The role of mdr1a P-glycoprotein in the biliary and intestinal secretion of doxorubicin and vinblastine in mice.

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

1989 • 1,744 citations

Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

1993 • 1,437 citations

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

1996 • 1,268 citations

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

1995 • 1,109 citations

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

1997 • 934 citations

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

1997 • 871 citations

MDR1 P-Glycoprotein Is a Lipid Translocase of Broad Specificity, While MDR3 P-Glycoprotein Specifically Translocates Phosphatidylcholine

1996 • 863 citations

The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues.

1989 • 467 citations

Substantial excretion of digoxin via the intestinal mucosa and prevention of long‐term digoxin accumulation in the brain by the mdrla P‐glycoprotein

1996 • 278 citations

Altered Pharmacokinetics of Vinblastine in Mdr1a P-glycoprotein-Deficient Mice

1996 • 175 citations

Increased accumulation of doxorubicin and doxorubicinol in cardiac tissue of mice lacking mdr1a P-glycoprotein

1998 • 141 citations

Hepatocyte-specific expression of the humanMDR3P-glycoprotein gene restores the biliary phosphatidylcholine excretion absent inMdr2 (?/?) mice

1998 • 123 citations

Determination of doxorubicin and metabolites in murine specimens by high-performance liquid chromatography

1998 • 75 citations

Interactions between P‐glycoprotein substrates and other cationic drugs at the hepatic excretory level

1998 • 56 citations

Effect of multidrug resistance modulators on the hepatobiliary disposition of doxorubicin in the isolated perfused rat liver.

1998 • 53 citations

In vivo and in vitro pharmacokinetics and metabolism of vincaalkaloids in rat II. Vinblastine and Vincristine

1990 • 40 citations

Disposition of 14C-labelled 4?-epidoxorubicin and doxorubicin in the rat

1984 • 38 citations

Tissue disposition, excretion and metabolism of vinblastine in mice as determined by high-performance liquid chromatography

1993 • 24 citations

Investigation of the enterohepatic recirculation of Adriamycin and its metabolites by a linked-rat model

1998 • 14 citations

New physiological functions for drug-transporting P-glycoproteins?

1998 • 13 citations