The Functional Role of P-Glycoprotein in the Blood–Brain Barrier

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

1996 • 1,268 citations

Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability

1980 • 799 citations

The Blood-brain Barrier: Principles for Targeting Peptides and Drugs to the Central Nervous System

1996 • 283 citations

Substantial excretion of digoxin via the intestinal mucosa and prevention of long‐term digoxin accumulation in the brain by the mdrla P‐glycoprotein

1996 • 278 citations

Interstitial taxol delivered from a biodegradable polymer implant against experimental malignant glioma.

1994 • 208 citations

A method to determine the ability of drugs to diffuse through the blood-brain barrier.

1994 • 195 citations

Altered Pharmacokinetics of Vinblastine in Mdr1a P-glycoprotein-Deficient Mice

1996 • 175 citations

Pharmacological considerations in the modulation of multidrug resistance

1996 • 139 citations

Do anticancer agents reach the tumor target in the human brain?

1992 • 133 citations

Clinical modulation of doxorubicin resistance by the calmodulin-inhibitor, trifluoperazine: a phase I/II trial.

1988 • 124 citations

Osmotic blood-brain barrier disruption and chemotherapy in the treatment of high grade malignant glioma: patient series and literature review

1992 • 123 citations

Isolation and culture of human brain microvessel endothelial cells for the study of blood-brain barrier properties in vitro

1995 • 102 citations

Role of P‐Glycoprotein in the Blood‐Brain Transport of Colchicine and Vinblastine

1996 • 101 citations

Decreased biotolerability for ivermectin and cyclosporin a in mice exposed to potent P‐glycoprotein inhibitors

1995 • 73 citations

Intravenous RMP-7 selectively increases uptake of carboplatin into rat brain tumors.

1996 • 70 citations

Intrathecal vincristine: a fatal chemotherapeutic error with devastating central nervous system effects

1991 • 41 citations

Decreased potency of MDR‐modulators under serum conditions determined by a functional assay

1995 • 31 citations

Neurotoxicity of adriamycin passed through the transiently disrupted blood-brain barrier by mannitol in the rat brain

1987 • 28 citations

Serum can inhibit reversal of multidrug resistance by chemosensitisers

1996 • 25 citations

Modulation effects of cyclosporine on etoposide pharmacokinetics and CNS distribution in the rat utilizing microdialysis

1996 • 16 citations

Malignant Brain Tumors

2014 • 1 citations