Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia

1996 • 1,467 citations

Role of poly(ADP-ribose) formation in DNA repair

1992 • 1,142 citations

Nitric Oxide Activation of Poly(ADP-Ribose) Synthetase in Neurotoxicity

1994 • 1,138 citations

Poly(ADP-ribose) polymerase: a molecular nick-sensor

1994 • 790 citations

Poly(ADP-Ribose) in the Cellular Response to DNA Damage

1985 • 771 citations

Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease.

1995 • 767 citations

Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression

1991 • 698 citations

Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death.

1996 • 621 citations

scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair.

1991 • 509 citations

ADP-ribosylation of proteins. Enzymology and biological significance.

1987 • 374 citations

Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells.

1993 • 242 citations

Inhibitors of poly(adenosine diphosphate ribose) polymerase induce sister chromatid exchanges

1980 • 236 citations

Structure of the catalytic fragment of poly(AD-ribose) polymerase from chicken.

1996 • 234 citations

ADP-Ribose in DNA Repair: A New Component of DNA Excision Repair

1984 • 226 citations

A dominant-negative mutant of human poly(ADP-ribose) polymerase affects cell recovery, apoptosis, and sister chromatid exchange following DNA damage.

1995 • 200 citations

Zinc-binding domain of poly(ADP-ribose)polymerase participates in the recognition of single strand breaks on DNA

1989 • 192 citations

A simplified technique for in vivo analysis of sister-chromatid exchanges using 5-bromodeoxyuridine tablets

1977 • 181 citations

trans-Dominant Inhibition of Poly(ADP-Ribosyl)ation Sensitizes Cells against γ-Irradiation and N-Methyl-N′-Nitro-N-Nitrosoguanidine but Does Not Limit DNA Replication of a Polyomavirus Replicon

1995 • 113 citations

The human poly(ADP-ribose) polymerase nuclear localization signal is a bipartite element functionally separate from DNA binding and catalytic activity.

1992 • 107 citations

Depletion of nuclear poly(ADP-ribose) polymerase by antisense RNA expression: influences on genomic stability, chromatin organization, and carcinogen cytotoxicity.

1994 • 96 citations

Expression and site-directed mutagenesis of the catalytic domain of human poly(ADP-ribose)polymerase in Escherichia coli. Lysine 893 is critical for activity.

1990 • 85 citations

Detection of poly(ADP ribose) polymerase in crude extracts by activity-blot

1991 • 57 citations

Trans-dominant inhibition of poly(ADP-ribosyl)ation potentiates carcinogen induced gene amplification in SV40-transformed Chinese hamster cells.

1996 • 43 citations

Variations of chromosome radiation sensitivity in fetal and adult mice during gestation

1991 • 15 citations