Disruption of mdr1a p-glycoprotein gene results in dysfunction of blood–inner ear barrier in mice

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

1989 • 1,744 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 • 1,547 citations

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

1996 • 1,268 citations

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

1995 • 1,109 citations

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

1997 • 871 citations

Isolation and expression of a complementary DNA that confers multidrug resistance

1986 • 808 citations

The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues.

1989 • 467 citations

Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities.

1990 • 420 citations

Modulation of multidrug-resistant multiple myeloma by cyclosporin

1992 • 317 citations

Cloning and characterization of a second member of the mouse mdr gene family.

1988 • 268 citations

Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells

1989 • 241 citations

Kinetics of gentamicin uptake and release in the rat. Comparison of inner ear tissues and fluids with other organs.

1986 • 240 citations

Altered Pharmacokinetics of Vinblastine in Mdr1a P-glycoprotein-Deficient Mice

1996 • 175 citations

Labyrinthine Barriers and Cochlear Homeostasis

1981 • 167 citations

Cisplatin‐Induced Ototoxicity: The Effect of Pigmentation and Inhibitory Agents

1993 • 154 citations

Increased accumulation of doxorubicin and doxorubicinol in cardiac tissue of mice lacking mdr1a P-glycoprotein

1998 • 141 citations

Nature of Blood-Labyrinth Barrier in Experimental Conditions

1981 • 120 citations

Barrier Systems in the Inner Ear

1988 • 91 citations

The blood-perilymph barrier

1980 • 90 citations

Toxic Effects of Adriamycin on the Ganglia of the Peripherial Nervous System: A Neuropathological Study

1977 • 86 citations

Ototoxic mechanisms: A Working Hypothesis

1973 • 66 citations

Cyclosporin A markedly changes the distribution of doxorubicin in mice and rats.

1994 • 63 citations

Transport characteristics of the blood—Perilymph barrier

1982 • 58 citations

Mechanisms of Central Conduction Time Prolongation in Brain-Stem Auditory Evoked Potentials

1986 • 56 citations

Permeability changes of the blood-labyrinth barrier measured in vivo during experimental treatments

1992 • 54 citations

Multidrug resistance-reversing agents increase vinblastine distribution in normal tissues expressing the P-glycoprotein but do not enhance drug penetration in brain and testis.

1997 • 52 citations

Block of axoplasmic transport in vitro by vinca alkaloids

1980 • 49 citations

Cytofluorescence localization of adriamycin in the nervous system

1982 • 47 citations

Characterization of P-glycoprotein transport and inhibition in vivo.

1998 • 40 citations

Expression of P-glycoprotein in inner ear capillary endothelial cells of the guinea pig with special reference to blood–inner ear barrier

1997 • 22 citations

Cisplatin Metabolites and their Toxicity on Isolated Cochlear Outer Hair Cells in Vitro

1996 • 17 citations

Auditory Brainstem Response (ABR) Latency Shifts in Animal Models of Various Types of Conductive and Sensori-neural Hearing Losses

1991 • 16 citations

Similar Pharmacokinetics and Differential Ototoxicity after Administration with Cisplatin and Transplatin in Guinea Pigs

1997 • 15 citations

Same location of the source of P1 of BAEPs and N1 of CAP in guinea pig

1991 • 11 citations

Kinetic experiments with radionuclides concerning the perilymph-blood barrier in a guinea pig model

1989 • 10 citations

Changes in the electrochemical composition of cochlear fluids after intracisternal application of doxorubicin in the rat

1992 • 9 citations