Molecular dissection of the human multidrug resistance P-glycoprotein

p53 Mutations in Human Cancers

1991 • 8,133 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

1989 • 1,744 citations

Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.

1981 • 1,463 citations

Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

1993 • 1,437 citations

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

1987 • 1,080 citations

Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

1986 • 1,058 citations

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.

1998 • 1,058 citations

Isolation and expression of a complementary DNA that confers multidrug resistance

1986 • 808 citations

Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance

1999 • 796 citations

Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studies.

1970 • 752 citations

Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance

1986 • 680 citations

Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase.

1992 • 629 citations

Phosphatidylcholine translocase: A physiological role for the mdr2 gene

1994 • 600 citations

Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein

1992 • 567 citations

P-glycoprotein and multidrug resistance

1996 • 549 citations

Fluorescent cellular indicators are extruded by the multidrug resistance protein.

1993 • 496 citations

HIV-1 Protease Inhibitors Are Substrates for theMDR1 Multidrug Transporter

1998 • 480 citations

The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues.

1989 • 467 citations

Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins.

1986 • 461 citations

The physiological function of drug-transporting P-glycoproteins

1997 • 457 citations

The P-Glycoprotein Efflux Pump: How Does it Transport Drugs?

1997 • 449 citations

An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene

1988 • 430 citations

Genetic and biochemical characterization of multidrug resistance

1985 • 405 citations

Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis.

1992 • 395 citations

Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells.

1990 • 386 citations

Circumvention of vincristine and Adriamycin resistance in vitro and in vivo by calcium influx blockers.

1983 • 384 citations

The ABC of channel regulation

1995 • 375 citations

Structure of the Multidrug Resistance P-glycoprotein to 2.5 nm Resolution Determined by Electron Microscopy and Image Analysis

1997 • 341 citations

Hypothesis about the function of membrane-buried proline residues in transport proteins.

1986 • 334 citations

Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein

1992 • 328 citations

Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance.

1989 • 303 citations

The human mdr3 gene encodes a novel P-glycoprotein homologue and gives rise to alternatively spliced mRNAs in liver.

1987 • 283 citations

The human MDR3 P‐glycoprotein promotes translocation of phosphatidylcholine through the plasma membrane of fibroblasts from transgenic mice

1994 • 278 citations

Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins.

1990 • 271 citations

P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans.

1996 • 266 citations

Relationship of the expression of the multidrug resistance gene product (P-glycoprotein) in human colon carcinoma to local tumor aggressiveness and lymph node metastasis.

1991 • 261 citations

Functional reconstitution of drug transport and ATPase activity in proteoliposomes containing partially purified P-glycoprotein.

1993 • 257 citations

Membrane Topology of a Cysteine-less Mutant of Human P-glycoprotein

1995 • 252 citations

ATPase activity of purified and reconstituted P-glycoprotein from Chinese hamster ovary cells.

1994 • 235 citations

Intrinsic drug resistance in human kidney cancer is associated with expression of a human multidrug-resistance gene.

1987 • 225 citations

Correction of Defective Protein Kinesis of Human P-glycoprotein Mutants by Substrates and Modulators

1997 • 224 citations

Characterization of the adenosine triphosphatase activity of Chinese hamster P-glycoprotein.

1993 • 220 citations

Functional consequences of proline mutations in the predicted transmembrane domain of P-glycoprotein.

1993 • 218 citations

Characterization of the azidopine and vinblastine binding site of P-glycoprotein.

1992 • 217 citations

Identification of members of the P-glycoprotein multigene family.

1989 • 195 citations

Major photoaffinity drug labeling sites for iodoaryl azidoprazosin in P-glycoprotein are within, or immediately C-terminal to, transmembrane domains 6 and 12

1993 • 194 citations

The multidrug resistance and cystic fibrosis genes have complementary patterns of epithelial expression.

1992 • 190 citations

Relation Between the Turnover Number for Vinblastine Transport and for Vinblastine-stimulated ATP Hydrolysis by Human P-glycoprotein

1997 • 190 citations

Clinical multidrug resistance in cancer: A multifactorial problem

1996 • 182 citations

Rapid Purification of Human P-glycoprotein Mutants Expressed Transiently in HEK 293 Cells by Nickel-Chelate Chromatography and Characterization of their Drug-stimulated ATPase Activities

1995 • 175 citations

Reconstitution of drug-stimulated ATPase activity following co-expression of each half of human P-glycoprotein as separate polypeptides.

1994 • 174 citations

Genes amplified and overexpressed in human multidrug-resistant cell lines.

1988 • 170 citations

p53-dependent regulation of MDR1 gene expression causes selective resistance to chemotherapeutic agents

1997 • 163 citations

Covalent Modification of Human P-glycoprotein Mutants Containing a Single Cysteine in Either Nucleotide-binding Fold Abolishes Drug-stimulated ATPase Activity

1995 • 159 citations

MDR1 gene expression in solid tumours

1996 • 148 citations

Transmembrane Organization of Mouse P-glycoprotein Determined by Epitope Insertion and Immunofluorescence

1996 • 142 citations

Covalent inhibitors of P-glycoprotein ATPase activity.

1994 • 139 citations

Pharmacological considerations in the modulation of multidrug resistance

1996 • 139 citations

Identification of Residues in the Drug-binding Site of Human P-glycoprotein Using a Thiol-reactive Substrate

1997 • 138 citations

Evidence for an alternate model of human P-glycoprotein structure and biogenesis.

1993 • 138 citations

Physical mapping, amplification, and overexpression of the mouse mdr gene family in multidrug-resistant cells.

1990 • 129 citations

Functional consequences of glycine mutations in the predicted cytoplasmic loops of P-glycoprotein.

1994 • 127 citations

Restoration of daunomycin retention in multidrug-resistant P388 cells by submicromolar concentrations of SDZ PSC 833, a nonimmunosuppressive cyclosporin derivative

1991 • 126 citations

Prolonged association of temperature-sensitive mutants of human P-glycoprotein with calnexin during biogenesis.

1994 • 124 citations

Differential amplification and disproportionate expression of five genes in three multidrug-resistant Chinese hamster lung cell lines.

1986 • 113 citations

Human (MDR1) and Mouse (mdr1,mdr3) P-glycoproteins Can Be Distinguished by Their Respective Drug Resistance Profiles and Sensitivity to Modulators

1995 • 109 citations

Photoaffinity probes for the alpha 1-adrenergic receptor and the calcium channel bind to a common domain in P-glycoprotein.

1990 • 108 citations

Drug-stimulated ATPase Activity of Human P-glycoprotein Requires Movement between Transmembrane Segments 6 and 12

1997 • 100 citations

The multidrug resistance P-glycoprotein modulates cell regulatory volume decrease.

1996 • 89 citations

Localization of the forskolin labeling sites to both halves of P-glycoprotein: similarity of the sites labeled by forskolin and prazosin.

1994 • 89 citations

Membrane Topology of P-Glycoprotein As Determined by Epitope Insertion: Transmembrane Organization of the N-Terminal Domain of mdr3

1995 • 86 citations

Volume-sensitive chloride currents in four epithelial cell lines are not directly correlated to the expression of the MDR-1 gene.

1994 • 79 citations

The role of the MDR protein in altered drug translocation across tumor cell membranes

1995 • 79 citations

D‐verapamil and L‐verapamil are equally effective in increasing vincristine accumulation in leukemic cells in vitro

1988 • 78 citations

Inhibition of Oxidative Cross-linking between Engineered Cysteine Residues at Positions 332 in Predicted Transmembrane Segments (TM) 6 and 975 in Predicted TM12 of Human P-glycoprotein by Drug Substrates

1996 • 76 citations

P-glycoprotein in Adult Hematologic Malignancies

1995 • 67 citations

Search for specific inhibitors of multidrug resistance in cancer

1997 • 59 citations

P-glycoprotein in Adult Solid Tumors: Expression and Prognostic Significance

1995 • 59 citations

Characterization of BcgI, a new kind of restriction-modification system.

1994 • 59 citations

The Minimum Functional Unit of Human P-glycoprotein Appears to be a Monomer

1996 • 55 citations

On the Role of DmpK, an Auxiliary Protein Associated with Multicomponent Phenol Hydroxylase from Pseudomonas sp. Strain CF600

1997 • 53 citations

Volume-sensitive Chloride Channel Activity Does Not Depend on Endogenous P-glycoprotein

1995 • 49 citations

Detection of Oligomeric and Monomeric Forms of P-glycoprotein in Multidrug Resistant Cells

1994 • 49 citations

Altered drug translocation mediated by the MDR protein: Direct, indirect, or both?

1996 • 48 citations

Multidrug Resistance in Pediatric Malignancies

1995 • 47 citations

Chromosomal location of human P-glycoprotein gene sequences

1987 • 43 citations

The tissue dependent expression of hamster P‐glycoprotein genes

1988 • 42 citations

Topological Folding and Proteolysis Profile of P-glycoprotein in Membranes of Multidrug-Resistant Cells: Implications for the Drug-Transport Mechanism

1996 • 40 citations

Proximity of the Nucleotide Binding Domains of the P-glycoprotein Multidrug Transporter to the Membrane Surface: A Resonance Energy Transfer Study

1998 • 36 citations

Mutational Analysis of the Predicted First Transmembrane Segment of Each Homologous Half of Human P-glycoprotein Suggests That They Are Symmetrically Arranged in the Membrane

1996 • 34 citations

Failure of P‐glycoprotein (MDR1) expressed in Xenopus oocytes to produce swelling‐activated chloride channel activity.

1995 • 32 citations

Volume-activated chloride current is not related to P-glycoprotein overexpression.

1994 • 31 citations

Diagnosis and reversal of multidrug resistance in paediatric cancers

1996 • 27 citations

Interaction of rat kidney P-glycoprotein with a urinary component and various drugs including cyclosporin A

1994 • 15 citations

Interaction of P-glycoprotein with a hydrophobic component of rat urine

1992 • 13 citations

Photoaffinity analogs for multidrug resistance-related transporters and their use in identifying chemosensitizers

1999 • 9 citations