An Adenovirus Mutant That Replicates Selectively in p53- Deficient Human Tumor Cells

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

1983 • 1,358 citations

The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines.

1991 • 857 citations

p53 functions as a cell cycle control protein in osteosarcomas.

1990 • 774 citations

Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein

1992 • 567 citations

Partial transformation of primary rat cells by the leftmost 4.5% fragment of adenovirus 5 DNA

1980 • 463 citations

Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection

1987 • 394 citations

Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage.

1993 • 334 citations

Analysis of the p53 gene and its expression in human glioblastoma cells.

1994 • 329 citations

Blockage by Adenovirus E4orf6 of Transcriptional Activation by the p53 Tumor Suppressor

1996 • 315 citations

A comparative study of p53 gene mutations, protein accumulation, and response to cisplatin-based chemotherapy in advanced ovarian carcinoma.

1996 • 277 citations

p53 point mutation in HPV negative human cervical carcinoma cell lines.

1991 • 271 citations

Domains required for in vitro association between the cellular p53 and the adenovirus 2 E1B 55k proteins

1990 • 207 citations

Microbial growth on C1 compounds. 6. Oxidation of methanol, formaldehyde and formate by methanol-grown Pseudomonas AM 1

1964 • 181 citations

Human pancreatic carcinomas and cell lines reveal frequent and multiple alterations in the p53 and Rb-1 tumor-suppressor genes.

1992 • 171 citations

Transformation with specific fragments of adenovirus DNAs I. Isolation of specific fragments with transforming activity of adenovirus 2 and 5 DNA

1977 • 170 citations

Adenovirus E1A targets key regulators of cell proliferation.

1992 • 148 citations

Mutation detection by highly sensitive methods indicates that p53 gene mutations in breast cancer can have important prognostic value.

1996 • 135 citations

Interaction of adenoviral proteins with pRB and p53

1993 • 134 citations

Apoptosis II: The Molecular Basis of Apoptosis in Disease

1994 • 126 citations

Apoptosis II The molecular basis of apoptosis in disease

1995 • 92 citations

Expression and interactions of human adenovirus oncoproteins

1991 • 88 citations

Astronomers Tame a Workhorse Laser

1996 • 55 citations

Analysis of viral-host protein interactions and tumorigenesis in transgenic mice.

1994 • 32 citations

Heavy isotope record

1994 • 1 citations