REVIEW ARTICLE. p53: GUARDIAN OF CELLULAR SENESCENCE

The limited in vitro lifetime of human diploid cell strains

1965 • 5,595 citations

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

1994 • 3,536 citations

Telomere length predicts replicative capacity of human fibroblasts.

1992 • 2,209 citations

The multistep nature of cancer

1993 • 1,872 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

Sunburn and p53 in the onset of skin cancer

1994 • 1,501 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

A role for both RB and p53 in the regulation of human cellular senescence*1

1991 • 737 citations

Clonal expansion of p53 mutant cells is associated with brain tumour progression

1992 • 687 citations

Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues.

1995 • 593 citations

Tumour suppressors, kinases and clamps: How p53 regulates the cell cycle in response to DNA damage

1995 • 291 citations

Cell-cycle regulators and cancer

1995 • 291 citations

Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1

1991 • 257 citations

Model for the genetic evolution of human solid tumors.

1989 • 251 citations

Alterations in p53 and p16^INK4 Expression and Telomere Length during Spontaneous Immortalization of Li-Fraumeni Syndrome Fibroblasts

1995 • 248 citations

Escape from senescence in human diploid fibroblasts induced directly by mutant p53.

1994 • 177 citations

The spectrum of molecular alterations in the evolution of chronic myelocytic leukemia.

1991 • 171 citations

Specific chromosome aberrations in senescent fibroblast cell lines derived from human embryos.

1976 • 166 citations

Spontaneous In Vitro Immortalization of Breast Epithelial Cells from a Patient with Li-Fraumeni Syndrome

1995 • 152 citations

Evidence that transcriptional activation by p53 plays a direct role in the induction of cellular senescence.

1996 • 151 citations

Long-term genome stability and minimal genotypic and phenotypic alterations in HPV16 E7-, but not E6-, immortalized human uroepithelial cells.

1994 • 130 citations

Time, telomeres and tumours: is cellular senescence more than an anticancer mechanism?

1995 • 121 citations

TELOMERES AND TELOMERASE IN HUMAN CANCER (REVIEW)

1995 • 106 citations

Cellular immortality: A late event in the progression of human squamous cell carcinoma of the head and neck associated with p53 alteration and a high frequency of allele loss

1995 • 102 citations

p53 deficiency does not affect the accumulation of point mutations in a transgene target.

1995 • 83 citations

Genetic analysis of cellular senescence

1995 • 80 citations

Mutant p53 rescues human diploid cells from senescence without inhibiting the induction of SDI1/WAF1.

1995 • 77 citations

p53 wild-type and p53 nullizygous Big Blue transgenic mice have similar frequencies and patterns of observed mutation in liver, spleen and brain.

1995 • 65 citations

The dominating effect of mutant p53

1995 • 48 citations

Does telomere shortening drive selection for p53 mutation in human cancer?

1995 • 44 citations

Molecular genetics of thyroid cancer

1993 • 37 citations

Direct growth stimulation of normal human epithelial cells by mutant p53

1993 • 29 citations

The role of p53 in tumor progression.

1994 • 28 citations

The Tumour Suppressor Gene p53 as a Regulator of Proliferative Life-Span and Tumour Progression

1996 • 18 citations