ATP-dependent export pumps and their inhibition by cyclosporins

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells.

1988 • 480 citations

In vivo circumvention of P-glycoprotein-mediated multidrug resistance of tumor cells with SDZ PSC 833.

1991 • 364 citations

The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles

1989 • 329 citations

ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. Role of the ATP-dependent transport system for glutathione S-conjugates.

1990 • 299 citations

Expression of the Multidrug-Resistant Gene in Hepatocarcinogenesis and Regenerating Rat Liver

1987 • 274 citations

Identification of the multidrug resistance-related P-glycoprotein as a cyclosporine binding protein.

1989 • 242 citations

Cyclosporins as drug resistance modifiers

1992 • 205 citations

Rat liver canalicular membrane vesicles contain an ATP-dependent bile acid transport system.

1991 • 203 citations

ATP-dependent transport of taurocholate across the hepatocyte canalicular membrane mediated by a 110-kDa glycoprotein binding ATP and bile salt.

1991 • 176 citations

Competitive interaction of cyclosporins with the Vinca alkaloid-binding site of P-glycoprotein in multidrug-resistant cells.

1990 • 167 citations

Multidrug Resistance

1989 • 166 citations

ATP-dependent bile-salt transport in canalicular rat liver plasma-membrane vesicles

1992 • 144 citations

mdr2 encodes P-glycoprotein expressed in the bile canalicular membrane as determined by isoform-specific antibodies.

1992 • 141 citations

ATP-dependent taurocholate transport by rat liver canalicular membrane vesicles*1, *2

1991 • 136 citations

ATP-dependent S-(2,4-dinitrophenyl)glutathione transport in canalicular plasma membrane vesicles from rat liver

1991 • 132 citations

Differential inhibition by cyclosporins of primary‐active ATP‐dependent transporters in the hepatocyte canalicular membrane

1993 • 128 citations

Inhibition by cyclosporin A of Adenosine triphosphate-dependent transport from the hepatocyte into bile

1993 • 104 citations

The rat liver ecto-ATPase is also a canalicular bile acid transport protein.

1993 • 101 citations

Cyclosporin A-induced cholestasis. The mechanism in a rat model.

1987 • 93 citations

Leukotrienes: Biosynthesis, transport, inactivation, and analysis

1992 • 90 citations

Cyclosporin A-induced cholestasis

1987 • 87 citations

Cloning and regulation of the ratmdr2gene

1993 • 79 citations

Inhibition of hepatocytary vesicular transport by cyclosporin a in the rat: Relationship with cholestasis and hyperbilirubinemia

1990 • 71 citations

ATP‐dependent leukotriene export from mastocytoma cells

1991 • 64 citations

CHOLESTATIC EFFECT OF CYCLOSPORINE IN THE RAT AN INHIBITION OF BILE ACID SECRETION

1988 • 62 citations

Liver-function studies in heart-transplant recipients treated with cyclosporin A.

1988 • 29 citations

Liver-function studies in heart-transplant recipients treated with cyclosporin A.

1988 • 28 citations

SDZ PSC 833 and SDZ 280–446 are the most active of various resistance-modifying agents in restoring rhodamine-123 retention within multidrug resistant P388 cells

1992 • 20 citations