Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

Improved tools for biological sequence comparison.

1988 • 11,455 citations

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

1989 • 7,327 citations

Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.

1982 • 5,284 citations

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Progressive sequence alignment as a prerequisitetto correct phylogenetic trees

1987 • 1,899 citations

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

1989 • 1,744 citations

Expression of Multidrug Resistance Gene in Human Cancers

1989 • 1,305 citations

Structural model of ATP-binding proteing associated with cystic fibrosis, multidrug resistance and bacterial transport

1990 • 1,149 citations

The detection and classification of membrane-spanning proteins

1985 • 854 citations

Localization of single copy DNA sequences on G-banded human chromosomes by in situ hybridization

1981 • 836 citations

Isolation and expression of a complementary DNA that confers multidrug resistance

1986 • 808 citations

A family of related ATP-binding subunits coupled to many distinct biological processes in bacteria

1986 • 753 citations

Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction.

1990 • 736 citations

Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance

1986 • 680 citations

Multidrug resistance in a human small cell lung cancer cell line selected in adriamycin.

1987 • 343 citations

Establishment of continuous, clonable cultures of small-cell carcinoma of lung which have amine precursor uptake and decarboxylation cell properties.

1980 • 317 citations

Single cell analysis of daunomycin uptake and efflux in multidrug-resistant and -sensitive KB cells: effects of verapamil and other drugs.

1986 • 312 citations

The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus.

1988 • 270 citations

The amplified H circle of methotrexate-resistant leishmania tarentolae contains a novel P-glycoprotein gene.

1990 • 259 citations

Heavy metal resistance: a new role for P-glycoproteins in Leishmania.

1991 • 231 citations

MDR1 Gene Expression in Lung Cancer

1989 • 182 citations

Localization of the human multiple drug resistance gene, MDR1, to 7q21.1

1987 • 179 citations

P-glycoproteins in pathology: The multidrug resistance gene family in humans

1990 • 173 citations

Non-P-glycoprotein-mediated multidrug resistance in a small cell lung cancer cell line: Evidence for decreased susceptibility to drug-induced DNA damage and reduced levels of topoisomerase II

1992 • 171 citations

Subcellular distribution of daunorubicin in P-glycoprotein-positive and -negative drug-resistant cell lines using laser-assisted confocal microscopy.

1991 • 160 citations

Structure of an mdr-like gene from Arabidopsis thaliana. Evolutionary implications.

1992 • 142 citations

Intracellular distribution and pharmacokinetics of daunorubicin in anthracycline-sensitive and -resistant HL-60 cells.

1989 • 132 citations

Correlation of multidrug resistance with decreased drug accumulation, altered subcellular drug distribution, and increased P-glycoprotein expression in cultured SW-1573 human lung tumor cells

1990 • 122 citations

Effect of calcium antagonists on the chemosensitivity of two multidrug-resistant human tumour cell lines which do not overexpress P-glycoprotein

1989 • 107 citations

Early multidrug resistance, defined by changes in intracellular doxorubicin distribution, independent of P-glycoprotein

1991 • 106 citations

Quantitative Determination of Factors Contributing to Doxorubicin Resistance in Multidrug-Resistant Cells

1989 • 102 citations

Elevated expression of Annexin II (Lipocortin II, p36) in a multidrug resistant small cell lung cancer cell line

1992 • 97 citations

Immunohistochemical detection of multidrug resistance associated P-glycoprotein in tumour and stromal cells of human cancers

1990 • 96 citations

Cytotoxic chemotherapy induces cell differentiation in small-cell lung carcinoma.

1991 • 81 citations

Laser scanning and confocal microscopy of daunorubicin, doxorubicin, and rhodamine 123 in multidrug-resistant cells

1991 • 79 citations

Involvement of Vacuolar H+-Adenosine Triphosphatase Activity in Multidrug Resistance in HL60 Cells

1991 • 72 citations

High-resolution chromosomal localization of the β-gene of the human β-globin gene complex by in situ hybridization

1985 • 68 citations

The 1991 Merck Frosst Award. Multidrug resistance in small cell lung cancer

1992 • 55 citations

Patterns of cross-resistance in a multidrug-resistant small-cell lung carcinoma cell line

1990 • 49 citations

Characterization of the estrogen-responsive domain of avian liver and cloning of double-stranded cDNA derived from estrogen-inducible RNA species.

1979 • 26 citations

Lack of expression of p-glycoprotein in 7 small cell lung cancer cell lines established both from untreated and from treated patients

1993 • 19 citations

Primer‐dependent Amplification of mdr1 mRNA by Polymerase Chain Reaction

1992 • 17 citations

In situ hybridization of two cloned chromosome 7 sequences tightly linked to the cystic fibrosis locus

1988 • 14 citations