Multidrug resistance mediated by a bacterial homolog of the human multidrug transporter MDR1.

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

ABC Transporters: From Microorganisms to Man

1992 • 3,956 citations

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

Atlas of Protein Sequence and Structure, 1972.

1973 • 2,408 citations

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Prevention of Drug Access to Bacterial Targets: Permeability Barriers and Active Efflux

1994 • 1,518 citations

Structural model of ATP-binding proteing associated with cystic fibrosis, multidrug resistance and bacterial transport

1990 • 1,149 citations

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

1987 • 1,080 citations

Is the multidrug transporter a flippase?

1992 • 720 citations

The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein

1989 • 604 citations

Nucleotide sequence of an Escherichia coli chromosomal hemolysin

1985 • 572 citations

Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of P. falciparum

1989 • 570 citations

ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells.

1988 • 480 citations

GENETIC ANALYSIS OF THE MULTIDRUG TRANSPORTER

1995 • 469 citations

PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1.

1994 • 439 citations

Emr, an Escherichia coli locus for multidrug resistance.

1992 • 410 citations

Construction of plasmid cloning vectors for lactic streptococci which also replicate in Bacillus subtilis and Escherichia coli

1984 • 382 citations

Efflux-mediated multidrug resistance in Bacillus subtilis: similarities and dissimilarities with the mammalian system.

1991 • 367 citations

How cancer cells evade chemotherapy: sixteenth Richard and Hinda Rosenthal Foundation Award Lecture.

1993 • 357 citations

NEW MECHANISMS OF DRUG RESISTANCE IN PARASITIC PROTOZOA

1995 • 262 citations

A functional superfamily of sodium/solute symporters

1994 • 224 citations

A bacterial analog of the mdr gene of mammalian tumor cells is present in Streptomyces peucetius, the producer of daunorubicin and doxorubicin.

1991 • 221 citations

Mutational analysis of the yeast a-factor transporter STE6, a member of the ATP binding cassette (ABC) protein superfamily.

1991 • 188 citations

Identification and Characterization of SNQ2, a New Multidrug ATP Binding Cassette Transporter of the Yeast Plasma Membrane

1995 • 161 citations

The essential Escherichia coli msbA gene, a multicopy suppressor of null mutations in the htrB gene, is related to the universally conserved family of ATP‐dependent translocators

1993 • 153 citations

The Lactococcal lmrP Gene Encodes a Proton Motive Force- dependent Drug Transporter

1995 • 119 citations

Proton motive force-driven and ATP-dependent drug extrusion systems in multidrug-resistant Lactococcus lactis

1994 • 105 citations

Genetic analysis of lipopolysaccharide core biosynthesis by Escherichia coli K-12: insertion mutagenesis of the rfa locus

1990 • 103 citations

A PVC-based electrode sensitive to DDA+ as a device for monitoring the membrane potential in biological systems

1978 • 99 citations

Calcium efflux from Escherichia coli. Evidence for two systems.

1984 • 83 citations

ATP‐dependent transport of amphiphilic cations across the hepatocyte canalicular membrane mediated by mdr1 P‐glycoprotein

1994 • 56 citations

Functional studies of P-glycoprotein in inside-out plasma membrane vesicles derived from murine erythroleukemia cells overexpressing MDR 3. Properties and kinetics of the interaction of vinblastine with P-glycoprotein and evidence for its active mediated transport.

1994 • 49 citations