Flip-Flop of Doxorubicin across Erythrocyte and Lipid Membranes

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation.

1978 • 2,254 citations

Transport and Diffusion Across Cell Membranes

1986 • 1,042 citations

[16] Preparation of impermeable ghosts and inside-out vesicles from human erythrocyte membranes

1974 • 1,028 citations

The multidrug transporter, a double-edged sword.

1988 • 763 citations

Is the multidrug transporter a flippase?

1992 • 720 citations

Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells.

1990 • 386 citations

Kinetics of Gramicidin Channel Formation in Lipid Bilayers: Transmembrane Monomer Association

1990 • 232 citations

Characterization of the ATPase Activity of Purified Chinese Hamster P-glycoprotein

1994 • 207 citations

The blood-brain barrier. Transport across the cerebral endothelium.

1985 • 184 citations

The Role of Passive Transbilayer Drug Movement in Multidrug Resistance and Its Modulation

1996 • 183 citations

Local sequence requirements for DNA cleavage by mammalian topoisomerase II in the presence of doxorubicin

1990 • 181 citations

Accumulation of doxorubicin and other lipophilic amines into large unilamellar vesicles in response to transmembrane pH gradients

1993 • 168 citations

Unidirectional fluxes of rhodamine 123 in multidrug-resistant cells: evidence against direct drug extrusion from the plasma membrane.

1994 • 111 citations

Transport Studies of Doxorubicin in Model Membranes Indicate a Difference in Passive Diffusion across and Binding at the Outer and Inner Leaflet of the Plasma Membrane

1994 • 110 citations

Cell surface actions of adriamycin

1991 • 109 citations

Functional Reconstitution of P-glycoprotein Reveals an Apparent Near Stoichiometric Drug Transport to ATP Hydrolysis

1996 • 105 citations

The interaction of adriamycin with cardiolipin in model and rat liver mitochondrial membranes

1984 • 85 citations

Channels, Carriers, and Pumps

1990 • 64 citations

Role of anionic phospholipids in the interaction of doxorubicin and plasma membrane vesicles: Drug binding and structural consequences in bacterial systems

1993 • 52 citations

Influence of cholesterol on gramicidin-induced HII phase formation in phosphatidylcholine model membranes

1988 • 37 citations