P53 activity is essential for normal development in Xenopus

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Normal Table of Xenopus Laevis (Daudin)

1958 • 4,561 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1992 • 3,110 citations

Normal table of Xenopus laevis (Daudin)

1995 • 2,955 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

1994 • 2,460 citations

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1996 • 2,304 citations

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

1989 • 2,081 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos

1996 • 1,827 citations

MyoD or Myf-5 is required for the formation of skeletal muscle

1993 • 1,663 citations

A major developmental transition in early xenopus embryos: I. characterization and timing of cellular changes at the midblastula stage

1982 • 1,635 citations

Functional messenger RNAs are produced by SP6in vitrotranscription of cloned cDNAs

1984 • 1,533 citations

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1995 • 1,401 citations

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

1995 • 1,263 citations

A major developmental transition in early xenopus embryos: II. control of the onset of transcription

1982 • 1,065 citations

Expression of a xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction

1991 • 980 citations

Regulation of the specific DNA binding function of p53

1992 • 914 citations

Gain of function mutations in p53

1993 • 876 citations

Molecular nature of Spemann's organizer: the role of the Xenopus homeobox gene goosecoid

1991 • 799 citations

Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation

1984 • 761 citations

p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells.

1996 • 738 citations

Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53

1984 • 606 citations

Different phenotypes for mice deficient in either activins or activin receptor type II

1995 • 598 citations

Functional analysis of activins during mammalian development

1995 • 579 citations

A subset of p53-deficient embryos exhibit exencephaly

1995 • 577 citations

A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos

1992 • 538 citations

Fate map for the 32-cell stage ofXenopus laevis

1987 • 500 citations

p53 in growth control and neoplasia

1996 • 488 citations

High-frequency developmental abnormalities in p53-deficient mice

1995 • 464 citations

The mRNA encoding elongation factor 1-α (EF-1α) is a major transcript at the midblastula transition in Xenopus

1989 • 395 citations

Monoclonal antibodies identify blastemal cells derived from dedifferentiating muscle in newt limb regeneration

1984 • 353 citations

The tumore suppressor p53

1993 • 336 citations

Physical and functional interaction between WT1 and p53 proteins.

1993 • 308 citations

Transgenic mice with p53-responsive lacZ: p53activity varies dramatically during normal development and determines radiation and drug sensitivity invivo

1997 • 270 citations

Expression of p53 during mouse embryogenesis

1991 • 249 citations

A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53–deficient mice

1995 • 233 citations

Overproduction of p53 antigen makes established cells highly tumorigenic

1985 • 217 citations

A functionally inactive p53 protein interatocarcinoma cells is activated by either DNA damage or cellular differentiation

1996 • 209 citations

Involvement of p21ras in Xenopus mesoderm induction

1992 • 207 citations

The p53 response to ionising radiation in adult and developing murine tissues.

1996 • 206 citations

p53 Plays a Regulatory Role in Differentiation and Apoptosis of Central Nervous System-Associated Cells

1996 • 199 citations

Geldanamycin selectively destabilizes and conformationally alters mutated p53.

1995 • 185 citations

Biochemical properties and biological effects of p53

1995 • 183 citations

Selective disruption of E-cadherin function in early Xenopus embryos by a dominant negative mutant

1994 • 176 citations

Involvement of wild-type p53 in pre-B-cell differentiation in vitro.

1991 • 168 citations

Identification of a developmental timer regulating the stability of embryonic cyclin A and a new somatic A-type cyclin at gastrulation.

1995 • 168 citations

Transgenic mouse model for studying the transcriptional activity of the p53 protein: age- and tissue-dependent changes in radiation-induced activation during embryogenesis

1997 • 168 citations

Chapter 20 Assays for Gene Function in Developing Xenopus Embryos

1991 • 149 citations

In VivoRegulation of the Early Embryonic Cell Cycle inXenopus

1996 • 148 citations

Development of the Xenopus Pronephric System

1995 • 138 citations

Stability of RNA in developing Xenopus embryos and identification of a destabilizing sequence in TFIIIA messenger RNA

1988 • 138 citations

Interference with p53 protein inhibits hematopoietic and muscle differentiation.

1996 • 130 citations

Wild-type p53 transgenic mice exhibit altered differentiation of the ureteric bud and possess small kidneys.

1996 • 123 citations

Regulation of the cellular p53 tumor antigen in teratocarcinoma cells and their differentiated progeny.

1982 • 111 citations

Anti-apoptotic activity of low levels of wild-type p53.

1996 • 109 citations

Adenomatous Polyposis Coli Tumor Suppressor Protein Has Signaling Activity in Xenopus laevis Embryos Resulting in the Induction of an Ectopic Dorsoanterior Axis

1997 • 108 citations

Tumour suppressors: A developing role for p53?

1997 • 104 citations

Wilms' tumor suppressor gene is involved in the development of disparate kidney forms: Evidence from expression in theXenopus Pronephros

1996 • 66 citations

Does wild-type p53 play a role in normal cell differentiation?

1994 • 59 citations

Accelerated neuronal differentiation induced by p53 suppression

1996 • 58 citations

Dosage‐dependent dominance over wild‐type p53 of a mutant p53 isolated from nasopharyngeal carcinoma ¹

1993 • 54 citations

Overexpression of wild-type p53 interferes with normal development in Xenopus laevis embryos.

1994 • 53 citations

Growth cone interactions with a glial cell line from embryonic Xenopus retina

1989 • 48 citations

AP-1/Jun Is Required for Early Xenopus Development and Mediates Mesoderm Induction by Fibroblast Growth Factor but Not by Activin

1996 • 45 citations

Stabilization and Expression of High Levels of p53 during Early Development in Xenopus laevis

1993 • 40 citations

Induction of Mesoderm by a Viral Oncogene in Early Xenopus Embryos

1989 • 39 citations

Regulation of the Cellular p53 Tumor Antigen in Teratocarcinoma Cells and Their Differentiated Progeny

1982 • 35 citations

The properties of p53 proteins selected for the loss of suppression of transformation.

1994 • 23 citations

Xenopus p53 is biochemically similar to the human tumour suppressor protein p53 and is induced upon DNA damage in somatic cells.

1994 • 22 citations

Xenopus laevis p53 protein: sequence-specific DNA binding, transcriptional regulation and oligomerization are evolutionarily conserved.

1995 • 20 citations