5-Methylcytosine in Eukaryotic DNA

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

A new method for sequencing DNA.

1977 • 7,941 citations

DNA Methylation and Gene Function

1980 • 2,069 citations

Molecular structure of a left-handed double helical DNA fragment at atomic resolution

1979 • 2,057 citations

Cellular differentiation, cytidine analogs and DNA methylation

1980 • 1,803 citations

Cloning and characterization of ribosomal RNA genes from wheat and barley

1979 • 1,499 citations

Changes in size and secondary structure of the ribosomal transcription unit during vertebrate evolution

1975 • 1,188 citations

Molecular basis of base substitution hotspots in Escherichia coli

1978 • 1,185 citations

DNA methylation and the frequency of CpG in animal DNA

1980 • 1,146 citations

Sequence-specific recognition of double helical nucleic acids by proteins.

1976 • 1,123 citations

Effects of methylation on a synthetic polynucleotide: the B--Z transition in poly(dG-m5dC).poly(dG-m5dC).

1981 • 873 citations

Mutagenic deamination of cytosine residues in DNA

1980 • 761 citations

DNA methylation in the human γδβ-globin locus in erythroid and nonerythroid tissues

1980 • 634 citations

DNA Glycosylases, Endonucleases for Apurinic/Apyrimidinic Sites, and Base Excision-Repair

1979 • 562 citations

Left-handed DNA helices

1980 • 519 citations

Use of restriction enzymes to study eukaryotic DNA methylation

1978 • 442 citations

Globin mRNA Sequences: Analysis of Base Pairing and Evolutionary Implications

1978 • 403 citations

MspI, an isoschizomer of HpaII which cleaves both unmethylated and methylated HpaII sites

1978 • 395 citations

Escherichia coli mutator mutants deficient in methylation-instructed DNA mismatch correction.

1980 • 391 citations

Rare Bases in Animal DNA

1970 • 375 citations

Isolation of Deoxyribonucleic Acid Methylase Mutants of Escherichia coli K-12

1973 • 372 citations

The somatic replication of DNA methylation

1981 • 368 citations

Specific DNA methylation sites in the vicinity of the chicken β-globin genes

1979 • 365 citations

DNA methylation: organ specific variations in the methylation pattern within and around ovalbumin and other chicken genes

1979 • 356 citations

Interaction of HMG 14 and 17 with actively transcribed genes

1980 • 355 citations

Quantitative reversed-phase high performance liquid chromatographic determination of major and modified deoxyribonucleosides in DNA

1980 • 328 citations

Use of restriction enzymes to study eukaryotic DNA methylation

1978 • 281 citations

Genetic Recombination: Strand Transfer and Mismatch Repair

1978 • 270 citations

Composition and structure of chromosomal and amplified ribosomal DNA's of Xenopus laevis

1970 • 269 citations

DNA methylation at a CCGG sequence in the large intron of the rabbit β-globin gene: tissue-specific variations

1978 • 268 citations

Comparison of bisulfite modification of 5-methyldeoxycytidine and deoxycytidine residues

1980 • 243 citations

Altering Genotype and Phenotype by DNA-Mediated Gene Transfer

1980 • 242 citations

Sequence organization of the spacer DNA in a ribosomal gene unit of Xenopus laevis

1979 • 226 citations

Selective Silencing of Eukaryotic DNA

1975 • 224 citations

Modified Bases in Bacteriophage DNAs

1980 • 216 citations

Methylation of DNA in developing sea urchin embryos

1968 • 214 citations

Variable patterns of total DNA and rDNA methylation in animals

1980 • 210 citations

A new theory of carcinogenesis

1979 • 201 citations

Nucleotide Sequence Specificity of Restriction Endonucleases

1979 • 199 citations

Methylated and unmethylated DNA compartments in the sea urchin genome

1979 • 195 citations

Distribution of 5-methylcytosine in pyrimidine sequences of deoxyribonucleic acids

1962 • 193 citations

Direct detection of methylated cytosine in DNA by use of the restriction enzyme Mspl

1979 • 188 citations

5-Methylcytosine content of nuclear DNA during chemical hepatocarcinogenesis and in carcinomas which result

1979 • 182 citations

Methylation of Herpesvirus saimiri DNA in lymphoid tumor cell lines

1979 • 179 citations

The nucleotide sequence of oocyte 5S DNA in Xenopus laevis. II. The GC-rich region

1978 • 178 citations

Comparative study of DNA methylation in three unicellular eucaryotes

1978 • 176 citations

Tissue-specific DNA methylation in a cluster of rabbit beta-like globin genes.

1980 • 172 citations

Doublet frequency analysis of fractionated vertebrate nuclear DNA

1976 • 172 citations

Solvent-accessible surfaces of nucleic acids

1979 • 165 citations

THE ACTION OF PANCREATIC DESOXYRIBONUCLEASE

1954 • 161 citations

Methylation of milk-borne and genetically transmitted mouse mammary tumor virus proviral DNA

1980 • 155 citations

DNA methylation in adenovirus, adenovirus-transformed cells, and host cells.

1976 • 155 citations

Hypomethylation of DNA during differentiation of friend erythroleukemia cells

1980 • 154 citations

The content of 5-methylcytosine in animal DNA: The species and tissue specificity

1973 • 153 citations

Detection of 5-methylcytosine in DNA sequences

1978 • 148 citations

Methylation of Mouse Liver DNA Studied by Means of the Restriction Enzymes Msp I and Hpa II

1979 • 146 citations

Isolation of actively transcribed nucleosomes using immobilized HMG 14 and 17 and an analysis of α-globin chromatin

1981 • 143 citations

Differential methylation of mitochondrial and nuclear DNA in cultured mouse, hamster and virus-transformed hamster cells In vivo and in vitro methylation

1973 • 138 citations

Methylated bases in DNA from Paramecium aurelia

1974 • 137 citations

DNA methylation and viral gene expression in adenovirus-transformed and-infected cells

1980 • 131 citations

Properties of the satellite DNA associated with the chloroplasts of Euglena gracilis

1964 • 131 citations

DNA methylation: correlation with DNase I sensitivity of chicken ovalbumin and conalbumin chromatin

1979 • 130 citations

THE ACTION OF PANCREATIC DEOXYRIBONUCLEASE

1955 • 129 citations

DNA methylase from HeLa cell nuclei

1975 • 114 citations

The kinetics of DNA methylation in cultures of a mouse adrenal cell line

1970 • 112 citations

Genomic rearrangements in a mouse cell line containing integrated SV40 DNA

1981 • 108 citations

Modified bases in the DNAs of unicellular eukaryotes: an examination of distributions and possible roles, with emphasis on hydroxymethyluracil in dinoflagellates

1978 • 108 citations

Mouse nuclear satellite DNA: 5-methylcytosine content, pyrimidine isoplith distribution and electron microscopic appearance

1969 • 105 citations

Role of methylation in the modification and restriction of chloroplast DNA in Chlamydomonas.

1979 • 102 citations

Chloroplast DNA from Tobacco Leaves

1966 • 101 citations

DNA-methylase from regenerating rat liver: purification and characterisation

1978 • 99 citations

Replicational Fidelity: Mechanisms of Mutation Avoidance and Mutation Fixation

1979 • 96 citations

Organization of 5-methylcytosine in chromosomal DNA

1978 • 95 citations

Unusual properties of the DNA from Xanthomonas phage XP-12 in which 5-methylcytosine completely replaces cytosine

1975 • 93 citations

Nucleotide sequence of a highly repetitive component of rat DNA

1979 • 91 citations

Mouse DNA methylase: Methylation of native DNA

1979 • 86 citations

Sequence arrangement of a highly methylated satellite DNA of a plant, Scilla : A tandemly repeated inverted repeat

1981 • 85 citations

Studies on gene control regions XII. The functional significance of a Lac operator constitutive mutation

1979 • 84 citations

5-Methylcytidylic Acid: Absence from Mitochondrial DNA of Frogs and HeLa Cells

1974 • 84 citations

Methylation of mosquito DNA

1979 • 84 citations

The 5′-cytosine in CCGG¹is methylated in two eukaryotic DNAS and Msp I is sensitive to methylatlon at this site

1980 • 74 citations

S-adenosylmethionine: DNA-cytosine 5-methyltransferase from a Novikoff rat hepatoma cell line

1975 • 73 citations

5-Methylcytosine content of rat hepatoma DNA substituted with bromodeoxyuridine.

1977 • 73 citations

Promotion and Limitation of Genetic Exchange

1979 • 72 citations

Mitochondrial DNA from various organisms does not contain internally methylated cytosine in -CCGG- sequences

1979 • 71 citations

A Relationship Between DNA Helix Stability and Recognition Sites for RNA Polymerase

1979 • 64 citations

Methylation of somatic vs germ cell DNAs analyzed by restriction endonuclease digestions

1979 • 63 citations

[28] Preparation of apurinic acid and of oligodeoxyribonucleotides with formic acid and diphenylamine

1967 • 61 citations

The 5‐methylcytosine content of DNA: Tissue specificity

1971 • 59 citations

Molecular Cloning, Refined Physical Map and Heterogeneity of Methylation Sites of Papilloma Virus Type 1a DNA

1980 • 59 citations

Localization of 5-methylcytosine in human metaphase chromosomes by immunoelectron microscopy

1976 • 58 citations

Modification of avian sarcoma proviral DNA sequences in nonpermissive XC cells but not in permissive chicken cells

1980 • 57 citations

Methylation of chloroplast DNAs in the life cycle of Chlamydomonas

1979 • 55 citations

12 Deoxyribonuclease I

1971 • 51 citations

Single-strand and double-strand cleavage at half-modified and fully modified recognition sites for the restriction nucleases Sau3A and TaqI

1980 • 48 citations

Methylation of mouse DNA in vivo

1970 • 47 citations

Methylation of the Deoxyribonucleic Acid of Physarum polycephalum at Various Periods during the Mitotic Cycle

1970 • 47 citations

Identification of 5-methylcytosine in DNA fragments immobilized on nitrocellulose paper.

1980 • 47 citations

The sequence specificity of vertebrate DNA methylation

1977 • 44 citations

Deoxyribonucleic Acid Methyltransferase from the Eukaryote, Chlamydomonas reinhardi

1980 • 43 citations

Methylation of parental and progeny DNA strands in Physarum polycephalum

1973 • 42 citations

Methylation of DNA in early development: 5-methyl cytosine content of DNA in sea urchin sperm and embryos

1978 • 42 citations

Fractionation and characterization of satellite DNAs of the kangaroo rat (Dipodomys ordii)

1974 • 41 citations

Reaction of hydroxylamine at high concentration with deoxycytidine or with polycytidylic acid: Evidence that substitution of amino groups in cytosine residues by hydroxylamino is a primary reaction, and the possible relevance to hydroxylamine mutagenesis

1967 • 38 citations

5-Methylcytosine in the DNA of the polytene chromosomes of the dipteraSciara coprophila,Drosophila melanogaster andD. persimilis

1980 • 38 citations

Ordered distribution of modified bases in the DNA of a dinoflagellate

1980 • 36 citations

Content and localisation of 5-methylcytosine in DNA of healthy and wilt-infected cotton plants

1975 • 35 citations

DNA methylationin normal and tumour virus-transformed cells in tissue culture I. The level of DNA methylation in BHK21 cells and in BHK21 cells transformed by polyoma virus (PyY cells)

1973 • 34 citations

Separation of Six DNA Bases by Ion Pair--Reversed Phase High Pressure Liquid Chromatography

1979 • 33 citations

Methylation of rapidly reannealing DNA during the cell cycle of chinese hamster cells

1973 • 31 citations

Analysis of 5-methylcytosine in DNA

1976 • 31 citations

5-Methylcytosine in heterochromatic regions of chromosomes in Bovidae

1976 • 31 citations

Methylation of Mammalian Deoxyribonucleic Acid

1972 • 30 citations

Binding of anti-nucleoside antibodies reveals different classes of DNA in the chromosomes of the kangaroo rat (Dipodomys ordii)

1977 • 30 citations

DNA of herpes simplex virus is not a substrate for methylation in vivo

1969 • 30 citations

Enzymatic analysis of 5-methylcytosine content in eukaryotic DNA. Study of intracellular Simian Virus 40 DNA.

1980 • 28 citations

Two sequence-specific endonucleases from Xanthomonas oryzae. Characterization and unusual properties

1980 • 25 citations

Distribution pattern and enzymic hypermethylation of inverted repetitive DNA sequences in P815 mastocytoma cells

1979 • 24 citations

Methylation of Lilium DNA during the meiotic cycle

1971 • 23 citations

Sequence organisation in nuclear DNA from Physarum polycephalum: methylation of repetitive sequences

1981 • 22 citations

Methylation in Physarum DNA

1980 • 19 citations

Characterization of Deoxycytidylate Methyltransferase in Xanthomonas oryzae Infected with Bacteriophage Xp12

1978 • 19 citations

Enzymatic methylation of replication-DNA intermediates in Ehrlich ascites tumor

1975 • 18 citations

5-Methylcytosine in Chlorella pyrenoidosa DNAs

1976 • 11 citations

Nucleic acids methylation of synchronized BHK 21 HS 5 fibroblasts during the mitotic phase

1980 • 10 citations

The structure of animal mitochondrial DNA (base composition, pyrimidine clusters, character of methylation)

1977 • 8 citations

Enzymatic hypermethylation of DNA in mouse-mouse somatic cell hybrids

1980 • 8 citations