Gene expression of sterol regulatory element-binding proteins in hamster small intestine

Regulation of the mevalonate pathway

1990 • 5,282 citations

The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor

1997 • 3,702 citations

Adipogenesis and Obesity: Rounding Out the Big Picture

1996 • 1,268 citations

ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism.

1996 • 1,004 citations

SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

1994 • 994 citations

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.

1997 • 816 citations

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.

1996 • 802 citations

Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells.

1997 • 744 citations

Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.

1998 • 686 citations

Sterol-Regulated Release of SREBP-2 from Cell Membranes Requires Two Sequential Cleavages, One Within a Transmembrane Segment

1996 • 515 citations

Gastrointestinal Disease: Pathophysiology, Diagnosis, Management.

1984 • 512 citations

Sterol synthesis in vivo in 18 tissues of the squirrel monkey, guinea pig, rabbit, hamster, and rat

1983 • 414 citations

Two Tandem Binding Sites for Sterol Regulatory Element Binding Proteins Are Required for Sterol Regulation of Fatty-acid Synthase Promoter

1996 • 331 citations

Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver.

1995 • 305 citations

Effect of cholesterol feeding and fasting on sterol synthesis in seventeen tissues of the rat

1967 • 296 citations

Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13

1995 • 291 citations

Sterol-dependent Transcriptional Regulation of Sterol Regulatory Element-binding Protein-2

1996 • 274 citations

Sterol regulation of acetyl coenzyme A carboxylase: a mechanism for coordinate control of cellular lipid.

1996 • 257 citations

Rates of receptor-dependent and -independent low density lipoprotein uptake in the hamster.

1983 • 230 citations

Cleavage Site for Sterol-regulated Protease Localized to a Leu-Ser Bond in the Lumenal Loop of Sterol Regulatory Element-binding Protein-2

1997 • 170 citations

Sterol regulatory element binding protein binds to a cis element in the promoter of the farnesyl diphosphate synthase gene.

1996 • 159 citations

Hairpin Orientation of Sterol Regulatory Element-binding Protein-2 in Cell Membranes as Determined by Protease Protection

1995 • 153 citations

Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver

1997 • 149 citations

Evidence for a contribution by the intestinal wall to the serum cholesterol of the rat

1965 • 119 citations

Structure of the Human Gene Encoding Sterol Regulatory Element Binding Protein 2 (SREBF2)

1997 • 117 citations

Regulatory effects of dietary sterols and bile acids on rat intestinal HMG CoA reductase

1973 • 81 citations

Cholesterol synthesis and low density lipoprotein uptake are regulated independently in rat small intestinal epithelium.

1983 • 79 citations

Regulation of Rabbit Intestinal Acyl Coenzyme A-Cholesterol Acyltransferase In Vivo and In Vitro

1982 • 79 citations

Regulation of cholesterol metabolism in the intestine

1990 • 78 citations

A fluorescent cholesterol analog traces cholesterol absorption in hamsters and is esterified in vivo and in vitro

1999 • 77 citations

Localization of 3-hydroxy-3-methylglutaryl CoA reductase and 3-hydroxy-3-methylglutaryl CoA synthase in the rat liver and intestine is affected by cholestyramine and mevinolin

1988 • 64 citations

Synthesis and coenzyme A-dependent esterification of cholesterol in rat intestinal epithelium. Differences in cellular localization and mechanisms of regulation.

1983 • 60 citations

3-Hydroxy-3-methylglutaryl coenzyme A reductase in isolated villous and crypt cells of the rat ileum

1977 • 59 citations

Absolute rates of cholesterol synthesis in rat intestine in vitro and in vivo: a comparison of different substrates in slices and isolated cells

1983 • 57 citations

Transcriptional Control Mechanisms in the Regulation of Cholesterol Balance

1995 • 50 citations

The Site of Absorption of Cholesterol and Sitosterol in the Rat Small Intestine

1970 • 50 citations

Influence of Streptozotocin Diabetes on Intestinal 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Activity in the Rat

1977 • 38 citations

The effects of feeding a saturated fat-rich diet on enzymes of cholesterol metabolism in the liver, intestine and aorta of the hamster

1990 • 35 citations

Sterol synthesis in intestinal villi and crypt cells of rats and guinea pigs

1977 • 35 citations

Effect of Cholesterol Feeding on Circadian Rhythm of Hepatic and Intestinal Cholesterol Biosynthesis in Hamsters

1975 • 35 citations

Isolated rabbit enterocytes as a model cell system for investigations of chylomicron assembly and secretion

1999 • 29 citations

Location and regulation of low-density lipoprotein receptors in intestinal epithelium

1995 • 17 citations

Serum response element-like sequences of the human low density lipoprotein receptor promoter: possible regulation sites for sterol-independent transcriptional activation.

1996 • 13 citations

Detection of thymidine kinase activity using an assay based on the precipitation of nucleoside monophosphates with lanthanum chloride

1989 • 12 citations

Hydroxymethylglutaryl-coenzyme A reductase exhibits graded distribution in normal and mevinolin-treated ileum.

1987 • 12 citations