Mutations in the p53 gene occur in diverse human tumour types

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase

1988 • 4,259 citations

T antigen is bound to a host protein in SY40-transformed cells

1979 • 2,378 citations

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

1989 • 2,081 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1979 • 1,830 citations

λ ZAP: a bacteriophage λ expression vector within vivoexcision properties

1988 • 1,394 citations

Hereditary cancer, oncogenes, and antioncogenes.

1985 • 1,261 citations

Functional inactivation of genes by dominant negative mutations

1987 • 1,174 citations

Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life.

1988 • 1,140 citations

Rearrangement of the p53 gene in human osteogenic sarcomas.

1987 • 489 citations

Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cells.

1985 • 414 citations

Allelic Loss in Colorectal Carcinoma

1989 • 338 citations

A variation in the structure of the protein-coding region of the human p53 gene

1988 • 286 citations

Meth A fibrosarcoma cells express two transforming mutant p53 species.

1988 • 247 citations

Cloning and characterization of a cDNA from Xenopus laevis coding for a protein homologous to human and murine p53.

1987 • 158 citations

Oligomerization of oncoprotein p53

1988 • 158 citations

Genetic Changes in Human Adrenocortical Carcinomas

1989 • 128 citations

Efficient construction of cDNA libraries in plasmid expression vectors using an adaptor strategy

1986 • 102 citations

Isolation and mapping of a polymorphic DNA sequence (pYNZ22) on chromosome 17p [D17S30]

1988 • 93 citations

Loss of a highly conserved domain on p53 as a result of gene deletion during Friend virus-induced erythroleukemia.

1988 • 75 citations

Characterization of mutant p53-hsp72/73 protein-protein complexes by transient expression in monkey COS cells.

1988 • 72 citations

A hypervariable RFLP on chromosome 17pl3 is defined by an arbitrary single copy probe pl44-D6 [HGM9 No. D17S34]

1987 • 58 citations

The von Recklinghausen neurofibromatosis region on chromosome 17--genetic and physical maps come into focus.

1989 • 47 citations

Chromosome 17p loss in carcinoma of the cervix uteri

1989 • 35 citations