Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells.

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

The Pharmacological Basis of Therapeutics

1976 • 8,675 citations

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

1992 • 3,039 citations

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

1989 • 1,744 citations

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

1995 • 1,109 citations

The Pharmacological Basis of Therapeutics

1976 • 894 citations

The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.

1994 • 850 citations

Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells.

1994 • 777 citations

The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump.

1994 • 685 citations

Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone.

1992 • 677 citations

The ATP-dependent glutathione S-conjugate export pump

1992 • 656 citations

Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.

1994 • 621 citations

Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein.

1995 • 501 citations

Polarity of Epithelial and Neuronal Cells

1992 • 435 citations

ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein.

1994 • 435 citations

Mechamisms of cell polarity: sorting and transport in epithelial cells

1994 • 430 citations

2 The Kidney

1969 • 412 citations

The Leukotriene LTD4 Receptor Antagonist Mk571 Specifically Modulates MRP Associated Multidrug Resistance

1995 • 402 citations

Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug resistant lung cancer cell lines

1994 • 315 citations

Immunochemical detection of the multidrug resistance-associated protein MRP in human multidrug-resistant tumor cells by monoclonal antibodies.

1994 • 284 citations

Clinical Pharmacokinetics of Probenecid

1981 • 225 citations

Characterization of the human MDR3 P-glycoprotein and its recognition by P-glycoprotein-specific monoclonal antibodies.

1991 • 212 citations

N-glycosylation and deletion mutants of the human MDR1 P-glycoprotein.

1993 • 209 citations

Biochemistry of Multidrug Resistance Mediated by the Multidrug Transporter

1993 • 209 citations

Regulation by glutathione of drug transport in multidrug-resistant human lung tumour cell lines overexpressing multidrug resistance-associated protein

1995 • 206 citations

Specificity of transporters for ‘organic anions’ and ‘organic cations’ in the kidney

1994 • 172 citations

Hepatobiliary transport of glutathione and glutathione conjugate in rats with hereditary hyperbilirubinemia.

1989 • 172 citations

Inhibitors of membrane transport system for organic anions block fura-2 excretion from PC12 and N2A cells

1988 • 153 citations

Characterization of the M(r) 190,000 multidrug resistance protein (MRP) in drug-selected and transfected human tumor cell.

1995 • 145 citations

An ion-transporting ATPase encodes multiple apical localization signals.

1993 • 129 citations

Expression of the multidrug resistance-associated protein (MRP) in acute and chronic leukemias.

1994 • 104 citations

Glutathione-conjugate transport by human colon adenocarcinoma cells (Caco-2 cells)

1993 • 47 citations

ATP-dependent Efflux of 2,4-Dinitrophenyl-S-glutathione

1995 • 34 citations