Effects of p53 mutation on tumor progression: recent insights from mouse tumor models

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

The Clonal Evolution of Tumor Cell Populations

1976 • 6,310 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

Definition of a consensus binding site for p53

1992 • 2,000 citations

Control of Angiogenesis in Fibroblasts by p53 Regulation of Thrombospondin-1

1994 • 1,460 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

Oncogenic forms of p53 inhibit p53-regulated gene expression

1992 • 933 citations

p53-Dependent apoptosis suppresses tumor growth and progression in vivo

1994 • 883 citations

Gain of function mutations in p53

1993 • 876 citations

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

1993 • 875 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice

1988 • 745 citations

Modulation of Activity of the Promoter of the Human MDR 1 Gene by Ras and p53

1992 • 735 citations

A transcriptionally active DNA-binding site for human p53 protein complexes.

1992 • 729 citations

A p53-Dependent Mouse Spindle Checkpoint

1995 • 668 citations

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens

1994 • 617 citations

Wild-type p53 activates transcription in vitro

1992 • 609 citations

Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein.

1991 • 544 citations

Spontaneous and carcinogen–induced tumorigenesis in p53–deficient mice

1993 • 537 citations

In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice.

1993 • 471 citations

Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors

1993 • 465 citations

Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development.

1994 • 406 citations

Growth factor modulation of p53-mediated growth arrest versus apoptosis.

1995 • 377 citations

Multistage carcinogenesis induced by ras and myc oncogenes in a reconstituted organ

1989 • 360 citations

Anaplastic Wilms' tumour, a subtype displaying poor prognosis, harbours p53 gene mutations

1994 • 333 citations

Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells

1994 • 315 citations

Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53.

1994 • 310 citations

Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells.

1994 • 290 citations

Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability.

1995 • 280 citations

Transcriptional activation by p53 correlates with suppression of growth but not transformation

1994 • 237 citations

A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53–deficient mice

1995 • 233 citations

Detection of frequent p53 gene mutations in primary gastric cancer by cell sorting and polymerase chain reaction single-strand conformation polymorphism analysis.

1991 • 230 citations

Fibroblast Growth Factor

1990 • 173 citations

Increased p53 protein content of colorectal tumours correlates with poor survival

1992 • 147 citations

17p allelic losses in diploid cells of patients with Barrett's esophagus who develop aneuploidy.

1994 • 142 citations

Gain-of-function mutations of the p53 gene induce lymphohematopoietic metastatic potential and tissue invasiveness.

1994 • 140 citations

Clonal expansion and attenuated apoptosis in Wilms' tumors are associated with p53 gene mutations.

1995 • 138 citations

Alterations in tumor development in vivo mediated by expression of wild type or mutant p53 proteins.

1991 • 131 citations

Loss of p53 function leads to metastasis in ras+myc-initiated mouse prostate cancer.

1995 • 114 citations

p53 abnormalities and genomic instability in primary human breast carcinomas.

1995 • 108 citations

Testing the Role of p53 in the Expression of Genetic Instability and Apoptosis in Ataxia-telangiectasia

1994 • 101 citations

High Incidence of p53 Gene Mutation in Human Ovarian Cancer and Its Association with Nuclear Accumulation of p53 Protein and Tumor DNA Aneuploidy

1992 • 101 citations

Synergy between a human c-myc transgene and p53 null genotype in murine thymic lymphomas: contrasting effects of homozygous and heterozygous p53 loss.

1995 • 94 citations

Induction of apoptosis by tumor suppressor genes and oncogenes

1995 • 81 citations

GERMLINE p53 MUTATIONS AND HERITABLE CANCER

1994 • 78 citations

Human prostatic inhibin suppresses tumor growth and inhibits clonogenic cell survival of a model prostatic adenocarcinoma, the Dunning R3327G rat tumor.

1993 • 40 citations