The multidrug resistance and cystic fibrosis genes have complementary patterns of epithelial expression.

The Physiology of Reproduction

1988 • 3,218 citations

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

1989 • 1,744 citations

DEFINITION OF THE STAGES OF THE CYCLE OF THE SEMINIFEROUS EPITHELIUM IN THE RAT

1952 • 1,660 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 • 1,547 citations

Structural model of ATP-binding proteing associated with cystic fibrosis, multidrug resistance and bacterial transport

1990 • 1,149 citations

Demonstration That CFTR Is a Chloride Channel by Alteration of Its Anion Selectivity

1991 • 1,108 citations

Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues.

1990 • 1,063 citations

Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

1986 • 1,058 citations

Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells

1991 • 962 citations

Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR)

1992 • 937 citations

Membrane mechanisms in volume and pH regulation in vertebrate cells

1989 • 880 citations

Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction.

1990 • 736 citations

Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel

1991 • 658 citations

Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein.

1989 • 606 citations

Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein

1992 • 567 citations

Cystic fibrosis: a disease in electrolyte transport

1990 • 510 citations

Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16.

1988 • 443 citations

Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities.

1990 • 420 citations

Immunocytochemical localization of the cystic fibrosis gene product CFTR.

1991 • 419 citations

Detection of P-glycoprotein isoforms by gene-specific monoclonal antibodies.

1990 • 386 citations

Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein

1992 • 328 citations

In vivo cell-specific expression of the cystic fibrosis transmembrane conductance regulator

1991 • 327 citations

The functions of uterine secretions

1988 • 325 citations

Localization of the cystic fibrosis transmembrane conductance regulator in pancreas.

1991 • 296 citations

Sequence of mdr3 cDNA encoding a human P-glycoprotein

1988 • 292 citations

The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus.

1988 • 270 citations

Cloning and characterization of a second member of the mouse mdr gene family.

1988 • 268 citations

Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells

1989 • 241 citations

Activation of chloride channels in normal and cystic fibrosis airway epithelial cells by multifunctional calcium/calmodulin-dependent protein kinase

1991 • 192 citations

Secretin-regulated chloride channel on the apical plasma membrane of pancreatic duct cells

1988 • 186 citations

The cystic fibrosis gene has a “housekeeping”-type promoter and is expressed at low levels in cells of epithelial origin

1991 • 170 citations

Swelling-induced and depolarization-induced C1-channels in normal and cystic fibrosis epithelial cells

1991 • 166 citations

Resistance to multiple chemotherapeutic agents in human cancer cells

1988 • 161 citations

Cloning and characterization of a member of the rat multidrug resistance (mdr) gene family

1991 • 104 citations

Multidrug resistance gene expression is controlled by steroid hormones in the secretory epithelium of the uterus

1990 • 103 citations

Characterization of the promoter region of the cystic fibrosis transmembrane conductance regulator gene.

1991 • 99 citations

Regulation of CFTR expression and function during differentiation of intestinal epithelial cells.

1992 • 75 citations

Sex‐dependent and independent expression of the P‐glycoprotein isoforms in Chinese hamster

1990 • 74 citations

Two Members of the Mouse mdr Gene Family Confer Multidrug Resistance with Overlapping but Distinct Drug Specificities

1990 • 69 citations

Cation and anion transport pathways in volume regulatory response of human lymphocytes to hyposmotic media

1985 • 67 citations

Mammalian multidrug-resistance gene: correlation of exon organization with structural domains and duplication of an ancestral gene.

1989 • 62 citations

Complete cDNA sequences encoding the Chinese hamster P-glycoprotein gene family

1991 • 57 citations

Cloning and Characterization of a Second Member of the Mouse mdr Gene Family

1988 • 45 citations

The tissue dependent expression of hamster P‐glycoprotein genes

1988 • 42 citations

Separate K+ and Cl- transport pathways are activated for regulatory volume decrease in jejunal villus cells

1991 • 28 citations

K+ and Cl‐ currents in enterocytes isolated from guinea‐pig small intestinal villi.

1991 • 27 citations

P-Glycoprotein Content and Mediation of Vincristine Efflux: Correlation with the Level of Differentiation in Luminal Epithelium of Mouse Small Intestine

1991 • 25 citations

Regulatory volume decrease in small intestinal crypts is inhibited by K+ and Cl− channel blockers

1991 • 20 citations

Colonic transepithelial potential difference in infants with cystic fibrosis

1991 • 15 citations

New Insights into the Pathogenesis of Cystic Fibrosis

1990 • 6 citations