Mammalian ABC Transporters in Health and Disease

ABC Transporters: From Microorganisms to Man

1992 • 3,956 citations

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

1992 • 3,039 citations

Identification of a Nuclear Receptor for Bile Acids

1999 • 2,537 citations

Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

2000 • 2,358 citations

The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype

2001 • 2,274 citations

A multidrug resistance transporter from human MCF-7 breast cancer cells

1998 • 2,273 citations

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

Bile Acids: Natural Ligands for an Orphan Nuclear Receptor

1999 • 2,142 citations

BIOCHEMICAL, CELLULAR, AND PHARMACOLOGICAL ASPECTS OF THE MULTIDRUG TRANSPORTER

1999 • 2,049 citations

A Family of Drug Transporters: the Multidrug Resistance-Associated Proteins

2000 • 1,723 citations

Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency

1999 • 1,708 citations

The Human ATP-Binding Cassette (ABC) Transporter Superfamily

2001 • 1,705 citations

Accumulation of Dietary Cholesterol in Sitosterolemia Caused by Mutations in Adjacent ABC Transporters

2000 • 1,626 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 • 1,547 citations

Endogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BAR

1999 • 1,528 citations

The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease

1999 • 1,527 citations

Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1

1999 • 1,441 citations

Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

1993 • 1,437 citations

Use of Arsenic Trioxide (As2O3 ) in the Treatment of Acute Promyelocytic Leukemia (APL): II. Clinical Efficacy and Pharmacokinetics in Relapsed Patients

1997 • 1,431 citations

Regulation of Absorption and ABC1-Mediated Efflux of Cholesterol by RXR Heterodimers

2000 • 1,285 citations

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

2001 • 1,271 citations

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

1996 • 1,268 citations

Putative X-linked adrenoleukodystrophy gene shares unexpected homology with ABC transporters

1993 • 1,175 citations

PPAR-α and PPAR-γ activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway

2001 • 1,134 citations

Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues.

2001 • 1,116 citations

The Human ATP-Binding Cassette (ABC) Transporter Superfamily

2001 • 1,110 citations

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

1995 • 1,109 citations

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.

1998 • 1,058 citations

A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport

2001 • 1,050 citations

A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis

1998 • 980 citations

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

1997 • 934 citations

The Sister of P-glycoprotein Represents the Canalicular Bile Salt Export Pump of Mammalian Liver

1998 • 933 citations

P-Glycoprotein, a gatekeeper in the blood–brain barrier

1999 • 918 citations

Structural Biology of Rad50 ATPase

2000 • 900 citations

Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines.

1997 • 889 citations

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

1997 • 871 citations

MDR1 P-Glycoprotein Is a Lipid Translocase of Broad Specificity, While MDR3 P-Glycoprotein Specifically Translocates Phosphatidylcholine

1996 • 863 citations

Insights into the Function of Rim Protein in Photoreceptors and Etiology of Stargardt's Disease from the Phenotype in abcr Knockout Mice

1999 • 854 citations

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

2001 • 830 citations

Congenital Jaundice in Rats with a Mutation in a Multidrug Resistance-Associated Protein Gene

1996 • 827 citations

Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes.

1999 • 810 citations

A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance.

1998 • 798 citations

Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance

1999 • 796 citations

Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells.

1994 • 777 citations

Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects

2001 • 757 citations

Human Bile Salt Export Pump Promoter Is Transactivated by the Farnesoid X Receptor/Bile Acid Receptor

2001 • 753 citations

Is the multidrug transporter a flippase?

1992 • 720 citations

Mutations in the MDR 3 gene cause progressive familial intrahepatic cholestasis

1998 • 718 citations

Insolubility of lipids in Triton X-100: physical origin and relationship to sphingolipid/cholesterol membrane domains (rafts)

2000 • 677 citations

Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine*

1997 • 675 citations

Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells.

1999 • 663 citations

The ATP-dependent glutathione S-conjugate export pump

1992 • 656 citations

Humanized xenobiotic response in mice expressing nuclear receptor SXR

2000 • 655 citations

The multidrug resistance protein family

1999 • 654 citations

Role of Breast Cancer Resistance Protein in the Bioavailability and Fetal Penetration of Topotecan

2000 • 640 citations

MRP3, an organic anion transporter able to transport anti-cancer drugs

1999 • 639 citations

Structure of MsbA from E. coli : A Homolog of the Multidrug Resistance ATP Binding Cassette (ABC) Transporters

2001 • 626 citations

Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA.

1998 • 621 citations

St John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4

2000 • 587 citations

MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs

1999 • 579 citations

Mutations in ABCC6 cause pseudoxanthoma elasticum

2000 • 575 citations

Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

2000 • 573 citations

A Novel Model of Inflammatory Bowel Disease: Mice Deficient for the Multiple Drug Resistance Gene,mdr1a, Spontaneously Develop Colitis

1998 • 570 citations

Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein

1992 • 567 citations

Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver

2000 • 565 citations

P-glycoprotein and multidrug resistance

1996 • 549 citations

Expression of P-glycoprotein in human placenta: relation to genetic polymorphism of the multidrug resistance (MDR)-1 gene.

2001 • 538 citations

Mutations in a gene encoding an ABC transporter cause pseudoxanthoma elasticum

2000 • 531 citations

A general pattern for substrate recognition by P‐glycoprotein

1998 • 530 citations

Choroid plexus epithelial expression of MDR 1 P glycoprotein and multidrug resistance-associated protein contribute to the blood–cerebrospinal-fluid drug-permeability barrier

1999 • 529 citations

Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane

1999 • 496 citations

The wide spectrum of multidrug resistance 3 deficiency: From neonatal cholestasis to cirrhosis of adulthood

2001 • 496 citations

Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein.

2000 • 494 citations

Overexpression of the BCRP/MXR/ABCP gene in a topotecan-selected ovarian tumor cell line.

1999 • 475 citations

Tissue distribution of the multidrug resistance protein.

1996 • 473 citations

Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs

2000 • 473 citations

ATP-binding Cassette Transporter A1 (ABCA1) Functions as a Cholesterol Efflux Regulatory Protein

2001 • 471 citations

The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues.

1989 • 467 citations

The Leukotriene C4 Transporter MRP1 Regulates CCL19 (MIP-3β, ELC)–Dependent Mobilization of Dendritic Cells to Lymph Nodes

2000 • 456 citations

Positively Cooperative Sites for Drug Transport by P‐Glycoprotein with Distinct Drug Specificities

1997 • 450 citations

Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2.

1999 • 444 citations

The Multidrug Resistance Protein 5 Functions as an ATP-dependent Export Pump for Cyclic Nucleotides

2000 • 438 citations

The catalytic cycle of P‐glycoprotein

1995 • 432 citations

Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein

1997 • 432 citations

The major substrates for TAP in vivo are derived from newly synthesized proteins

2000 • 408 citations

Structural, mechanistic and clinical aspects of MRP1

1999 • 408 citations

P-glycoprotein—A mediator of multidrug resistance in tumour cells

1996 • 406 citations

Characterization of vincristine transport by the M(r) 190,000 multidrug resistance protein (MRP): evidence for cotransport with reduced glutathione.

1998 • 392 citations

Pseudoxanthoma elasticum: Mutations in the MRP6 gene encoding a transmembrane ATP-binding cassette (ABC) transporter

2000 • 390 citations

Transport of Cyclic Nucleotides and Estradiol 17-β-d-Glucuronide by Multidrug Resistance Protein 4

2001 • 389 citations

Multidrug resistance transporters and modulation

2000 • 388 citations

P-glycoprotein: a defense mechanism limiting oral bioavailability and CNS accumulation of drugs

2000 • 382 citations

Disrupted Bile Acid Homeostasis Reveals an Unexpected Interaction among Nuclear Hormone Receptors, Transporters, and Cytochrome P450

2001 • 381 citations

Mechanisms of bile formation, hepatic uptake, and biliary excretion.

1984 • 375 citations

Toxicological relevance of the multidrug resistance protein 1, MRP1 (ABCC1) and related transporters

2001 • 374 citations

Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome

1996 • 372 citations

Expression of human MRP6, a homologue of the multidrug resistance protein gene MRP1, in tissues and cancer cells.

1999 • 362 citations

Transporter-Mediated Permeation of Drugs Across the Blood–Brain Barrier

2000 • 361 citations

ABC proteins : from bacteria to man

2003 • 360 citations

Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier

2000 • 358 citations

Penetration of Dexamethasone into Brain Glucocorticoid Targets Is Enhanced in mdr1A P-Glycoprotein Knockout Mice*

1998 • 355 citations

The mouse Bcrp1/Mxr/Abcp gene: amplification and overexpression in cell lines selected for resistance to topotecan, mitoxantrone, or doxorubicin.

1999 • 353 citations

Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure

1999 • 352 citations

Retinal Stimulates ATP Hydrolysis by Purified and Reconstituted ABCR, the Photoreceptor-specific ATP-binding Cassette Transporter Responsible for Stargardt Disease

1999 • 351 citations

Characterization of the Transport Properties of Cloned Rat Multidrug Resistance-associated Protein 3 (MRP3)

1999 • 349 citations

Mice with homozygous disruption of the mdr2 P-glycoprotein gene. A novel animal model for studies of nonsuppurative inflammatory cholangitis and hepatocarcinogenesis.

1994 • 346 citations

Overexpression of the ATP-binding cassette half-transporter, ABCG2 (Mxr/BCrp/ABCP1), in flavopiridol-resistant human breast cancer cells.

2001 • 338 citations

Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database

1996 • 338 citations

Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1).

1992 • 335 citations

ATP-dependent Transport of Bile Salts by Rat Multidrug Resistance-associated Protein 3 (Mrp3)

2000 • 333 citations

Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein

1992 • 328 citations

Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

1997 • 326 citations

Cellular Localization and Trafficking of the Human ABCA1 Transporter

2001 • 326 citations

MDR3 gene defect in adults with symptomatic intrahepatic and gallbladder cholesterol cholelithiasis

2001 • 320 citations

The MRP2/cMOAT Transporter and Arsenic-Glutathione Complex Formation Are Required for Biliary Excretion of Arsenic

2000 • 320 citations

The ABC transporter proteins Pat1 and Pat2 are required for import of long-chain fatty acids into peroxisomes of Saccharomyces cerevisiae.

1996 • 319 citations

Functional Multidrug Resistance Protein (MRP1) Lacking the N-terminal Transmembrane Domain

1998 • 318 citations

Targeted inactivation of sister of P-glycoprotein gene ( spgp ) in mice results in nonprogressive but persistent intrahepatic cholestasis

2001 • 312 citations

Functional Characterization of the Human Multidrug Transporter, ABCG2, Expressed in Insect Cells

2001 • 310 citations

Placental P-glycoprotein deficiency enhances susceptibility to chemically induced birth defects in mice

1998 • 308 citations

P-Glycoprotein Protects Leukemia Cells Against Caspase-Dependent, but not Caspase-Independent, Cell Death

1999 • 308 citations

The Crystal Structure of the DNA-Binding Domain of Yeast RAP1 in Complex with Telomeric DNA

1996 • 306 citations

Multiple physiological functions for multidrug transporter P-glycoprotein?

2000 • 305 citations

Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin C.

1998 • 301 citations

ABC transporters in lipid transport

2000 • 300 citations

Stimulation of P‐glycoprotein‐mediated drug transport by prazosin and progesterone

1999 • 299 citations

The 220-kDa Rim Protein of Retinal Rod Outer Segments Is a Member of the ABC Transporter Superfamily

1997 • 297 citations

Expression of the conjugate export pump encoded by the mrp2 gene in the apical membrane of kidney proximal tubules.

1997 • 294 citations

The ATP binding cassette transporter ABC1, is required for the engulfment of corpses generated by apoptotic cell death.

1996 • 294 citations

Further Evidence for an Association of ABCR Alleles with Age-Related Macular Degeneration

2000 • 293 citations

Reversal of resistance by GF120918 in cell lines expressing the ABC half-transporter, MXR

1999 • 291 citations

ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump

1996 • 290 citations

Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine

2000 • 288 citations

Cellular localization and up-regulation of multidrug resistance–associated protein 3 in hepatocytes and cholangiocytes during obstructive cholestasis in rat liver

2001 • 285 citations

Up-regulation of basolateral multidrug resistance protein 3 (Mrp3) in cholestatic rat liver

2001 • 284 citations

Modulation and prevention of multidrug resistance by inhibitors of P-glycoprotein

1997 • 281 citations

Substantial excretion of digoxin via the intestinal mucosa and prevention of long‐term digoxin accumulation in the brain by the mdrla P‐glycoprotein

1996 • 278 citations

The Effect of Rifampin Treatment on Intestinal Expression of Human MRP Transporters

2000 • 278 citations

Structure–activity relationship of P-glycoprotein substrates and modifiers

2000 • 277 citations

Evidence that the multidrug resistance protein (MRP) functions as a co-transporter of glutathione and natural product toxins.

1997 • 277 citations

Multidrug resistance mediated by a bacterial homolog of the human multidrug transporter MDR1.

1996 • 275 citations

Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833.

1997 • 272 citations

The homodimeric ATP-binding cassette transporter LmrA mediates multidrug transport by an alternating two-site (two-cylinder engine) mechanism

2000 • 267 citations

Hepatic expression of multidrug resistance-associated protein-like proteins maintained in eisai hyperbilirubinemic rats.

1998 • 265 citations

Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells.

1996 • 262 citations

Cloning of Two Novel ABC Transporters Mapping on Human Chromosome 9

1994 • 262 citations

Camptothecin resistance: role of the ATP-binding cassette (ABC), mitoxantrone-resistance half-transporter (MXR), and potential for glucuronidation in MXR-expressing cells.

1999 • 259 citations

Role of ABCG1 and other ABCG family members in lipid metabolism

2001 • 256 citations

Characterization of Drug Transport by the Human Multidrug Resistance Protein 3 (ABCC3)

2001 • 255 citations

Characterization of inducible nature of MRP3 in rat liver

2000 • 255 citations

Role of the human Y box-binding protein YB-1 in cellular sensitivity to the DNA-damaging agents cisplatin, mitomycin C, and ultraviolet light.

1996 • 251 citations

A canalicular multispecific organic anion transporter (cMOAT) antisense cDNA enhances drug sensitivity in human hepatic cancer cells.

1997 • 249 citations

Phytosterolaemia, xanthomatosis and premature atherosclerotic arterial disease: a case with high plant sterol absorption, impaired sterol elimination and low cholesterol synthesis

1980 • 249 citations

Enhancement of chemotherapeutic drug toxicity to human tumour cells in vitro by a subset of non-steroidal anti-inflammatory drugs (NSAIDs)

1998 • 249 citations

Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport.

2001 • 249 citations

Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione

1999 • 246 citations

MDR3 P-glycoprotein, a Phosphatidylcholine Translocase, Transports Several Cytotoxic Drugs and Directly Interacts with Drugs as Judged by Interference with Nucleotide Trapping

2000 • 246 citations

Sitosterolemia.

1992 • 244 citations

Sterol absorption and sterol balance in phytosterolemia evaluated by deuterium-labeled sterols: effect of sitostanol treatment.

1995 • 242 citations

Gene redundancy and pharmacological gene therapy: Implications for X-linked adrenoleukodystrophy

1998 • 242 citations

Disruption of the murine MRP (multidrug resistance protein) gene leads to increased sensitivity to etoposide (VP-16) and increased levels of glutathione.

1997 • 241 citations

Circumvention of breast cancer resistance protein (BCRP)-mediated resistance to camptothecins in vitro using non-substrate drugs or the BCRP inhibitor GF120918.

2001 • 237 citations

Transport of amphipathic anions by human multidrug resistance protein 3.

2000 • 237 citations

Identification of a sister gene to P-glycoprotein.

1995 • 236 citations

Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects

2001 • 235 citations

Expression and localization of multidrug resistant protein mrp2 in rat small intestine.

2000 • 235 citations

A bacterial antibiotic-resistance gene that complements the human multidrug-resistance P-glycoprotein gene

1998 • 234 citations

Expression of various multidrug resistance-associated protein (MRP) homologues in brain microvessel endothelial cells

2000 • 233 citations

A physiologic function for p-glycoprotein (MDR-1) during the migration of dendritic cells from skin via afferent lymphatic vessels

1998 • 232 citations

Modulation of Multidrug Resistance Protein 1 (MRP1/ABCC1) Transport and ATPase Activities by Interaction with Dietary Flavonoids

2001 • 231 citations

Active Secretion of Drugs from the Small Intestinal Epithelium in Rats by P-Glycoprotein Functioning as an Absorption Barrier

1996 • 229 citations

Analysis of the MRP4 Drug Resistance Profile in Transfected NIH3T3 Cells

2000 • 227 citations

Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export

2000 • 226 citations

Involvement of P-glycoprotein in the transmembrane transport of interleukin-2 (IL-2), IL-4, and interferon-gamma in normal human T lymphocytes

1996 • 225 citations

ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice

2001 • 222 citations

Transport Function and Hepatocellular Localization of mrp6 in Rat Liver

2000 • 218 citations

Multidrug resistance proteins MRP3, MRP1, and MRP2 in lung cancer: correlation of protein levels with drug response and messenger RNA levels.

2001 • 217 citations

Regulation of biliary lipid secretion by mdr2 P-glycoprotein in the mouse.

1995 • 217 citations

cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3)¹

1998 • 214 citations

Delayed dark-adaptation and lipofuscin accumulation in abcr+/- mice: implications for involvement of ABCR in age-related macular degeneration.

2001 • 214 citations

Inhibitory effect of the reversal agents V-104, GF120918 and Pluronic L61 on MDR1 Pgp-, MRP1- and MRP2-mediated transport

2000 • 212 citations

Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoprotein

2000 • 210 citations

Subunit interactions in ABC transporters: towards a functional architecture

1999 • 209 citations

Specific Docking of Apolipoprotein A-I at the Cell Surface Requires a Functional ABCA1 Transporter

2001 • 209 citations

Characterization of the ATPase Activity of Purified Chinese Hamster P-glycoprotein

1994 • 207 citations

Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies.

2000 • 206 citations

Role of the ABC Transporter Mdl1 in Peptide Export from Mitochondria

2001 • 205 citations

GS-X pump is functionally overexpressed in cis-diamminedichloroplatinum (II)-resistant human leukemia HL-60 cells and down-regulated by cell differentiation.

1994 • 204 citations

ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice

2001 • 204 citations

P-Glycoprotein Deficiency in a Subpopulation of CF-1 Mice Enhances Avermectin-Induced Neurotoxicity

1997 • 203 citations

Coadministration of oral cyclosporin A enables oral therapy with paclitaxel.

1999 • 202 citations

Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833

1997 • 201 citations

Coadministration of Cyclosporine Strongly Enhances the Oral Bioavailability of Docetaxel

2001 • 200 citations

Multidrug Resistance Protein 1 Protects the Oropharyngeal Mucosal Layer and the Testicular Tubules against Drug-induced Damage

1998 • 200 citations

MRP6 (ABCC6) Detection in Normal Human Tissues and Tumors

2002 • 197 citations

Extensive contribution of the multidrug transporters P-glycoprotein and Mrp1 to basal drug resistance.

2000 • 196 citations

pABC11 (Also Known as MOAT-C and MRP5), a Member of the ABC Family of Proteins, Has Anion Transporter Activity but Does Not Confer Multidrug Resistance When Overexpressed in Human Embryonic Kidney 293 Cells

1999 • 196 citations

Multidrug resistance in Lactococcus lactis: evidence for ATP-dependent drug extrusion from the inner leaflet of the cytoplasmic membrane.

1996 • 194 citations

Relation Between the Turnover Number for Vinblastine Transport and for Vinblastine-stimulated ATP Hydrolysis by Human P-glycoprotein

1997 • 190 citations

The multidrug resistance and cystic fibrosis genes have complementary patterns of epithelial expression.

1992 • 190 citations

Expression of the multidrug resistance proteins MRP2 and MRP3 in human hepatocellular carcinoma

2001 • 188 citations

Identification of a Locus for Progressive Familial Intrahepatic Cholestasis PFIC2on Chromosome 2q24

1997 • 188 citations

Peptide Mimetic HIV Protease Inhibitors Are Ligands for the Orphan Receptor SXR

2001 • 188 citations

Defining the Drug-binding Site in the Human Multidrug Resistance P-glycoprotein Using a Methanethiosulfonate Analog of Verapamil, MTS-verapamil

2001 • 185 citations

The Product of the ABC Half-Transporter Gene ABCG2 (BCRP/MXR/ABCP) Is Expressed in the Plasma Membrane

2000 • 184 citations

Introduction to the Blood-Brain Barrier

1998 • 180 citations

Expression of multidrug resistance protein-3 (multispecific organic anion transporter-D) in human embryonic kidney 293 cells confers resistance to anticancer agents.

1999 • 178 citations

Analysis of the structure and expression pattern of MRP7 (ABCC10), a new member of the MRP subfamily

2001 • 176 citations

Competition of Hydrophobic Peptides, Cytotoxic Drugs, and Chemosensitizers on a Common P-glycoprotein Pharmacophore as Revealed by Its ATPase Activity

1996 • 176 citations

Comparison of the Functional Characteristics of the Nucleotide Binding Domains of Multidrug Resistance Protein 1

2000 • 175 citations

Transporters on Demand

2001 • 175 citations

Structure of the ArsA ATPase: the catalytic subunit of a heavy metal resistance pump

2000 • 175 citations

Extraction of Hoechst 33342 from the Cytoplasmic Leaflet of the Plasma Membrane by P‐Glycoprotein

1997 • 170 citations

Expression of multidrug resistance protein-related genes in lung cancer: correlation with drug response.

1999 • 168 citations

Effects of Ursodeoxycholate and cholate feeding on liver disease in FVB mice with a disrupted mdr2 P-glycoprotein gene

1996 • 167 citations

Kinetics of Steady-state Currents and Charge Movements Associated with the Rat Na+/Glucose Cotransporter

1995 • 166 citations

The photoreceptor rim protein is an ABC transporter encoded by the gene for recessive Stargardt's disease (ABCR)

1997 • 164 citations

Reconstitution of ATP-dependent Leukotriene C4 Transport by Co-expression of Both Half-molecules of Human Multidrug Resistance Protein in Insect Cells

1996 • 162 citations

The multidrug resistance protein MRP1 mediates the release of glutathione disulfide from rat astrocytes during oxidative stress

2001 • 161 citations

Role of MRP2 and GSH in intrahepatic cycling of toxins

2001 • 161 citations

Mutation of a Single Conserved Tryptophan in Multidrug Resistance Protein 1 (MRP1/ABCC1) Results in Loss of Drug Resistance and Selective Loss of Organic Anion Transport

2001 • 160 citations

Transport of the β-O-Glucuronide Conjugate of the Tobacco-specific Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the Multidrug Resistance Protein 1 (MRP1)

2001 • 160 citations

Glutathione Stimulates Sulfated Estrogen Transport by Multidrug Resistance Protein 1

2001 • 159 citations

The Structure of the Multidrug Resistance Protein 1 (MRP1/ABCC1)

2001 • 158 citations

Hepatic secretion of phospholipid vesicles in the mouse critically depends on mdr2 or MDR3 P-glycoprotein expression. Visualization by electron microscopy.

1997 • 157 citations

Identification of a Novel Human Sterol-Sensitive ATP-Binding Cassette Transporter (ABCA7)

2000 • 157 citations

Genetic Polymorphism in MDR-1: A Tool for Examining Allelic Expression in Normal Cells, Unselected and Drug-Selected Cell Lines, and Human Tumors

1998 • 157 citations

The human multidrug resistance protein MRP1 translocates sphingolipid analogs across the plasma membrane

1999 • 156 citations

Phospholipid Flippase Activity of the Reconstituted P-Glycoprotein Multidrug Transporter

2001 • 156 citations

A Saccharomyces cerevisiae homolog of the human adrenoleukodystrophy transporter is a heterodimer of two half ATP-binding cassette transporters.

1996 • 155 citations

Verapamil stimulates glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1).

2000 • 154 citations

Steroid Transport, Accumulation, and Antagonism of P-Glycoprotein in Multidrug-Resistant Cells

1996 • 154 citations

Hepatobiliary cholesterol transport is not impaired in Abca1-null mice lacking HDL

2001 • 151 citations

Characterization of the Catalytic Cycle of ATP Hydrolysis by Human P-glycoprotein

2001 • 151 citations

Modulation of oral bioavailability of anticancer drugs: from mouse to man

2000 • 147 citations

Inhibition of BCRP-mediated drug efflux by fumitremorgin-type indolyl diketopiperazines

2001 • 145 citations

Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter.

1998 • 145 citations

Taxol resistance mediated by transfection of the liver-specific sister gene of P-glycoprotein.

1998 • 144 citations

Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12

2001 • 144 citations

MOAT-E (ARA) is a full-length MRP/cMOAT subfamily transporter expressed in kidney and liver

1999 • 143 citations

Anticancer drug resistance in primary human brain tumors

2001 • 142 citations

The Purified and Functionally Reconstituted Multidrug Transporter LmrA of Lactococcus lactis Mediates the Transbilayer Movement of Specific Fluorescent Phospholipids

1999 • 140 citations

P-Glycoprotein mediates the efflux of quinidine across the blood-brain barrier.

1997 • 140 citations

Involvement of an organic anion transporter (canalicular multispecific organic anion transporter/multidrug resistance-associated protein 2) in gastrointestinal secretion of glutathione conjugates in rats.

2000 • 139 citations

P‐Glycoprotein‐Mediated Hoechst 33342 Transport Out of the Lipid Bilayer

1997 • 138 citations

Indomethacin-mediated reversal of multidrug resistance and drug efflux in human and murine cell lines overexpressing MRP, but not P-glycoprotein

1997 • 138 citations

The Functional Role of P-Glycoprotein in the Blood–Brain Barrier

1997 • 138 citations

Phosphatidylcholine and Phosphatidylethanolamine Behave as Substrates of the Human MDR1 P-Glycoprotein

1997 • 136 citations

Role of Multidrug Resistance P-glycoproteins in Cholesterol Esterification

1997 • 134 citations

The Role of Phosphoinositide 3-Kinase in Taurocholate-induced Trafficking of ATP-dependent Canalicular Transporters in Rat Liver

1998 • 131 citations

ATP hydrolysis cycles and mechanism inP-glycoprotein and CFTR

1997 • 130 citations

Hepatobiliary cholesterol transport is not impaired in Abca1-null mice lacking HDL

2001 • 130 citations

Increased Bioavailability of the Food-Derived Carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in MRP2-Deficient Rats

2001 • 130 citations

Newly Synthesized Canalicular ABC Transporters Are Directly Targeted from the Golgi to the Hepatocyte Apical Domain in Rat Liver

2000 • 130 citations

Identification of genes differentially expressed in breast cancer cells treated with tamoxifen, using microarray-based expression profiling

2001 • 129 citations

How does P-glycoprotein recognize its substrates?

1997 • 128 citations

Abnormal metabolism of shellfish sterols in a patient with sitosterolemia and xanthomatosis.

1986 • 127 citations

Simple and Complex ABCR: Genetic Predisposition to Retinal Disease

2000 • 127 citations

The Transmembrane Domains of the Human Multidrug Resistance P-glycoprotein Are Sufficient to Mediate Drug Binding and Trafficking to the Cell Surface

1999 • 126 citations

Molecular cloning and characterization of the murine bile salt export pump

2000 • 124 citations

Cloning and expression of murine sister of P-glycoprotein reveals a more discriminating transporter than MDR1/P-glycoprotein.

2000 • 124 citations

Identification of a P-Glycoprotein-Deficient Subpopulation in the CF-1 Mouse Strain Using a Restriction Fragment Length Polymorphism

1997 • 123 citations

Hepatocyte-specific expression of the humanMDR3P-glycoprotein gene restores the biliary phosphatidylcholine excretion absent inMdr2 (?/?) mice

1998 • 123 citations

ATP-dependent transport of glutathione S-conjugates by the multidrug resistance protein MRP1 and its apical isoform MRP2

1998 • 121 citations

Assessment of active transport of HIV protease inhibitors in various cell lines and the in vitro blood–brain barrier

2001 • 120 citations

Transport of fatty acids and metabolites across the peroxisomal membrane

2000 • 120 citations

Restoration of TNF-α-induced ceramide generation and apoptosis in resistant human leukemia KG1a cells by the P-glycoprotein blocker PSC833

1998 • 117 citations

Brain drug delivery, drug metabolism, and multidrug resistance at the choroid plexus

2000 • 115 citations

Multidrug Resistance (MDR1) P-glycoprotein Enhances Esterification of Plasma Membrane Cholesterol

1999 • 115 citations

P-glycoprotein confers methotrexate resistance in 3T6 cells with deficient carrier-mediated methotrexate uptake.

1996 • 108 citations

P-Glycoprotein Shows Strong Catalytic Cooperativity between the Two Nucleotide Sites

1998 • 107 citations

Altered expression of hepatic cytochromes P-450 in mice deficient in one or more mdr1 genes.

2000 • 106 citations

Mrp2 is essential for estradiol-17β(β-D -glucuronide)–induced cholestasis in rats

2000 • 103 citations

Characterization of the mouse bile salt export pump overexpressed in the baculovirus system

2001 • 102 citations

Role of P‐Glycoprotein in the Blood‐Brain Transport of Colchicine and Vinblastine

1996 • 101 citations

Phosphoinositide 3-kinase lipid products regulate ATP-dependent transport by sister of P-glycoprotein and multidrug resistance associated protein 2 in bile canalicular membrane vesicles

1999 • 100 citations

The (patho)physiological functions of the MRP family

2000 • 99 citations

Suppression of peroxisomal membrane protein defects by peroxisomal ATP binding cassette (ABC) proteins

1998 • 97 citations

Multidrug transporters from bacteria to man: similarities in structure and function

1997 • 97 citations

Characterization of the 5′‐flanking region of the human multidrug resistance protein 2 (MRP2) gene and its regulation in comparison withthe multidrug resistance protein 3 (MRP3) gene

2000 • 96 citations

Nonequivalent Nucleotide Trapping in the Two Nucleotide Binding Folds of the Human Multidrug Resistance Protein MRP1

2000 • 96 citations

Double knockout of the MRP gene leads to increased drug sensitivity in vitro.

1996 • 95 citations

Monoclonal antibodies against P-glycoprotein, an MDR1 gene product, inhibit interleukin-2 release from PHA-activated lymphocytes.

1996 • 93 citations

Roles of MRP2 and oatp1 in Hepatocellular Export of Reduced Glutathione

1998 • 92 citations

Organic anion transport across the choroid plexus

2000 • 91 citations

Phase II Study of Paclitaxel and Valspodar (PSC 833) in Refractory Ovarian Carcinoma: A Gynecologic Oncology Group Study

2001 • 91 citations

Intronic Enhancer Activity of the Eosinophil-derived Neurotoxin (RNS2) and Eosinophil Cationic Protein (RNS3) Genes Is Mediated by an NFAT-1 Consensus Binding Sequence

1997 • 90 citations

MDR1 gene–related clonal selection and P-glycoprotein function and expression in relapsed or refractory acute myeloid leukemia

2001 • 90 citations

Interaction of bioactive hydrophobic peptides with the human multidrug transporter

1994 • 90 citations

The multidrug resistance P-glycoprotein modulates cell regulatory volume decrease.

1996 • 89 citations

Intracellular Trafficking and Regulation of Canalicular ATP-Binding Cassette Transporters

2000 • 88 citations

The pharmacological phenotype of combined multidrug-resistance mdr1a/1b- and mrp1-deficient mice.

2001 • 87 citations

The role of mdr1a P-glycoprotein in the biliary and intestinal secretion of doxorubicin and vinblastine in mice.

2000 • 87 citations

Complete Coding Sequence, Promoter Region, and Genomic Structure of the Human ABCA2 Gene and Evidence for Sterol-Dependent Regulation in Macrophages

2001 • 87 citations

The Packing of the Transmembrane Segments of Human Multidrug Resistance P-glycoprotein Is Revealed by Disulfide Cross-linking Analysis

2000 • 87 citations

Penetration of Dexamethasone into Brain Glucocorticoid Targets Is Enhanced in mdr1A P-Glycoprotein Knockout Mice

1998 • 85 citations

Identification of an Amino Acid Residue in Multidrug Resistance Protein 1 Critical for Conferring Resistance to Anthracyclines

2001 • 85 citations

Mrp2-deficiency in the rat impairs biliary and intestinal excretion and influences metabolism and disposition of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

2001 • 85 citations

Inhibition of the intestinal digoxin absorption and exsorption by quinidine.

1996 • 84 citations

ABCA6, a Novel A Subclass ABC Transporter

2001 • 83 citations

Multidrug-resistance P-glycoprotein (MDR1) secretes platelet-activating factor

2001 • 82 citations

Kinetic and biochemical analysis of carrier-mediated efflux of drugs through the blood–brain and blood–cerebrospinal fluid barriers: importance in the drug delivery to the brain

1999 • 82 citations

Flip-Flop of Doxorubicin across Erythrocyte and Lipid Membranes

1997 • 81 citations

The multi‐drug resistance reversal agent SR33557 and modulation of vinca alkaloid binding to P‐glycoprotein by an allosteric interaction

1997 • 81 citations

Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione

1999 • 81 citations

Genes and cholestasis

2001 • 81 citations

Pharmacologic interactions between the resistance‐modifying cyclosporine sdz psc 833 and etoposide (VP 16–213) enhance In Vivo cytostatic activity and toxicity

1992 • 80 citations

Identification of Basic Residues Involved in Drug Export Function of Human Multidrug Resistance-associated Protein 2

2000 • 80 citations

Multidrug resistance p-glycoprotein 2 is essential for the biliary excretion of indocyanine green.

2001 • 80 citations

Cloning and regulation of the ratmdr2gene

1993 • 79 citations

A phase I trial of doxorubicin, paclitaxel, and valspodar (PSC 833), a modulator of multidrug resistance.

2001 • 79 citations

Structure-activity relationships for xenobiotic transport substrates and inhibitory ligands of P-glycoprotein.

1997 • 79 citations

DeterminingMDR1/P-glycoprotein expression in breast cancer

2001 • 78 citations

A structure-based mechanism for drug binding by multidrug transporters

2000 • 78 citations

Monoclonal Antibodies That Inhibit the Transport Function of the 190-kDa Multidrug Resistance Protein, MRP

1999 • 77 citations

Sex‐dependent and independent expression of the P‐glycoprotein isoforms in Chinese hamster

1990 • 74 citations

Availability of PSC833, a substrate and inhibitor of P-glycoproteins, in various concentrations of serum

1998 • 73 citations

Class III P-glycoproteins mediate the formation of lipoprotein X in the mouse.

1998 • 73 citations

Fibrate induction of the adrenoleukodystrophy‐related gene (ABCD2)

2001 • 71 citations

Membrane Transporters as Drug Targets

2002 • 71 citations

Anthracyclines modulate multidrug resistance protein (MRP) mediated organic anion transport

1997 • 70 citations

Molecular dissection of the human multidrug resistance P-glycoprotein

1999 • 70 citations

Steroid and nuclear receptors Villefranche-sur-Mer, France, May 25–27, 1999

1999 • 70 citations

Mice Lacking the Multidrug Resistance Protein 1 Are Resistant to Streptococcus pneumoniae-Induced Pneumonia

2001 • 68 citations

Specific MDR1 P-Glycoprotein Blockade Inhibits Human Alloimmune T Cell Activation In Vitro

2001 • 68 citations

Biliary Secretion of α-Tocopherol and the Role of the mdr2 P-Glycoprotein in Rats and Mice

1998 • 68 citations

Secretion of Platelet-Activating Factor Is Mediated by MDR1 P-Glycoprotein in Cultured Human Mesangial Cells

1999 • 67 citations

Drug resistance-associated factors in primary and secondary glioblastomas and their precursor tumors.

2000 • 65 citations

Function and regulation of ATP-binding cassette transport proteins involved in hepatobiliary transport

2000 • 65 citations

Exploring the structure and function of the P-glycoprotein multidrug transporter using fluorescence spectroscopic tools

2001 • 65 citations

The anthracycline resistance-associated (ara) gene, a novel gene associated with multidrug resistance in a human leukaemia cell line

1996 • 64 citations

Phase I/II Trial of the Multidrug-Resistance Modulator Valspodar Combined With Cisplatin and Doxorubicin in Refractory Ovarian Cancer

2001 • 62 citations

The uncoupling of biliary lipid from bile acid secretion by organic anions in the rat

1990 • 62 citations

Arsenic induces expression of the multidrug resistance-associated protein 2 (MRP2) gene in primary rat and human hepatocytes.

2001 • 62 citations

Clinical reversal of drug resistance

1995 • 61 citations

Adenosine triphosphate-dependent transport of estradiol-17?(?-d-glucuronide) in membrane vesicles by MDR1 expressed in insect cells

1998 • 61 citations

Future perspectives for the development of P-glycoprotein modulators

1998 • 61 citations

Involvement of glutathione in 1-naphthylisothiocyanate (ANIT) metabolism and toxicity to isolated hepatocytes

1991 • 61 citations

ATP-dependent export pumps and their inhibition by cyclosporins

1994 • 59 citations

Effect of the P-glycoprotein inhibitor, SDZ PSC 833, on the blood and brain pharmacokinetics of colchicine

1997 • 57 citations

Regulation of mdr2 P-glycoprotein expression by bile salts

1997 • 56 citations

Cholesterol Interaction with the Daunorubicin Binding Site of P-Glycoprotein

2000 • 56 citations

Cyclic AMP Stimulates the Cyclic GMP Egression Pump in Human Erythrocytes: Effects of Probenecid, Verapamil, Progesterone, Theophylline, IBMX, Forskolin, and Cyclic AMP on Cyclic GMP Uptake and Association to Inside-Out Vesicles

1998 • 56 citations

Targeted inactivation of sister of P-glycoprotein gene (spgp) in mice results in nonprogressive but persistent intrahepatic cholestasis

2001 • 56 citations

LOW BIOAVAILABILITY OF CYCLOSPORINE MICROEMULSION AND TACROLIMUS IN A SMALL BOWEL TRANSPLANT RECIPIENT

1999 • 55 citations

Expression and immunolocalization of multidrug resistance protein 2 in rabbit small intestine

2000 • 54 citations

Disruption of mdr1a p-glycoprotein gene results in dysfunction of blood–inner ear barrier in mice

2000 • 50 citations

Genomic organization and characterization of the promoter of the human ATP-binding cassette transporter-G1 (ABCG1) gene

2000 • 50 citations

Molecular dissection of the human multidrug resistance P-glycoprotein

1999 • 50 citations

Multidrug resistance-associated protein 3 is a tumor rejection antigen recognized by HLA-A2402-restricted cytotoxic T lymphocytes.

2001 • 47 citations

Role of glycine-534 and glycine-1179 of human multidrug resistance protein (MDR1) in drug-mediated control of ATP hydrolysis

2001 • 47 citations

Multidrug Resistance in Pediatric Malignancies

1995 • 47 citations

Kinetics of glutathione and daunorubicin efflux from multidrug resistance protein overexpressing small-cell lung cancer cells

2001 • 46 citations

Nature of the base sequence conserved in the mitochondrial DNA of a low-density petite

1973 • 45 citations

Head–head/tail–tail relative orientation of the pore-forming domains of the heterodimeric ABC transporter TAP

2000 • 45 citations

Resistance of human multidrug resistance-associated protein 1-overexpressing lung tumor cells to the anticancer drug arsenic trioxide11Abbreviations: MRP1, multidrug resistance-associated protein 1; As2O3, arsenic trioxide; MTT, 3-(4-5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; and BSO, buthionine sulfoximine.

2001 • 45 citations

A New Structural Model for P-Glycoprotein

1998 • 45 citations

Affinity, Specificity, Diversity: A Challenge for the ABC Transporter TAP in Cellular Immunity

2000 • 43 citations

Function and regulation of ATP-binding cassette transport proteins involved in hepatobiliary transport

2001 • 43 citations

Enhancement of glucuronosyl etoposide transport by glutathione in multidrug resistance-associated protein-overexpressing cells

1998 • 40 citations

Use of chimeric proteins to investigate the role of transporter associated with antigen processing (TAP) structural domains in peptide binding and translocation

2001 • 40 citations

Growth and Cell Cycle Abnormalities of Fibroblasts From Tangier Disease Patients

1999 • 38 citations

Biosynthesis and intracellular transport of a bile canalicular plasma membrane protein: Studiesin vivo and in the perfused rat liver

1994 • 37 citations

Gene expression of sterol regulatory element-binding proteins in hamster small intestine

2001 • 36 citations

Highly sensitive and specific detection of P-glycoprotein function for haematological and solid tumour cells using a novel nucleic acid stain

1997 • 35 citations

Introduction: Multidrug resistant proteins

1997 • 35 citations

Effects of Retroviral‐Mediated MDR1 Expression on Hematopoietic Stem Cell Self‐Renewal and Differentiation in Culture^a

1999 • 32 citations

ABCI, the mammalian homologue of the engulfment gene ced-7, is required during phagocytosis of both necrotic and apoptotic cells

1998 • 32 citations

P-Glycoprotein-Mediated Colchicine Resistance in Different Cell Lines Correlates with the Effects of Colchicine on P-Glycoprotein Conformation

2001 • 31 citations

Recognition of multiple drugs by a single protein: a trivial solution of an old paradox

2000 • 31 citations

Inhibitors of MRP1-mediated multidrug resistance

1998 • 29 citations

An analysis by electron microscopy of intermediates in the replication of linear Tetrahymena mitochondrial DNA

1974 • 29 citations

Transition-State Formation in ATPase-Negative Mutants of Human MDR1 Protein

2000 • 28 citations

P-glycoprotein Does Not Protect Cells against Cytolysis Induced by Pore-forming Proteins

2001 • 28 citations

How does TAP pump peptides? Insights from DNA repair and traffic ATPases

2000 • 27 citations

Can multidrug resistance mechanisms be modified?

2000 • 25 citations

Use of real‐time gene‐specific polymerase chain reaction to measure RNA expression of three family members of rat cytochrome P450 4A

2001 • 24 citations

ARA,a Novel ABC Transporter, Is Located at 16p13.1, Is Deleted in inv(16) Leukemias, and Is Shown To Be Expressed in Primitive Hematopoietic Precursors

1998 • 22 citations

[26] P-glycoprotein and swelling-activated chloride channels

1998 • 22 citations

Amplification and expression of the ABC transporters ARA and MRP in a series of multidrug-resistant leukaemia cell sublines

1998 • 22 citations

10 Multidrug resistance in acute myeloid leukaemia

1996 • 21 citations

Profound differences in the transport of steroids by two mouse P-glycoproteins

1999 • 21 citations

Expression of multidrug resistance protein 1 (MRP1) in the rat cochlea with special reference to the blood–inner ear barrier

2001 • 20 citations

Multidrug ABC transporters from bacteria to man: an emerging hypothesis for the universality of molecular mechanism and function

1998 • 20 citations

Evidence for the Vectorial Nature of Drug (Substrate)-stimulated ATP Hydrolysis by Human P-glycoprotein

2001 • 19 citations

Blood–brain barrier transport of drugs

1998 • 16 citations

New physiological functions for drug-transporting P-glycoproteins?

1998 • 13 citations

Recognition of multiple drugs by a single protein: a trivial solution of an old paradox

2000 • 13 citations

Structure-Activity Relationships for Xenobiotic Transport Substrates and Inhibitory Ligands of P-Glycoprotein

1997 • 9 citations

P-glycoprotein, a guardian of the brain

1998 • 8 citations

Determining MDR1P‐glycoprotein expression in breast cancer

2001 • 6 citations

Organic anion transport across the choroid plexus

2001 • 4 citations

Role of Multidrug Resistance Proteins (MRP) in Resistance to Antifolates and Folate Homeostasis

2002 • 2 citations

Expression of a Non-MDR2-Coded Liver Phosphatidylcholine Membrane Transport Protein inXenopus laevisOocytes

1997 • 2 citations

Lipid translocation by multidrug transporters

2001 • 1 citations