Conditional Mutator Phenotypes in hMSH2-Deficient Tumor Cell Lines

Lessons from Hereditary Colorectal Cancer

1996 • 4,900 citations

MUTATIONS OF BACTERIA FROM VIRUS SENSITIVITY TO VIRUS RESISTANCE

1943 • 3,852 citations

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

1993 • 2,282 citations

Mutations of two P/WS homologues in hereditary nonpolyposis colon cancer

1994 • 1,544 citations

Hypermutability and mismatch repair deficiency in RER+ tumor cells

1993 • 1,042 citations

Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

1994 • 620 citations

Isolation of an hMSH2-p160 Heterodimer That Restores DNA Mismatch Repair to Tumor Cells

1995 • 599 citations

hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6

1996 • 541 citations

GTBP, a 160-Kilodalton Protein Essential for Mismatch-binding Activity in Human Cells

1995 • 528 citations

Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation

1994 • 496 citations

Mutations of GTBP in Genetically Unstable Cells

1995 • 471 citations

23 Genetic instability induced by the tumor microenvironment

1997 • 429 citations

Mutator phenotypes in human colorectal carcinoma cell lines.

1994 • 428 citations

Ouabain-resistant mutants of mouse and hamster cells in culture

1974 • 393 citations

Automated DNA sequencing of the human HPRT locus

1990 • 357 citations

APC mutations in colorectal tumors with mismatch repair deficiency.

1996 • 329 citations

Microsatellite instability, mismatch repair deficiency, and genetic defects in human cancer cell lines.

1995 • 301 citations

Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyl transferase.

1983 • 299 citations

Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer.

1995 • 239 citations

DOSAGE COMPENSATION IN DROSOPHILA

1994 • 235 citations

Isolation and Characterization of a Full-Length Expressible cDNA for Human Hypoxanthine Phosphoribosyltransferase

1983 • 222 citations

Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair

1996 • 181 citations

DNA mismatch binding defects, DNA damage tolerance, and mutator phenotypes in human colorectal carcinoma cell lines.

1995 • 168 citations

The origin of point mutations in human tumor cells.

1992 • 154 citations

A table for the estimation of the spontaneous mutations rate of cells in culture

1973 • 149 citations

Mutation rate at the hprt locus in human cancer cell lines with specific mismatch repair-gene defects

1997 • 148 citations

Genetic instability in human ovarian cancer cell lines.

1994 • 134 citations

Accumulation of multiple mutations in tumour suppressor genes during colorectal tumorigenesis in HNPCC patients

1994 • 96 citations

Differences in the spectrum of spontaneous mutations in the hprt gene between tumor cells of the microsatellite mutator phenotype

1996 • 90 citations

Molecular analysis of mutations in mutator colorectal carcinoma cell lines

1995 • 86 citations

Characterization of an ovarian carcinoma cell line.

1978 • 84 citations

GENETICS OF HEREDITARY COLON CANCER

1995 • 82 citations

Expression of human MutS homolog 2 (hMSH2) protein in resting and proliferating cells.

1996 • 74 citations

Cell cycle regulation of the human DNA mismatch repair genes hMSH2, hMLH1, and hPMS2.

1997 • 66 citations

Microsatellite instability in gynecological sarcomas and in hMSH2 mutant uterine sarcoma cell lines defective in mismatch repair activity.

1995 • 53 citations

Genetics of Hereditary Colon Cancers

1995 • 15 citations