The p53 activation domain binds the TATA box-binding polypeptide in Holo-TFIID, and a neighboring p53 domain inhibits transcription.

[6] Use of T7 RNA polymerase to direct expression of cloned genes

1990 • 6,681 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

1989 • 3,219 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

1982 • 3,106 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

How eukaryotic transcriptional activators work

1988 • 1,924 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

GAL4-VP16 is an unusually potent transcriptional activator

1988 • 1,379 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

SRα Promoter: an Efficient and Versatile Mammalian cDNA Expression System Composed of the Simian Virus 40 Early Promoter and the R-U5 Segment of Human T-Cell Leukemia Virus Type 1 Long Terminal Repeat

1988 • 1,351 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

Monoclonal antibodies specific for simian virus 40 tumor antigens

1981 • 1,110 citations

Five intermediate complexes in transcription initiation by RNA polymerase II

1989 • 1,033 citations

p53: oncogene or anti-oncogene?

1990 • 812 citations

Presence of a Potent Transcription Activating Sequence in the p53 Protein

1990 • 811 citations

Wild-type p53 can inhibit oncogene-mediated focus formation.

1989 • 738 citations

Isolation of coactivators associated with the TATA-binding protein that mediate transcriptional activation

1991 • 711 citations

Direct and selective binding of an acidic transcriptional activation domain to the TATA-box factor TFIID

1990 • 620 citations

Activators and targets

1990 • 582 citations

Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein

1992 • 567 citations

Mechanism of action of an acidic transcriptional activator in vitro

1991 • 557 citations

Wild-type p53 binds to the TATA-binding protein and represses transcription.

1992 • 527 citations

NF-κB and related proteins: Rel/dorsal homologies meet ankyrin-like repeats

1992 • 415 citations

Crystal structure of TFIID TATA-box binding protein

1992 • 410 citations

Coactivators for a proline-rich activator purified from the multisubunit human TFIID complex.

1991 • 381 citations

Binding of general transcription factor TFIIB to an acidic activating region

1991 • 377 citations

Reduced binding of TFIID to transcriptionally compromised mutants of VP16

1991 • 362 citations

RNA Polymerase B (II) And General Transcription Factors

1990 • 355 citations

Oncogenic Forms of p53 Inhibit p53-Regulated Gene Expression

1992 • 333 citations

Cloning of a Transcriptionally Active Human TATA Binding Factor

1990 • 332 citations

Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element.

1992 • 328 citations

Physical Analysis of Transcription Preinitiation Complex Assembly on a Class II Gene Promoter

1988 • 320 citations

The Zta trans-activator protein stabilizes TFIID association with promoter DNA by direct protein-protein interaction.

1991 • 249 citations

Factors involved in specific transcription by mammalian RNA polymerase II. Identification and characterization of factor IIH.

1992 • 230 citations

p53 Functions as a Cell Cycle Control Protein in Osteosarcomas

1990 • 224 citations

The MCK enhancer contains a p53 responsive element.

1991 • 170 citations

The mouse c-rel protein has an N-terminal regulatory domain and a C-terminal transcriptional transactivation domain.

1990 • 164 citations

The mammalian TFIID protein is present in two functionally distinct complexes.

1991 • 142 citations

A potential transcriptional activation element in the p53 protein.

1990 • 129 citations

Factors involved in specific transcription by mammalian RNA polymerase II: identification of general transcription factor TFIIG.

1990 • 92 citations

Factors (TAFs) required for activated transcription interact with TATA box-binding protein conserved core domain.

1993 • 89 citations

Factors involved in specific transcription by mammalian RNA polymerase II: purification and analysis of transcription factor IIA and identification of transcription factor IIJ.

1992 • 60 citations

Molecular Basis for Heterogeneity of the Human p53 Protein

1986 • 58 citations

Wild-type p53 activates transcription in vitro

1992 • 26 citations