Absence of WAF1 mutations in a variety of human malignancies

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

1994 • 2,025 citations

Mammalian G1 cyclins

1993 • 1,990 citations

Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

1994 • 1,806 citations

The p53-mdm-2 autoregulatory feedback loop.

1993 • 1,795 citations

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

1994 • 1,475 citations

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1993 • 1,445 citations

Cloning of Senescent Cell-Derived Inhibitors of DNA Synthesis Using an Expression Screen

1994 • 1,368 citations

Allelotype of Colorectal Carcinomas

1989 • 1,333 citations

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

1992 • 871 citations

PCR-SSCP: a simple and sensitive method for detection of mutations in the genomic DNA.

1991 • 780 citations

Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit

1993 • 778 citations

High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas.

1993 • 652 citations

Chromosome Aberrations and Cancer

1991 • 598 citations

Redundant cyclin overexpression and gene amplification in breast cancer cells.

1993 • 526 citations

Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation.

1993 • 514 citations

Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes

1991 • 493 citations

Function of a human cyclin gene as an oncogene.

1994 • 471 citations

Braking the cycle

1993 • 378 citations

Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts.

1993 • 325 citations

Allelotype of human ovarian cancer.

1991 • 257 citations

Human epithelial ovarian cancer allelotype.

1993 • 241 citations

Frequency and structure of p53 rearrangements in human osteosarcoma.

1990 • 199 citations

Amplification of cyclin genes in colorectal carcinomas.

1993 • 197 citations

Analysis of p53 mutations in a large series of lymphoid hematologic malignancies of childhood

1993 • 179 citations

Retrovirus-mediated transgenic keratin expression in cultured fibroblasts: Specific domain functions in keratin stabilization and filament formation

1990 • 165 citations

Allelotype of renal cell carcinoma.

1991 • 141 citations

Human papillomaviruses and cervical cancer: Analysis of histopathologic features associated with different viral types

1988 • 123 citations

How Cells Cycle Toward Cancer

1994 • 117 citations

Carcinoma of the vulva: HPV and p53 mutations.

1994 • 107 citations

Mutation of the p53 gene in neuroblastoma and its relationship with N-myc amplification.

1993 • 90 citations

p53 mutations in HPV-negative cervical carcinoma.

1994 • 84 citations

Mutation and protein expression of p53 in acquired immunodeficiency syndrome-related lymphomas

1993 • 61 citations

p53 mutations and MDM-2 amplification in renal cell cancers.

1994 • 36 citations

Mutations of p53 in Wilms' tumors.

1995 • 27 citations