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1980 • 15,302 citations

Oxidants, antioxidants, and the degenerative diseases of aging.

1993 • 6,011 citations

ras GENES

1987 • 3,818 citations

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

1994 • 3,536 citations

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

1994 • 2,460 citations

A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma.

1991 • 1,946 citations

Sunburn and p53 in the onset of skin cancer

1994 • 1,501 citations

Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene

1987 • 1,235 citations

DNA repair in an active gene: Removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall

1985 • 1,233 citations

In Vivo Footprinting of a Muscle Specific Enhancer by Ligation Mediated PCR

1989 • 972 citations

DNA REPAIR ENZYMES

1988 • 822 citations

Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers.

1993 • 738 citations

Thymine-Thymine Dimer Bypass by Yeast DNA Polymerase ζ

1996 • 655 citations

THE BIOLOGY OF THE (6–4) PHOTOPRODUCT

1989 • 604 citations

TP53 tumor suppressor gene: A model for investigating human mutagenesis

1992 • 584 citations

Handbook of Biochemistry. Selected Data for Molecular Biology.

1969 • 570 citations

Replication Timing of Genes and Middle Repetitive Sequences

1984 • 561 citations

Aflatoxin B1 induces the transversion of G-->T in codon 249 of the p53 tumor suppressor gene in human hepatocytes.

1993 • 482 citations

Preferential DNA repair of an active gene in human cells.

1986 • 455 citations

DNA repair and aging in basal cell carcinoma: a molecular epidemiology study.

1993 • 419 citations

Genomic Sequencing and Methylation Analysis by Ligation Mediated PCR

1989 • 408 citations

UV-induced mutation hotspots occur at DNA damage hotspots

1982 • 397 citations

MOLECULAR MECHANISMS OF ULTRAVIOLET RADIATION CARCINOGENESIS

1990 • 385 citations

THE RELATIVE CYTOTOXICITY OF(6–4) PHOTOPRODUCTS AND CYCLOBUTANE DIMERS IN MAMMALIAN CELLS*

1988 • 353 citations

X-chromosome inactivation and cell memory

1992 • 329 citations

UV and skin cancer: specific p53 gene mutation in normal skin as a biologically relevant exposure measurement.

1994 • 324 citations

DNA damage and cell cycle checkpoints

1996 • 302 citations

Slow Repair of Pyrimidine Dimers at p53 Mutation Hotspots in Skin Cancer

1994 • 301 citations

Endogenous DNA adducts: Potential and paradox

1993 • 284 citations

Specific UV-induced mutation spectrum in the p53 gene of skin tumors from DNA-repair-deficient xeroderma pigmentosum patients.

1993 • 278 citations

Biological basis of germline mutation: Comparisons of spontaneous germline mutation rates among drosophila, mouse, and human

1995 • 272 citations

REV3, a Saccharomyces cerevisiae gene whose function is required for induced mutagenesis, is predicted to encode a nonessential DNA polymerase

1989 • 270 citations

Repair of mitochondrial DNA after various types of DNA damage in Chinese hamster ovary cells

1992 • 269 citations

A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein.

1993 • 263 citations

Complete and tissue-independent methylation of CpG sites in the p53 gene: implications for mutations in human cancers.

1995 • 253 citations

Nearest Neighbor Influences on DNA Polymerase Insertion Fidelity

1989 • 247 citations

Transcription-coupled repair removes both cyclobutane pyrimidine dimers and 6-4 photoproducts with equal efficiency and in a sequential way from transcribed DNA in xeroderma pigmentosum group C fibroblasts.

1995 • 244 citations

Photoproduct frequency is not the major determinant of UV base substitution hot spots or cold spots in human cells.

1987 • 242 citations

DISTRIBUTION AND REPAIR OF PHOTOLESIONS IN DNA: GENETIC CONSEQUENCES AND THE ROLE OF SEQUENCE CONTEXT

1993 • 241 citations

UV MUTAGENIC PHOTOPRODUCTS IN Escherichia coli AND HUMAN CELLS: A MOLECULAR GENETICS PERSPECTIVE ON HUMAN SKIN CANCER*

1988 • 236 citations

WAVELENGTH DEPENDENT FORMATION OF THYMINE DIMERS AND (6‐4)PHOTOPRODUCTS IN DNA BY MONOCHROMATIC ULTRAVIOLET LIGHT RANGING FROM 150 TO 365 nm

1991 • 234 citations

Reactive oxygen and DNA damage in mitochondria

1992 • 234 citations

p53 Mutations Are Common and Early Events that Precede Tumor Invasion in Squamous Cell Neoplasia of the Skin

1993 • 229 citations

DNA damage and rpair with age in individual human lymphocytes

1990 • 214 citations

p53 mutations in basal cell carcinomas.

1992 • 212 citations

Sequence specificity of cyclobutane pyrimidine dimers in DNA treated with solar (ultraviolet B) radiation

1992 • 209 citations

The thymine-thymine pyrimidine-pyrimidone(6-4) ultraviolet light photoproduct is highly mutagenic and specifically induces 3' thymine-to-cytosine transitions in Escherichia coli.

1991 • 208 citations

Development and field-test validation of an assay for DNA repair in circulating human lymphocytes.

1991 • 194 citations

p53 gene mutation: software and database

1996 • 189 citations

Analysis of the p53 gene in human precancerous actinic keratosis lesions and squamous cell cancers

1994 • 186 citations

Use of light for footprinting DNA in vivo

1984 • 181 citations

p53 gene mutations in human epithelial skin cancers.

1993 • 179 citations

In vivo evidence for endogenous DNA alkylation damage as a source of spontaneous mutation in eukaryotic cells.

1993 • 177 citations

Preferential repair of cyclobutane pyrimidine dimers in the transcribed strand of a gene in yeast chromosomes and plasmids is dependent on transcription.

1992 • 176 citations

Comparison of the cleavage of pyrimidine dimers by the bacteriophage T4 and Micrococcus luteus UV-specific endonucleases.

1980 • 175 citations

Repair of oxidative damage within the mitochondrial DNA of RINr 38 cells.

1993 • 175 citations

Cell Cycle-Dependent Strand Bias for UV-Induced Mutations in the Transcribed Strand of Excision Repair-Proficient Human Fibroblasts but Not in Repair-Deficient Cells

1991 • 169 citations

Sequence specificity of point mutations induced during passage of a UV-irradiated shuttle vector plasmid in monkey cells.

1986 • 167 citations

Binding of transcription factors creates hot spots for UV photoproducts in vivo.

1992 • 163 citations

Mitochondrial DNA alterations as ageing-associated molecular events

1992 • 163 citations

Pyrimidine dimer removal enhanced by DNA repair liposomes reduces the incidence of UV skin cancer in mice.

1992 • 155 citations

Use of the alkaline comet assay to detect DNA repair deficiencies in human fibroblasts exposed to UVC, UVB, UVA and gamma-rays

1996 • 154 citations

The distribution of UV photoproducts along the human p53 gene and its relation to mutations in skin cancer.

1993 • 152 citations

Molecular Mechanisms of Radiation Effects

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How much do we know about spontaneous human mutation rates?

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In vivo evidence that UV-induced C .fwdarw. T mutations at dipyrimidine sites could result from the replicative bypass of cis-syn cyclobutane dimers or their deamination products

1993 • 143 citations

Nonrandom induction of pyrimidine-pyrimidone (6-4) photoproducts in ultraviolet-irradiated human chromatin.

1990 • 142 citations

UV light-induced cyclobutane pyrimidine dimers are mutagenic in mammalian cells.

1986 • 142 citations

Tandem double CC-->TT mutations are produced by reactive oxygen species.

1993 • 141 citations

N-nitroso-N-methylurea-induced rat mammary tumors arise from cells with preexisting oncogenic Hras1 gene mutations.

1994 • 141 citations

DNA Repair Rates Mapped Along the Human PGK1 Gene at Nucleotide Resolution

1994 • 135 citations

UV Light as a Footprinting Agent: Modulation of UV-induced DNA Damage by Transcription Factors Bound at the Promoters of Three Human Genes

1995 • 131 citations

In vivo protein-DNA interactions at the c-jun promoter: preformed complexes mediate the UV response.

1993 • 128 citations

p53 Gene Mutations in Human Skin Cancers and Precancerous Lesions: Comparison with Immunohistochemical Analysis

1994 • 125 citations

Mutations in the p53 tumor suppressor gene in human cutaneous squamous cell carcinomas

1991 • 124 citations

Weak male-driven molecular evolution in rodents.

1994 • 123 citations

Mechanism of action of a mammalian DNA repair endonuclease

1986 • 120 citations

Exonucleolytic proofreading by calf thymus DNA polymerase delta.

1987 • 111 citations

Can we predict solar ultraviolet radiation as the causal event in human tumours by analysing the mutation spectra of the p53 gene?

1994 • 107 citations

Cell cycle-dependent strand bias for UV-induced mutations in the transcribed strand of excision repair-proficient human fibroblasts but not in repair-deficient cells.

1991 • 107 citations

The C-C (6-4) UV photoproduct is mutagenic in Escherichia coli.

1986 • 101 citations

Ultraviolet-specific mutations in p53 gene in skin tumors in xeroderma pigmentosum patients.

1993 • 99 citations

Progression of basal cell carcinoma through loss of chromosome 9q and inactivation of a single p53 allele.

1994 • 98 citations

The lacI shuttle: rapid analysis of the mutagenic specificity of ultraviolet light in human cells.

1985 • 98 citations

Repair and Transcription: Collision or collusion?

1994 • 97 citations

Specificity of the yeast rev3 delta antimutator and REV3 dependency of the mutator resulting from a defect (rad1 delta) in nucleotide excision repair.

1994 • 93 citations

Rapid repair kinetics of pyrimidine(6–4)pyrimidone photoproducts in human cells are due to excision rather than conformational change

1990 • 92 citations

Mapping of Copper/Hydrogen Peroxide-induced DNA Damage at Nucleotide Resolution in Human Genomic DNA by Ligation-mediated Polymerase Chain Reaction

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Rate and extent of DNA repair in nondividing human diploid fibroblasts.

1981 • 83 citations

The kinetics of thymine dimer excision in ultraviolet-irradiated human cells

1978 • 81 citations

Mutational spectra in human B-cells

1992 • 81 citations

Photofootprint of nucleosome core DNA in intact chromatin having different structural states

1988 • 78 citations

Mapping of UV photoproducts within ras proto-oncogenes in UV-irradiated cells: correlation with mutations in human skin cancer.

1992 • 72 citations

DNA repair related to multiple skin cancers and drug use.

1994 • 71 citations

Excision repair at individual bases of the Escherichia coli lacI gene: relation to mutation hot spots and transcription coupling activity.

1992 • 71 citations

Aberrations of the Tumor Suppressor p53 Gene and p53 Protein in Solar Keratosis in Human Skin

1994 • 70 citations

Induction and persistence of pyrimidine dimers in the epidermal DNA of two strains of hairless mice.

1977 • 69 citations

Repair of Pyrimidine (6-4)pyrimidone Photoproducts in Mouse Skin

1990 • 67 citations

GC-rich regions in genomes as targets for DNA alkylation

1988 • 66 citations

Activation of the c-Ki-ras oncogene in aflatoxin B1-induced hepatocellular carcinoma and adenoma in the rat: detection by denaturing gradient gel electrophoresis.

1993 • 66 citations

Repair of individual DNA strands in the hamster dihydrofolate reductase gene after treatment with ultraviolet light, alkylating agents, and cisplatin.

1993 • 66 citations

DNA strand bias in the repair of the p53 gene in normal human and xeroderma pigmentosum group C fibroblasts.

1993 • 65 citations

Substrate specificity of a mammalian DNA repair endonuclease that recognizes oxidative base damage.

1986 • 61 citations

Ultraviolet-induced mutations in Cockayne syndrome cells are primarily caused by cyclobutane dimer photoproducts while repair of other photoproducts is normal.

1993 • 61 citations

The T-T pyrimidine (6–4) pyrimidinone UV photoproduct is much less mutagenic in yeast than inEscherichia coli

1995 • 59 citations

Specificities of the Saccharomyces cerevisiae rad6, rad18, and rad52 mutators exhibit different degrees of dependence on the REV3 gene product, a putative nonessential DNA polymerase.

1995 • 58 citations

Agarose Gel Electrophoresis for DNA Damage Analysis

1996 • 57 citations

Increased UV resistance of a xeroderma pigmentosum revertant cell line is correlated with selective repair of the transcribed strand of an expressed gene.

1993 • 57 citations

DNA repair capacity as a risk factor for non‐melanocytic skin cancer—a molecular epidemiological study

1994 • 56 citations

Oxygen radical induced mutagenesis is DNA polymerase specific

1994 • 56 citations

Bypass and termination at apurinic sites during replication of single-stranded DNA in vitro: a model for apurinic site mutagenesis.

1988 • 55 citations

Complete Replication of Plasmid DNA Containing a Single UV-induced Lesion in Human Cell Extracts

1996 • 55 citations

Ultraviolet-induced cyclobutane pyrimidine dimers are selectively removed from transcriptionally active genes in the epidermis of the hairless mouse.

1993 • 50 citations

Induction, repair and accumulation of thymin dimers in the skin of UV-B-irradiated hairless mice

1991 • 49 citations

Thermal resistance to photoreactivation of specific mutations potentiated in E. coli B/r ung by ultraviolet light

1981 • 48 citations

Sequence specificity for removal of uracil from U·A pairs and U·G mismatches by uracil‐DNA glycosylase from Escherichia coli, and correlation with mutational hotspots

1995 • 46 citations

Distribution of 7-alkyl-2'-deoxyguanosine adduct levels in human lung

1996 • 45 citations

Physiological properties and repair of apurinic/apyrimidinic sites and imidazole ring-opened guanines in DNA

1990 • 45 citations

Sequence-based analysis of the human p53 gene based on microdissection of tumor biopsy samples.

1994 • 44 citations

Comparison of the rate of excision of major UV photoproducts in the strands of the human HPRT gene of normal and xeroderma pigmentosum variant cells

1996 • 44 citations

Database and software for the analysis of mutations at the human hprt gene.

1994 • 43 citations

DNA repair endonuclease activity during synchronous growth of diploid human fibroblasts

1990 • 42 citations

Formation and persistence of DNA adducts in different target tissues of rats after multiple administration of benzo[a]pyrene

1996 • 40 citations

CYCLOBUTANE DIMERS AND (6‐4)PHOTOPRODUCTS IN HUMAN CELLS ARE MENDED WITH THE SAME PATCH SIZES

1991 • 39 citations

Enhanced somatic mutation rates induced in stem cells of mice by low chronic exposure to ethylnitrosourea.

1995 • 38 citations

Ligation-Mediated PCR for Analysis of UV Damage

1996 • 37 citations

DNA BREAKS CAUSED BY MONOCHROMATIC 365 nm ULTRAVIOLET‐A RADIATION OR HYDROGEN PEROXIDE and THEIR REPAIR IN HUMAN EPITHELIOID and XERODERMA PIGMENTOSUM CELLS

1991 • 37 citations

DNA repair in the c-myc proto-oncogene locus: possible involvement in susceptibility or resistance to plasmacytoma induction in BALB/c mice.

1991 • 35 citations

SKH-1 hairless mice repair UV-induced pyrimidine dimers in epidermal DNA

1990 • 35 citations

Methyl methanesulfonate adduct formation and repair in the DHFR gene and in mitochondrial DNA in hamster cells

1993 • 34 citations

Intragenic Domains of Strand-specific Repair in

1995 • 34 citations

High Resolution Mapping of UV-induced Photoproducts in the Escherichia coli lacI Gene

1994 • 33 citations

Ultraviolet-Induced Damage and Its Repair in Human DNA

1982 • 33 citations

The distribution of UV damage in the lacI gene of Escherichia coli: Correlation with mutation spectrum

1992 • 30 citations

3-Methyladenine and 7-methylguanine exhibit no preferential removal from the transcribed strand of the dihydrofolate reductase gene in Chinese hamster ovary B11 cells

1995 • 28 citations

Differences in Pyrimidine Dimer Removal between Rat Skin Cells In Vitro and In Vivo

1988 • 28 citations

Thermal resistance of UV-mutagenesis to photoreactivation in E. coli B/r uvrA ung: estimate of activation energy and further analysis

1986 • 27 citations

Strand Specificity of Mutagenic Bypass Replication of DNA Containing Psoralen Monoadducts in a Human Cell Extract

1996 • 25 citations

DNA repair and cytokines in antimutagenesis and anticarcinogenesis

1996 • 24 citations

DNA adducts in model systems and humans

1993 • 24 citations

Genomic Footprinting by Ligation Mediated Polymerase Chain Reaction

2003 • 23 citations

In situ (6-4)photoproduct determination by laser cytometry and autoradiography

1990 • 23 citations

Formation and persistence of DNA adducts in pouch skin fibroblasts and liver tissue of rats exposed in vivo to the monofunctional alkylating agents N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea

1994 • 23 citations

Ligation-Mediated PCR for Analysis of Oxidative DNA Damage

1996 • 21 citations

Lesion selectivity in blockage of lambda exonuclease by DNA damage

1990 • 21 citations

Capacity of individual chronic lymphatic leukemia lymphocytes and leukemic blast cells for repair of O6-ethylguanine in DNA: relation to chemosensitivity in vitro and treatment outcome.

1994 • 21 citations

The removal of UV-induced pyrimidine dimers from DNA of rat skin cells in vitro and in vivo in relation to aging

1989 • 19 citations

Recovery from ultraviolet‐induced growth arrest of primary rat hepatocytes by p53 antisense oligonucleotide treatment

1994 • 18 citations

DNA Adduct Measurements and Tumor Incidence during Chronic Carcinogen Exposure in Rodents

1994 • 17 citations

Analysis of Chemically Induced Mutation in Single Cell Populations

1983 • 17 citations

Excision repair influences the site and strand specificity of sunlight mutagenesis in yeast

1992 • 15 citations

Site-Specific Excision Repair of 1-Nitrosopyrene-Induced DNA Adducts at the Nucleotide Level in the HPRT Gene of Human Fibroblasts: Effect of Adduct Conformation on the Pattern of Site-Specific Repair

1996 • 11 citations

INDUCTION and DISAPPEARANCE OF THYMINE DIMERS IN HUMAN SKIN EXPOSED TO UVB RADIATION: FLOW CYTOMETRIC MEASUREMENTS IN REPLICATING and NONREPLICATING EPIDERMAL CELLS

1995 • 10 citations

Relationship between DNA-adduct formation, DNA repair, mutation frequency and mutation spectra.

1989 • 6 citations

Inducible Repair in Mammalian Cells Treated with Alkylating Agents

1989 • 3 citations

Influence of DNA Repair Capacity and Cell Differentiation on UV-induced Gene Expression

1994 • 2 citations