 T antigen

1988 • 92 citations

The 53,000-dalton cellular protein and its role in transformation.

1983 • 91 citations

Phosphorylation at Ser-15 and Ser-392 in mutant p53 molecules from human tumors is altered compared to wild-type p53.

1993 • 91 citations

Flexibility: the key to p53 function?

1995 • 87 citations

Association of casein kinase II with immunopurified p53.

1991 • 86 citations

Structure of the rat p53 tumor suppressor gene

1993 • 86 citations

Cloning and expression analysis of full length mouse cDNA sequences encoding the transformation associated protein p53

1984 • 85 citations

Tissue‐specific expression of p53 in transgenic mice is regulated by intron sequences

1991 • 84 citations

p53 is associated with p34cdc2 in transformed cells.

1990 • 82 citations

Temperature-dependent switching between “wild-type” and “mutant” forms of p53-Val135

1990 • 78 citations

Human p53 inhibits growth in Schizosaccharomyces pombe.

1992 • 78 citations

Rainbow trout p53: cDNA cloning and biochemical characterization

1992 • 74 citations

Phosphorylation sites in the amino-terminal region of mouse p53.

1992 • 74 citations

Mutations in p53 produce a common conformational effect that can be detected with a panel of monoclonal antibodies directed toward the central part of the p53 protein.

1994 • 72 citations

Endogenous p53 protein generated from wild-type alternatively spliced p53 RNA in mouse epidermal cells.

1994 • 71 citations

Conformational changes in p53 analysed using new antibodies to the core DNA binding domain of the protein.

1995 • 71 citations

Interaction of p53 with MDM2 is independent of E6 and does not mediate wild type transformation suppressor function.

1994 • 70 citations

Mutational analysis of the carboxy-terminal portion of p53 using both yeast and mammalian cell assays in vivo.

1995 • 67 citations

Linear antigenic sites defined by the B-cell response to human p53 are localized predominantly in the amino and carboxy-termini of the protein.

1994 • 57 citations

The tumor suppressor p53 is bound to RNA by a stable covalent linkage.

1991 • 56 citations

A conformation hypothesis for the suppressor and promoter functions ofp53in cell growth control and in cancer

1991 • 54 citations

An intron binding protein is required for transformation ability of p53

1991 • 44 citations

Nucleotide sequence of a cDNA encoding the chicken p53 nuclear oncoprotein

1988 • 43 citations

Hsp70 binds specifically to a peptide derived from the highly conserved domain (I) region of P53

1992 • 41 citations

Cloning of feline p53 tumor‐suppressor gene and its aberration in hematopoietic tumors

1994 • 38 citations

Forms and functions of p53.

1994 • 37 citations

p53 in complex with DNA is resistant to ubiquitin-dependent proteolysis in the presence of HPV-16 E6.

1995 • 35 citations

Lymphocyte stimulation: concanavalin A induces the expression of a 53K protein

1980 • 34 citations

Production of human p53 specific monoclonal antibodies and their use in immunohistochemical studies of tumor cells.

1993 • 33 citations

Ability of p53 and the adenovirus E1b 58-kilodalton protein to form a complex is determined by p53

1989 • 32 citations

The cDNA cloning and immunological characterization of hamster p53

1992 • 25 citations

Sequence analysis of canine p53 in the region of exons 3–8

1995 • 25 citations

The rat genome contains a p53 pseudogene: detection of a processed pseudogene using PCR.

1992 • 24 citations

State of the p53 gene in hepatocellular carcinomas of ground squirrels and woodchucks with past and ongoing infection with hepadnaviruses.

1994 • 23 citations

Nucleotide sequence of a cDNA encoding the monkey cellular phosphoprotein p53

1989 • 21 citations

A human tumour-derived mutant p53 protein induces a p34cdc2 reversible growth arrest in fission yeast.

1991 • 16 citations

Alternatively-Spliced p53 mRNA in the FAA-HTC1 Rat Hepatoma Cell Line without the Splice Site Mutations.

1992 • 14 citations

Spot-1, a novel NLS-binding protein that interacts with p53 through a domain encoded by p(CA)n repeats.

1995 • 11 citations

Cloning of the syrian hamster p53 gene: Structural and functional characterization of the upstream promoter region

1994 • 9 citations

Sequence of a cDNA encoding the p53 protein in Rhesus monkey (Macaca mulatta)

1994 • 5 citations