A temperature-sensitive mutant of human p53.

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Definition of a consensus binding site for p53

1992 • 2,000 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

The E2F transcription factor is a cellular target for the RB protein

1991 • 1,461 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

mdm2 expression is induced by wild type p53 activity.

1993 • 1,286 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

Identification of p53 as a Sequence-Specific DNA-Binding Protein

1991 • 1,109 citations

Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form.

1990 • 978 citations

Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis.

1989 • 961 citations

Oncogenic forms of p53 inhibit p53-regulated gene expression

1992 • 933 citations

Regulation of the specific DNA binding function of p53

1992 • 914 citations

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

1993 • 875 citations

Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo

1991 • 874 citations

Presence of a Potent Transcription Activating Sequence in the p53 Protein

1990 • 811 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

Wild-type p53 can inhibit oncogene-mediated focus formation.

1989 • 738 citations

A transcriptionally active DNA-binding site for human p53 protein complexes.

1992 • 729 citations

Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis.

1993 • 677 citations

Transcriptional Activation by Wild-Type but Not Transforming Mutants of the p53 Anti-Oncogene

1990 • 644 citations

Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation

1991 • 617 citations

Wild-type p53 activates transcription in vitro

1992 • 609 citations

Mechanisms of Tumor Progression

2010 • 608 citations

Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines.

1990 • 607 citations

Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein.

1991 • 544 citations

An immunochemical analysis of the human nuclear phosphoprotein p53

1992 • 533 citations

Wild-type p53 binds to the TATA-binding protein and represses transcription.

1992 • 527 citations

Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53.

1990 • 502 citations

P53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features

1992 • 448 citations

Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53

1993 • 329 citations

Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element.

1992 • 328 citations

Regulation of the Human hsp70 Promoter by p53

1993 • 297 citations

Monoclonal antibody analysis of p53 expression in normal and transformed cells

1986 • 285 citations

Spontaneous abnormalities in normal fibroblasts from patients with Li-Fraumeni cancer syndrome: aneuploidy and immortalization.

1990 • 256 citations

The p53 Activation Domain Binds the TATA Box-Binding Polypeptide in Holo-TFIID, and a Neighboring p53 Domain Inhibits Transcription

1993 • 246 citations

A Transcriptionally Active DNA-Binding Site for Human p53 Protein Complexes

1992 • 234 citations

The murine p53 protein blocks replication of SV40 DNA in vitro by inhibiting the initiation functions of SV40 large T antigen

1989 • 216 citations

Mutant conformation of p53

1992 • 214 citations

Mammalian p53 can function as a transcription factor in yeast

1992 • 182 citations

Protein synthesis required to anchor a mutant p53 protein which is temperature-sensitive for nuclear transport

1991 • 180 citations

The MCK enhancer contains a p53 responsive element.

1991 • 170 citations

Evidence that p53 behaves as a tumour suppressor gene in sporadic breast tumours.

1990 • 165 citations

Sequence-specific DNA binding by p53: identification of target sites and lack of binding to p53 - MDM2 complexes.

1993 • 152 citations

Induction of growth arrest by a temperature-sensitive p53 mutant is correlated with increased nuclear localization and decreased stability of the protein.

1991 • 142 citations

Negative regulation of Rb expression by the p53 gene product.

1992 • 136 citations

A potential transcriptional activation element in the p53 protein.

1990 • 129 citations

Different forms of p53 detected by monoclonal antibodies in non-dividing and dividing lymphocytes

1984 • 126 citations

Expression of wild-type p53 is not compatible with continued growth of p53-negative tumor cells.

1991 • 117 citations

Heterogeneity of transcriptional activity of mutant p53 proteins and p53 DNA target sequences.

1993 • 110 citations

Addition of fresh medium induces cell cycle and conformation changes in p53, a tumour suppressor protein.

1990 • 95 citations

Increased expression of p53 protein in human leukemia cells.

1986 • 94 citations

Lack of nuclear RB protein staining in G0/middle G1 cells: correlation to changes in total RB protein level.

1991 • 88 citations

Regulation of p53 protein expression in human breast cancer cell lines

1993 • 85 citations

Altered conformation of the p53 protein in myeloid leukemia cells and mitogen-stimulated normal blood cells.

1992 • 83 citations

A functional screen for germ line p53 mutations based on transcriptional activation.

1992 • 66 citations

Novel DNA binding of p53 mutants and their role in transcriptional activation.

1993 • 65 citations

Nuclear binding of purified retinoblastoma gene product is determined by cell cycle-regulated phosphorylation.

1992 • 64 citations

Mouse p53 blocks SV40 DNA replication in vitro and downregulates T antigen DNA helicase activity.

1988 • 63 citations

Mammalian p53 can function as a transcription factor in yeast

1992 • 36 citations

Induction of Growth Arrest by a Temperature-Sensitive p53 Mutant Is Correlated with Increased Nuclear Localization and Decreased Stability of the Protein

1991 • 35 citations

Polymorphism at codon 72 of the p53 gene in human acute myelogenous leukemia

1992 • 33 citations

Inactive p53 mutants may enhance the transcriptional activity of wild-type p53.

1993 • 30 citations

Expression of Wild-Type p53 Is Not Compatible with - Continued Growth of p53-Negative Tumor Cells

1991 • 27 citations