Cloning and expression of murine sister of P-glycoprotein reveals a more discriminating transporter than MDR1/P-glycoprotein.

The scanning model for translation: an update.

1989 • 3,525 citations

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

1996 • 1,268 citations

A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis

1998 • 980 citations

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

1997 • 934 citations

The Sister of P-glycoprotein Represents the Canalicular Bile Salt Export Pump of Mammalian Liver

1998 • 933 citations

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

1997 • 871 citations

Choroid plexus epithelial expression of MDR 1 P glycoprotein and multidrug resistance-associated protein contribute to the blood–cerebrospinal-fluid drug-permeability barrier

1999 • 529 citations

Fluorescent cellular indicators are extruded by the multidrug resistance protein.

1993 • 496 citations

Intrahepatic cholestasis of pregnancy: A French prospective study

1997 • 323 citations

Functional Multidrug Resistance Protein (MRP1) Lacking the N-terminal Transmembrane Domain

1998 • 318 citations

Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833.

1997 • 272 citations

Interindividual variation in expression of P-glycoprotein in normal human liver and secondary hepatic neoplasms.

1995 • 254 citations

Identification of a sister gene to P-glycoprotein.

1995 • 236 citations

Kinetic Analysis of Calcein and Calcein−Acetoxymethylester Efflux Mediated by the Multidrug Resistance Protein and P-Glycoprotein

1998 • 186 citations

Ranking of P-glycoprotein substrates and inhibitors by a calcein-AM fluorometry screening assay

1996 • 185 citations

Taxol resistance mediated by transfection of the liver-specific sister gene of P-glycoprotein.

1998 • 144 citations

Modulation of P-glycoprotein-mediated drug transport by alterations in lipid fluidity of rat liver canalicular membrane vesicles.

1992 • 143 citations

Molecular basis of preferential resistance to colchicine in multidrug-resistant human cells conferred by Gly-185----Val-185 substitution in P-glycoprotein.

1990 • 143 citations

Inducible, High-Level Production of Infectious Murine Leukemia Retroviral Vector Particles Pseudotyped with Vesicular Stomatitis Virus G Envelope Protein

1995 • 136 citations

Physical mapping, amplification, and overexpression of the mouse mdr gene family in multidrug-resistant cells.

1990 • 129 citations

Interaction of bioactive hydrophobic peptides with the human multidrug transporter

1994 • 90 citations

An Improved Method for Generating Retroviral Producer Clones for Vectors Lacking a Selectable Marker Gene

1998 • 84 citations

Phylogenic and ontogenic expression of hepatocellular bile acid transport.

1993 • 83 citations

Characterization of a cDNA encoding a new member of the glucocorticoid-responsive cytochromes P450 in human liver

1989 • 81 citations

Kinetic analysis of hepatobiliary transport of vincristine in perfused rat liver

1992 • 70 citations

Efflux of taurocholic acid across the blood-brain barrier: interaction with cyclic peptides.

1998 • 66 citations

Mammalian multidrug-resistance gene: correlation of exon organization with structural domains and duplication of an ancestral gene.

1989 • 62 citations

Extracellular matrix regulation of multidrug resistance in primary monolayer cultures of adult rat hepatocytes.

1993 • 59 citations

Alteration of Substrate Specificity by Mutations at the His⁶¹ Position in Predicted Transmembrane Domain 1 of Human MDR1/P-Glycoprotein

1997 • 52 citations

Ontogenic expression of the Na+-independent organic anion transporting polypeptide (oatp) in rat liver and kidney

1996 • 47 citations

Mosaic evolution of prepropancreatic polypeptide.

1986 • 46 citations

CHOLESTATIC EFFECTS OF CYCLOSPORINE IN THE RAT1

1997 • 45 citations

Mosaic evolution of prepropancreatic polypeptide. II. Structural conservation and divergence in pancreatic polypeptide gene.

1988 • 38 citations

Divergent regulation of the class II P-glycoprotein gene in primary cultures of hepatocytes versus H35 hepatoma by glucocorticoids.

1995 • 36 citations

Sister of P-glycoprotein expression in different tissues

1999 • 35 citations

A Comparative Study of Bile Acid Metabolism in the Rat, Mouse, Hamster, and Gerbil

1969 • 28 citations

[14] Functional assays for analysis of yeast ste6 mutants

1998 • 28 citations

Functional Interactions between Synthetic Alkyl Phospholipids and the ABC Transporters P-Glycoprotein, Ste-6, MRP, and Pgh-1

1999 • 24 citations

Tauro-β-muricholate preserves choleresis and prevents taurocholate-induced cholestasis in colchicine-treated rat liver

1992 • 22 citations

Characterization of the hepatic canalicular membrane transport of a model oligopeptide: ditekiren.

1997 • 15 citations

Role of bile salts in colchicine-induced hepatotoxicity. Implications for hepatocellular integrity and function

1997 • 8 citations