Retrovirus–mediated wild–type P53 gene transfer to tumors of patients with lung cancer.

p53 Mutations in Human Cancers

1991 • 8,133 citations

Mutation and Cancer: Statistical Study of Retinoblastoma

1971 • 7,335 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

Improved retroviral vectors for gene transfer and expression.

1989 • 1,997 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

Tumor Suppressor Genes

1991 • 1,784 citations

Molecular themes in oncogenesis

1991 • 1,663 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

A Randomized Trial of Induction Chemotherapy plus High-Dose Radiation versus Radiation Alone in Stage III Non-Small-Cell Lung Cancer

1990 • 1,163 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

1993 • 875 citations

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

1992 • 871 citations

p53 functions as a cell cycle control protein in osteosarcomas.

1990 • 774 citations

Wild-Type Human p53 and a Temperature-Sensitive Mutant Induce Fas/APO-1 Expression

1995 • 736 citations

Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene.

1994 • 465 citations

Mutations of p53 and ras genes in radon-associated lung cancer from uranium miners

1992 • 315 citations

p53 gene mutations in Barrett's epithelium and esophageal cancer.

1991 • 266 citations

High-efficiency gene transfer and high-level expression of wild-type p53 in human lung cancer cells mediated by recombinant adenovirus.

1994 • 257 citations

p53 and chromosome 3 abnormalities, characteristic of malignant lung tumours, are detectable in preinvasive lesions of the bronchus

1993 • 256 citations

Growth suppression of human head and neck cancer cells by the introduction of a wild-type p53 gene via a recombinant adenovirus.

1994 • 247 citations

Discordant p53 gene mutations in primary head and neck cancers and corresponding second primary cancers of the upper aerodigestive tract.

1993 • 241 citations

Progression of colorectal cancer is associated with multiple tumor suppressor gene defects but inhibition of tumorigenicity is accomplished by correction of any single defect via chromosome transfer.

1992 • 237 citations

Comprehensive Criteria for Assessing Therapy-Induced Toxicity

1990 • 234 citations

Therapeutic Effect of a Retroviral Wild-Type p53 Expression Vector in an Orthotopic Lung Cancer Model

1994 • 214 citations

Allele-Specific Loss in Chromosome 9p Loci in Preneoplastic Lesions Accompanying Non-Small-Cell Lung Cancers

1995 • 211 citations

Wild-type but not mutant p53 suppresses the growth of human lung cancer cells bearing multiple genetic lesions.

1992 • 200 citations

A retroviral wild-type p53 expression vector penetrates human lung cancer spheroids and inhibits growth by inducing apoptosis

1994 • 195 citations

Specific inhibition of K-ras expression and tumorigenicity of lung cancer cells by antisense RNA

1991 • 188 citations

Protamine sulfate as an effective alternative to polybrene in retroviral-mediated gene-transfer: implications for human gene therapy

1989 • 149 citations

Stable Expression of the Wild-Typep53Gene in Human Lung Cancer Cells after Retrovirus-Mediated Gene Transfer

1993 • 121 citations

Retroviral Vector-Mediated Transduction of K-rasAntisense RNA into Human Lung Cancer Cells Inhibits Expression of the Malignant Phenotype

1993 • 115 citations

Mutations of p53 in barrett's esophagus and barrett's cancer: A prospective study of ninety-eight cases

1996 • 109 citations

Proliferative potential and p53 overexpression in precursor and early stage lesions of bronchioloalveolar lung carcinoma.

1995 • 96 citations

Apoptosis induced in human osteosarcoma cells is one of the mechanisms for the cytocidal effect of Ad5CMV-p53.

1995 • 58 citations

In Vitro Assessment of Variables Affecting the Efficiency and Efficacy of Adenovirus-Mediated Gene Transfer to Cystic Fibrosis Airway Epithelia

1996 • 38 citations

Transgene inheritance and retroviral infection contribute to the efficiency of gene expression in solid tumors inoculated with retroviral vector producer cells.

1995 • 32 citations

Incorporation of 5-bromo-2'-deoxyuridine into colorectal liver metastases and liver in patients receiving a 7-day hepatic arterial infusion.

1995 • 25 citations

Modification of Tumor Suppressor Gene Expression in Non-Small Cell Lung Cancer (NSCLC) with a Retroviral Vector Expressing Wildtype (normal) p53. University of Texas M.D. Anderson Cancer Center, Houston, Texas

1996 • 21 citations

Minutes for September 14–15, 1992 Recombinant DNA Advisory Committee

1993 • 4 citations