A polymorphism but no mutations in the GADD45 gene in breast cancers

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

1994 • 3,536 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

1994 • 2,025 citations

Definition of a consensus binding site for p53

1992 • 2,000 citations

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1993 • 1,445 citations

Clinical Implications of the p53 Tumor-Suppressor Gene

1993 • 1,341 citations

Incidence of Cancer in 161 Families Affected by Ataxia–Telangiectasia

1991 • 944 citations

Interaction of the p53-Regulated Protein Gadd45 with Proliferating Cell Nuclear Antigen

1994 • 941 citations

Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents.

1993 • 770 citations

Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents.

1989 • 698 citations

Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations.

1993 • 565 citations

Induction of cellular p53 activity by DNA-damaging agents and growth arrest.

1993 • 440 citations

Absence of WAF1 mutations in a variety of human malignancies

1994 • 390 citations

Multifactorial analysis of p53 alteration in human cancer: A review

1994 • 359 citations

Genomic Amplification with Transcript Sequencing

1988 • 324 citations

Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway.

1994 • 275 citations

Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C.

1991 • 268 citations

The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasia.

1994 • 253 citations

Ataxia-Telangiectasia

1991 • 238 citations

Analysis of the mammalian gadd45 gene and its response to DNA damage.

1993 • 231 citations

The p53-dependent gamma-ray response of GADD45.

1994 • 225 citations

Ataxia-telangiectasia: an interdisciplinary approach to pathogenesis.

1991 • 225 citations

Domains required for in vitro association between the cellular p53 and the adenovirus 2 E1B 55k proteins

1990 • 207 citations

Increases in sequence specific DNA binding by p53 following treatment with chemotherapeutic and DNA damaging agents.

1993 • 201 citations

Altered Patterns of MDM2 and TP53 Expression in Human Bladder Cancer

1994 • 192 citations

Genotoxic‐Stress‐Response Genes and Growth‐Arrest Genes

1992 • 183 citations

Identification of the p53 protein domain involved in formation of the simian virus 40 large T-antigen-p53 protein complex

1986 • 175 citations

p53 gene mutations inside and outside of exons 5-8: the patterns differ in breast and other cancers.

1995 • 108 citations

Oncogene Amplification in Urothelial Cancers With p53 Gene Mutation or MDM2 Amplification

1994 • 97 citations

Pattern of p53 Gene Mutations in Breast Cancers of Women of the Midwestern United States

1992 • 94 citations

REPORTS

1991 • 92 citations

Polymorphisms and probable lack of mutation in the WAF1-CIP1 gene in colorectal cancer.

1995 • 89 citations

Genetic changes in epithelial solid neoplasia.

1994 • 84 citations

DNA damage increases the levels of MDM2 messenger RNA in wtp53 human cells.

1994 • 74 citations

p53 gene mutations in breast cancers in midwestern US women: null as well as missense-type mutations are associated with poor prognosis.

1994 • 67 citations

Phage Promoter-Based Methods for Sequencing and Screening for Mutations

1994 • 10 citations