Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

THE GREEN FLUORESCENT PROTEIN

1998 • 5,991 citations

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

1992 • 3,039 citations

BIOCHEMICAL, CELLULAR, AND PHARMACOLOGICAL ASPECTS OF THE MULTIDRUG TRANSPORTER

1999 • 2,049 citations

The Liver: Biology and Pathobiology.

1983 • 1,628 citations

Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophores

1989 • 1,616 citations

Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines.

1997 • 889 citations

The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.

1994 • 850 citations

Congenital Jaundice in Rats with a Mutation in a Multidrug Resistance-Associated Protein Gene

1996 • 827 citations

Photochemically generated cytosolic calcium pulses and their detection by fluo-3

1989 • 820 citations

Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells.

1999 • 663 citations

cDNA Cloning of the Hepatocyte Canalicular Isoform of the Multidrug Resistance Protein, cMrp, Reveals a Novel Conjugate Export Pump Deficient in Hyperbilirubinemic Mutant Rats

1996 • 641 citations

MRP3, an organic anion transporter able to transport anti-cancer drugs

1999 • 639 citations

Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.

1994 • 621 citations

Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA.

1998 • 621 citations

Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump.

1996 • 569 citations

Multidrug Resistance Protein (MRP)-mediated Transport of Leukotriene C4 and Chemotherapeutic Agents in Membrane Vesicles

1996 • 555 citations

A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome

1997 • 551 citations

The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis

1997 • 502 citations

Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane

1999 • 496 citations

Tissue distribution of the multidrug resistance protein.

1996 • 473 citations

A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation.

1996 • 473 citations

Prediction of Transmembrane Segments in Proteins Utilising Multiple Sequence Alignments

1994 • 466 citations

Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2.

1999 • 444 citations

CHRONIC IDIOPATHIC JAUNDICE WITH UNIDENTIFIED PIGMENT IN LIVER CELLS

1954 • 442 citations

ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein.

1994 • 435 citations

Binary specification of nonsense codons by splicing and cytoplasmic translation

1998 • 396 citations

Characterization of vincristine transport by the M(r) 190,000 multidrug resistance protein (MRP): evidence for cotransport with reduced glutathione.

1998 • 392 citations

Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport

1995 • 385 citations

Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome

1996 • 372 citations

In vivo circumvention of P-glycoprotein-mediated multidrug resistance of tumor cells with SDZ PSC 833.

1991 • 364 citations

Expression of human MRP6, a homologue of the multidrug resistance protein gene MRP1, in tissues and cancer cells.

1999 • 362 citations

Characterization of the Transport Properties of Cloned Rat Multidrug Resistance-associated Protein 3 (MRP3)

1999 • 349 citations

Multidrug resistance mediated by the ATP-binding cassette transporter protein MRP

1998 • 343 citations

Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database

1996 • 338 citations

Reversal of P-glycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberane modulator, LY335979.

1996 • 329 citations

Functional Multidrug Resistance Protein (MRP1) Lacking the N-terminal Transmembrane Domain

1998 • 318 citations

FROM VACUOLAR GS-X PUMPS TO MULTISPECIFIC ABC TRANSPORTERS

1998 • 313 citations

ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2

1997 • 300 citations

ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. Role of the ATP-dependent transport system for glutathione S-conjugates.

1990 • 299 citations

Expression of the conjugate export pump encoded by the mrp2 gene in the apical membrane of kidney proximal tubules.

1997 • 294 citations

ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump

1996 • 290 citations

Immunochemical detection of the multidrug resistance-associated protein MRP in human multidrug-resistant tumor cells by monoclonal antibodies.

1994 • 284 citations

Expression and localization of the conjugate export pump encoded by the MRP2 (cMRP/cMOAJ) gene in liver

1997 • 269 citations

ATP-dependent 17β-Estradiol 17-(β-D-Glucuronide) Transport by Multidrug Resistance Protein (MRP)

1996 • 265 citations

Hepatic expression of multidrug resistance-associated protein-like proteins maintained in eisai hyperbilirubinemic rats.

1998 • 265 citations

Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells.

1996 • 262 citations

Mutations in the canilicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome

1998 • 259 citations

Expression of the MRP2 Gene-Encoded Conjugate Export Pump in Human Kidney Proximal Tubules and in Renal Cell Carcinoma

1999 • 257 citations

ATP‐ and glutathione‐dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1

1999 • 256 citations

Green fluorescent protein: applications in cell biology

1996 • 252 citations

A canalicular multispecific organic anion transporter (cMOAT) antisense cDNA enhances drug sensitivity in human hepatic cancer cells.

1997 • 249 citations

Transport of the flavonoid chrysin and its conjugated metabolites by the human intestinal cell line Caco-2

1999 • 249 citations

Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione

1999 • 246 citations

Membrane topology distinguishes a subfamily of the ATP‐binding cassette (ABC) transporters

1997 • 237 citations

Genomic Structure of the Canalicular Multispecific Organic Anion–Transporter Gene (MRP2/cMOAT) and Mutations in the ATP-Binding–Cassette Region in Dubin-Johnson Syndrome

1999 • 232 citations

Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes.

1995 • 230 citations

Defective ATP-dependent bile canalicular transport of organic anions in mutant (TR-) rats with conjugated hyperbilirubinemia.

1990 • 229 citations

Homologues of the human multidrug resistance genes MRP and MDR contribute to heavy metal resistance in the soil nematode Caenorhabditis elegans.

1996 • 223 citations

Membrane Topology of the Multidrug Resistance Protein (MRP)

1997 • 215 citations

cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3)¹

1998 • 214 citations

Membrane Topology and Glycosylation of the Human Multidrug Resistance-associated Protein

1996 • 209 citations

WIF-B cells: an in vitro model for studies of hepatocyte polarity.

1993 • 209 citations

Detection of the M(r) 190,000 multidrug resistance protein, MRP, with monoclonal antibodies.

1994 • 196 citations

ATP‐dependent efflux of calcein by the multidrug resistance protein (MRP): no inhibition by intracellular glutathione depletion

1995 • 196 citations

Transport properties of the multidrug resistance‐associated protein (MRP) in human tumour cells

1996 • 194 citations

ATP-Dependent Transport of Aflatoxin B₁and Its Glutathione Conjugates by the Product of the Multidrug Resistance Protein (MRP) Gene

1997 • 189 citations

Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2

1999 • 180 citations

Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein and effect on cytochrome P-450 activities.

1999 • 173 citations

PERSISTENT NONHEMOLYTIC HYPERBILIRUBINEMIA ASSOCIATED WITH LIPOCHROMELIKE PIGMENT IN LIVER CELLS: REPORT OF FOUR CASES

1954 • 172 citations

Methotrexate is excreted into the bile by canalicular multispecific organic anion transporter in rats.

1997 • 171 citations

Canalicular transport of reduced glutathione in normal and mutant Eisai hyperbilirubinemic rats.

1992 • 162 citations

Multispecific organic anion transporter is responsible for the biliary excretion of the camptothecin derivative irinotecan and its metabolites in rats.

1997 • 158 citations

Characterization of the ATP‐dependent leukotriene C₄ export carrier in mastocytoma cells

1994 • 157 citations

Exon-intron organization of the human multidrug-resistance protein 2 (MRP2) gene mutated in Dubin–Johnson syndrome

1999 • 150 citations

Genistein modulates the decreased drug accumulation in non-P-glycoprotein mediated multidrug resistant tumour cells

1993 • 146 citations

The GS-X Pump in Plant, Yeast, and Animal Cells: Structure, Function, and Gene Expression

1997 • 144 citations

Pharmacological Characterization of the Murine and Human Orthologs of Multidrug-Resistance Protein in Transfected Human Embryonic Kidney Cells

1997 • 143 citations

Hereditary defect of hepatobiliary cysteinyl leukotriene elimination in mutant rats with defective hepatic anion excretion

1987 • 143 citations

Increased levels of the multidrug resistance protein in lateral membranes of proliferating hepatocyte-derived cells

1997 • 141 citations

Biliary excretion of pravastatin in rats: contribution of the excretion pathway mediated by canalicular multispecific organic anion transporter.

1997 • 140 citations

Cyclic AMP stimulates sorting of the canalicular organic anion transporter (Mrp2/cMoat) to the apical domain in hepatocyte couplets

1998 • 139 citations

Transport of glutathione prostaglandin A conjugates by the multidrug resistance protein 1

1997 • 138 citations

ATP/Mg2+-dependent Cardiac Transport System for Glutathione S-Conjugates

1989 • 137 citations

Differential inhibition by cyclosporins of primary‐active ATP‐dependent transporters in the hepatocyte canalicular membrane

1993 • 128 citations

Topology Mapping of the Amino-terminal Half of Multidrug Resistance-associated Protein by Epitope Insertion and Immunofluorescence

1997 • 113 citations

Glutathione transport by inside-out vesicles from human erythrocytes.

1980 • 112 citations

Functional Analysis of a Canalicular Multispecific Organic Anion Transporter Cloned from Rat Liver

1998 • 109 citations

[45] Transport function and substrate specificity of multidrug resistance protein

1998 • 106 citations

Location of a protease-hypersensitive region in the multidrug resistance protein (MRP) by mapping of the epitope of MRP-specific monoclonal antibody QCRL-1.

1996 • 106 citations

Osmodependent dynamic localization of the multidrug resistance protein 2 in the rat hepatocyte canalicular membrane

1997 • 105 citations

An improved polarized rat hepatoma hybrid cell line: generation and comparison with its hepatoma relatives and hepatocytes in vivo

1994 • 105 citations

Adenosine triphosphate-dependent transport of anionic conjugates by the rabbit multidrug resistance-associated protein Mrp2 expressed in insect cells.

1998 • 102 citations

Immunohistochemical detection of multidrug resistance protein in human lung cancer and normal lung.

1998 • 98 citations

Bile canaliculus formation in cultured HEPG2 cells.

1993 • 97 citations

Export pumps for anionic conjugates encoded by MRP genes

1999 • 95 citations

Glutathione S‐Conjugate Transport Using Inside‐Out Vesicles from Human Erythrocytes

1982 • 93 citations

Two distinct mechanisms for bilirubin glucuronide transport by rat bile canalicular membrane vesicles. Demonstration of defective ATP-dependent transport in rats (TR-) with inherited conjugated hyperbilirubinemia.

1992 • 89 citations

Multidrug resistance protein-mediated transport of chlorambucil and melphalan conjugated to glutathione

1998 • 87 citations

Isolation of a Novel Human Canalicular Multispecific Organic Anion Transporter, cMOAT2/MRP3, and Its Expression in Cisplatin-Resistant Cancer Cells with Decreased ATP-Dependent Drug Transport

1998 • 87 citations

Activity and expression of the multidrug resistance proteins MRP1 and MRP2 in acute myeloid leukemia cells, tumor cell lines, and normal hematopoietic CD34+ peripheral blood cells.

1998 • 87 citations

Temocaprilat, a novel angiotensin-converting enzyme inhibitor, is excreted in bile via an ATP-dependent active transporter (cMOAT) that is deficient in Eisai hyperbilirubinemic mutant rats (EHBR).

1997 • 86 citations

Expression of the apical conjugate export pump, Mrp2, in the polarized hepatoma cell line, WIF-B

1998 • 84 citations

Analysis of the Intron–Exon Organization of the Human Multidrug-Resistance Protein Gene (MRP) and Alternative Splicing of Its mRNA

1997 • 80 citations

Carrier-mediated mechanism for the biliary excretion of the quinolone antibiotic grepafloxacin and its glucuronide in rats.

1998 • 75 citations

Transport of the glutathione conjugate of ethacrynic acid by the human multidrug resistance protein MRP

1996 • 73 citations

Overexpression of multidrug resistance genes MDR1 and cMOAT in human hepatocellular carcinoma and hepatoblastoma cell lines.

1999 • 72 citations

Different Pattern of MRP Localization in Ciliated and Basal Cells from Human Bronchial Epithelium

1998 • 72 citations

A Splice Mutation in the Human Canalicular Multispecific Organic Anion Transporter Gene Causes Dubin-Johnson Syndrome

1998 • 70 citations

Molecular dissection of the human multidrug resistance P-glycoprotein

1999 • 70 citations

Epitope Insertion Favors a Six Transmembrane Domain Model for the Carboxy-Terminal Portion of the Multidrug Resistance-Associated Protein

1998 • 70 citations

The Specific Bisindolylmaleimide PKC-Inhibitor GF 109203X Efficiently Modulates MRP-Associated Multiple Drug Resistance

1995 • 66 citations

ATP‐dependent leukotriene export from mastocytoma cells

1991 • 64 citations

The anthracycline resistance-associated (ara) gene, a novel gene associated with multidrug resistance in a human leukaemia cell line

1996 • 64 citations

ATP stimulates the uptake of S‐dinitrophenylglutathione by rat liver plasma membrane vesicles

1988 • 57 citations

Accumulation of organic anion in intracellular vesicles of cultured rat hepatocytes is mediated by the canalicular multispecific organic anion transporter.

1993 • 54 citations

Kinetic analysis of the primary active transport of conjugated metabolites across the bile canalicular membrane: comparative study of S-(2,4-dinitrophenyl)-glutathione and 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)benzothiazole glucuronide.

1997 • 50 citations

Human Canalicular Multispecific Organic Anion Transporter (cMOAT) Is Expressed in Human Lung, Gastric, and Colorectal Cancer Cells

1997 • 50 citations

X-HUSAR, an X-based graphical interface for the analysis of genomic sequences

1995 • 48 citations

Induction of the multispecific organic anion transporter (cMoat/mrp2) gene and biliary glutathione secretion by the herbicide 2,4,5-trichlorophenoxyacetic acid in the mouse liver

1999 • 43 citations

Human MRP3 transporter: identification of the 5′-flanking region, genomic organization and alternative splice variants1The GenBank accession numbers of MRP3 and its splice variants MRP3A and MRP3B described in this paper are AF085690, AF085691 and AF085692, respectively.1

1999 • 42 citations

Redistribution of canalicular organic anion transport activity in isolated and cultured rat hepatocytes*1

1995 • 42 citations

A multidrug-resistance protein (MRP)-like transmembrane pump is highly expressed by resting murine T helper (Th) 2, but not Th1 cells, and is induced to equal expression levels in Th1 and Th2 cells after antigenic stimulation in vivo.

1998 • 41 citations

Noninvasive assessment of hepatobiliary and renal elimination of cysteinyl leukotrienes by positron emission tomography

1995 • 37 citations

Accumulation of organic anion in intracellular vesicles of cultured rat hepatocytes is mediated by the canalicular multispecific organic anion transporter

1993 • 37 citations

Difloxacin reverses multidrug resistance in HL-60/AR cells that overexpress the multidrug resistance-related protein (MRP) gene.

1995 • 36 citations

Use of the anionic dye carboxy-2',7'-dichlorofluorescein for sensitive flow cytometric detection of multidrug resistance-associated protein activity.

1999 • 34 citations

Inhibitors of MRP1-mediated multidrug resistance

1998 • 29 citations

Evidence for a multidrug resistance-associated protein 1 (MRP1)-related transport system in cultured rat liver biliary epithelial cells

1999 • 29 citations

ATP-stimulated uptake of S-(2,4-dinitrophenyl)glutathione by plasma membrane vesicles from rat liver

1989 • 25 citations

Targeting of aminopeptidase n to bile canaliculi correlates with secretory activities of the developing canalicular domain

1999 • 23 citations

A possible role of inwardly rectifying K+ channels in chick myoblast differentiation

1997 • 23 citations

Hepatobiliary elimination of the peroxisome proliferator nafenopin by conjugation and subsequent atp-dependent transport across the canalicular membrane

1994 • 18 citations

Primary active transport of peptidic endothelin antagonists by rat hepatic canalicular membrane.

1999 • 8 citations