Choroid plexus epithelial expression of MDR 1 P glycoprotein and multidrug resistance-associated protein contribute to the blood–cerebrospinal-fluid drug-permeability barrier

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1992 • 3,039 citations

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

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The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.

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1990 • 970 citations

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

1997 • 934 citations

MDR1 P-Glycoprotein Is a Lipid Translocase of Broad Specificity, While MDR3 P-Glycoprotein Specifically Translocates Phosphatidylcholine

1996 • 863 citations

The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump.

1994 • 685 citations

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1988 • 516 citations

Tissue distribution of the multidrug resistance protein.

1996 • 473 citations

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1990 • 386 citations

Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug resistant lung cancer cell lines

1994 • 315 citations

Immunochemical detection of the multidrug resistance-associated protein MRP in human multidrug-resistant tumor cells by monoclonal antibodies.

1994 • 284 citations

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1994 • 276 citations

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1989 • 266 citations

Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells.

1996 • 262 citations

Disruption of the murine MRP (multidrug resistance protein) gene leads to increased sensitivity to etoposide (VP-16) and increased levels of glutathione.

1997 • 241 citations

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1990 • 239 citations

Multidrug resistance mediated by the multidrug resistance protein (MRP) gene

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1992 • 210 citations

Expression of multidrug resistance-associated protein in NIH/3T3 cells confers multidrug resistance associated with increased drug efflux and altered intracellular drug distribution.

1995 • 208 citations

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1996 • 182 citations

99mTc-sestamibi is a substrate for P-glycoprotein and the multidrug resistance-associated protein

1998 • 141 citations

The choroid plexus epithelium is the site of the organic anion transport protein in the brain

1997 • 140 citations

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1993 • 136 citations

Chemosensitization and drug accumulation effects of VX-710, verapamil, cyclosporin A, MS-209 and GF120918 in multidrug resistant HL60/ADR cells expressing the multidrug resistance-associated protein MRP

1997 • 134 citations

Multidrug Resistance (MDR1) P-glycoprotein Enhances Esterification of Plasma Membrane Cholesterol

1999 • 115 citations

Characterization of Multidrug Resistance P-Glycoprotein Transport Function with an Organotechnetium Cation

1995 • 113 citations

Thallium-201 versus technetium-99m-MIBI SPECT in evaluation of childhood brain tumors: a within-subject comparison.

1993 • 111 citations

Location of a protease-hypersensitive region in the multidrug resistance protein (MRP) by mapping of the epitope of MRP-specific monoclonal antibody QCRL-1.

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Functional characterization of choroid plexus epithelial cells in primary culture.

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Monoclonal antibody MRK16 reverses the multidrug resistance of multidrug-resistant transgenic mice.

1992 • 55 citations

Characterization of Phosphine Complexes of Technetium(III) as Transport Substrates of the Multidrug Resistance P-Glycoprotein and Functional Markers of P-Glycoprotein at the Blood−Brain Barrier

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Practical aspects of using microdialysis for determination of brain interstitial concentrations

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Evidence for cytoplasmic P-glycoprotein location associated with increased multidrug resistance and resistance to chemosensitizers.

1996 • 43 citations

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Serotonin agonists increase transferrin levels via activation of 5-HT1C receptors in choroid plexus epithelium

1992 • 29 citations

Relationship between in vitro transendothelial permeability and in vivo single-pass brain extraction.

1994 • 23 citations