P-glycoprotein—A mediator of multidrug resistance in tumour cells

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

1989 • 7,327 citations

Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.

1982 • 5,284 citations

ABC Transporters: From Microorganisms to Man

1992 • 3,956 citations

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

1989 • 1,744 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 • 1,547 citations

Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.

1981 • 1,463 citations

Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

1993 • 1,437 citations

Structural model of ATP-binding proteing associated with cystic fibrosis, multidrug resistance and bacterial transport

1990 • 1,149 citations

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

1995 • 1,109 citations

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

1987 • 1,080 citations

Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues.

1990 • 1,063 citations

Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

1986 • 1,058 citations

Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells

1991 • 962 citations

Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies

1985 • 927 citations

Isolation and expression of a complementary DNA that confers multidrug resistance

1986 • 808 citations

Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studies.

1970 • 752 citations

Active outward transport of daunomycin in resistant ehrlich ascites tumor cells

1973 • 729 citations

Is the multidrug transporter a flippase?

1992 • 720 citations

Reduced permeability in CHO cells as a mechanism of resistance to colchicine

1974 • 695 citations

Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone.

1992 • 677 citations

Human P-glycoprotein transports cyclosporin A and FK506.

1993 • 676 citations

Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors.

1982 • 667 citations

Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel

1991 • 658 citations

Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase.

1992 • 629 citations

Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein.

1989 • 606 citations

Phosphatidylcholine translocase: A physiological role for the mdr2 gene

1994 • 600 citations

Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein

1992 • 567 citations

Fluorescent cellular indicators are extruded by the multidrug resistance protein.

1993 • 496 citations

ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells.

1988 • 480 citations

The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues.

1989 • 467 citations

Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16.

1988 • 443 citations

An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene

1988 • 430 citations

Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities.

1990 • 420 citations

Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis.

1992 • 395 citations

Detection of P-glycoprotein isoforms by gene-specific monoclonal antibodies.

1990 • 386 citations

The ABC of channel regulation

1995 • 375 citations

The multidrug resistance (mdr1) gene product functions as an ATP channel.

1993 • 372 citations

Reversal mechanism of multidrug resistance by verapamil: direct binding of verapamil to P-glycoprotein on specific sites and transport of verapamil outward across the plasma membrane of K562/ADM cells.

1989 • 367 citations

TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective

1993 • 365 citations

P-glycoprotein Is Stably Inhibited by Vanadate-induced Trapping of Nucleotide at a Single Catalytic Site

1995 • 362 citations

Functional involvement of P-glycoprotein in blood-brain barrier.

1992 • 352 citations

Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes [see comments]

1992 • 347 citations

Membrane vesicles from multidrug-resistant human cancer cells contain a specific 150- to 170-kDa protein detected by photoaffinity labeling.

1986 • 342 citations

Purification of the 170- to 180-kilodalton membrane glycoprotein associated with multidrug resistance. 170- to 180-kilodalton membrane glycoprotein is an ATPase.

1988 • 340 citations

Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1).

1992 • 335 citations

Identification of the multidrug resistance-related membrane glycoprotein as an acceptor for calcium channel blockers.

1987 • 333 citations

The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles

1989 • 329 citations

Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein

1992 • 328 citations

Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance.

1989 • 303 citations

Structure and expression of the human MDR (P-glycoprotein) gene family.

1989 • 296 citations

Protein kinase A (PKA) still activates CFTR chloride channel after mutagenesis of all 10 PKA consensus phosphorylation sites

1993 • 296 citations

Sequence of mdr3 cDNA encoding a human P-glycoprotein

1988 • 292 citations

Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes [see comments]

1992 • 290 citations

Vinblastine photoaffinity labeling of a high molecular weight surface membrane glycoprotein specific for multidrug-resistant cells.

1986 • 290 citations

The human mdr3 gene encodes a novel P-glycoprotein homologue and gives rise to alternatively spliced mRNAs in liver.

1987 • 283 citations

Molecular and Cellular Biology of Multidrug Resistance in Tumor Cells

1991 • 281 citations

Intracellular pH and the control of multidrug resistance.

1994 • 273 citations

The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus.

1988 • 270 citations

Cloning and characterization of a second member of the mouse mdr gene family.

1988 • 268 citations

Multidrug Resistance in Cancer

1989 • 258 citations

Functional reconstitution of drug transport and ATPase activity in proteoliposomes containing partially purified P-glycoprotein.

1993 • 257 citations

Increased vinblastine binding to membrane vesicles from multidrug-resistant KB cells.

1986 • 255 citations

Membrane Topology of a Cysteine-less Mutant of Human P-glycoprotein

1995 • 252 citations

Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells

1989 • 241 citations

Phorbol esters induce multidrug resistance in human breast cancer cells.

1988 • 241 citations

Distribution of multi-drug resistance-associated P-glycoprotein in normal and neoplastic human tissues

1990 • 240 citations

ATPase activity of purified and reconstituted P-glycoprotein from Chinese hamster ovary cells.

1994 • 235 citations

Both P-glycoprotein Nucleotide-binding Sites Are Catalytically Active

1995 • 226 citations

Isolation and characterization of DNA sequences amplified in multidrug-resistant hamster cells.

1986 • 226 citations

Characterization of the adenosine triphosphatase activity of Chinese hamster P-glycoprotein.

1993 • 220 citations

Functional Complementation of Yeast ste6 by a Mammalian Multidrug Resistance mdr Gene

1992 • 218 citations

Functional consequences of proline mutations in the predicted transmembrane domain of P-glycoprotein.

1993 • 218 citations

Characterization of the azidopine and vinblastine binding site of P-glycoprotein.

1992 • 217 citations

Characterization of the ATPase activity of P-glycoprotein from multidrug-resistant Chinese hamster ovary cells

1995 • 215 citations

Characterization of the human MDR3 P-glycoprotein and its recognition by P-glycoprotein-specific monoclonal antibodies.

1991 • 212 citations

Most drugs that reverse multidrug resistance also inhibit photoaffinity labeling of P-glycoprotein by a vinblastine analog.

1988 • 211 citations

N-glycosylation and deletion mutants of the human MDR1 P-glycoprotein.

1993 • 209 citations

ATP‐binding properties of P glycoprotein from multidrug‐resistant KB cells

1987 • 207 citations

Characterization of the ATPase Activity of Purified Chinese Hamster P-glycoprotein

1994 • 207 citations

Photoaffinity labeling of the multidrug-resistance-related P-glycoprotein with photoactive analogs of verapamil.

1988 • 205 citations

Protein kinase C phosphorylates P-glycoprotein in multidrug resistant human KB carcinoma cells.

1990 • 200 citations

Phosphorylation of the Mr 170,000 to 180,000 glycoprotein specific to multidrug-resistant tumor cells: effects of verapamil, trifluoperazine, and phorbol esters.

1987 • 198 citations

Two different regions of Phosphoglycoprotein are photoaffinity-labeled by azidopine

1989 • 196 citations

Major photoaffinity drug labeling sites for iodoaryl azidoprazosin in P-glycoprotein are within, or immediately C-terminal to, transmembrane domains 6 and 12

1993 • 194 citations

Multidrug-resistance phenotype in Chinese hamster ovary cells.

1983 • 194 citations

Protein kinase C-mediated phosphorylation of the human multidrug resistance P-glycoprotein regulates cell volume-activated chloride channels.

1995 • 191 citations

A single amino acid substitution strongly modulates the activity and substrate specificity of the mouse mdr1 and mdr3 drug efflux pumps.

1991 • 187 citations

Bovine opsin has more than one signal sequence

1985 • 186 citations

The effects of lipids and detergents on ATPase-active P-glycoprotein

1993 • 186 citations

Insertion of a multispanning membrane protein occurs sequentially and requires only one signal sequence

1988 • 185 citations

Structural model of the nucleotide-binding conserved component of periplasmic permeases.

1991 • 183 citations

P-Glycoprotein gene (MDR1) cDNA from human adrenal: Normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance

1989 • 179 citations

Azidopine noncompetitively interacts with vinblastine and cyclosporin A binding to P-glycoprotein in multidrug resistant cells.

1991 • 178 citations

Characterization of the ATPase activity of the Mr 170,000 to 180,000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells.

1988 • 176 citations

Rapid Purification of Human P-glycoprotein Mutants Expressed Transiently in HEK 293 Cells by Nickel-Chelate Chromatography and Characterization of their Drug-stimulated ATPase Activities

1995 • 175 citations

Reconstitution of drug-stimulated ATPase activity following co-expression of each half of human P-glycoprotein as separate polypeptides.

1994 • 174 citations

Structure-function analysis of the histidine permease and comparison with cystic fibrosis mutations.

1991 • 173 citations

P-glycoproteins in pathology: The multidrug resistance gene family in humans

1990 • 173 citations

Reconstitution of Drug Transport by Purified P-glycoprotein

1995 • 172 citations

Classical and novel forms of multidrug resistance and the physiological functions of P-glycoproteins in mammals

1993 • 171 citations

Uptake and retention of daunomycin by mouse leukemic cells as factors in drug response.

1968 • 171 citations

Characterization of Phosphorylation-defective Mutants of Human P-glycoprotein Expressed in Mammalian Cells

1996 • 169 citations

Tamoxifen blocks chloride channels. A possible mechanism for cataract formation.

1994 • 165 citations

Immunocytochemical localization of P170 at the plasma membrane of multidrug-resistant human cells.

1987 • 156 citations

Identification of specific sites in human P-glycoprotein phosphorylated by protein kinase C.

1993 • 154 citations

Altered Drug-stimulated ATPase Activity in Mutants of the Human Multidrug Resistance Protein

1996 • 154 citations

Tissue distribution of the human MDR3 P-glycoprotein.

1994 • 153 citations

Peptide transport by the multidrug resistance pump.

1992 • 152 citations

ATPase activity of partially purified P-glycoprotein from multidrug-resistant Chinese hamster ovary cells

1992 • 147 citations

Transfection with Protein Kinase Cα Confers Increased Multidrug Resistance to MCF-7 Cells Expressing P-Glycoprotein

1991 • 146 citations

The function of Gp170, the multidrug-resistance gene product, in the brush border of rat intestinal mucosa

1992 • 143 citations

Molecular basis of preferential resistance to colchicine in multidrug-resistant human cells conferred by Gly-185----Val-185 substitution in P-glycoprotein.

1990 • 143 citations

mdr2 encodes P-glycoprotein expressed in the bile canalicular membrane as determined by isoform-specific antibodies.

1992 • 141 citations

Covalent inhibitors of P-glycoprotein ATPase activity.

1994 • 139 citations

Evidence for an alternate model of human P-glycoprotein structure and biogenesis.

1993 • 138 citations

Cytoplasmic Orientation and Two-domain Structure of the Multidrug Transporter, P-glycoprotein, Demonstrated with Sequence-specific Antibodies

1989 • 135 citations

Functional expression of P-glycoproteins in secretory vesicles.

1994 • 134 citations

Study of membrane orientation and glycosylated extracellular loops of mouse P-glycoprotein by in vitro translation.

1991 • 132 citations

Phosphorylation of the multidrug resistance associated glycoprotein

1987 • 131 citations

Lower electrical membrane potential and altered pHi homeostasis in multidrug-resistant (MDR) cells: Further characterization of a series of MDR cell lines expressing different levels of P-glycoprotein

1993 • 131 citations

Traffic ATPases: A Superfamily of Transport Proteins Operating from Escherichia coli to Humans

1992 • 129 citations

Functional consequences of glycine mutations in the predicted cytoplasmic loops of P-glycoprotein.

1994 • 127 citations

Functional consequences of phenylalanine mutations in the predicted transmembrane domain of P-glycoprotein.

1993 • 126 citations

Topology of P-glycoprotein as determined by epitope mapping of MRK-16 monoclonal antibody.

1993 • 125 citations

Stability and covalent modification of P-glycoprotein in multidrug-resistant KB cells

1988 • 125 citations

P-glycoprotein

1995 • 125 citations

Prolonged association of temperature-sensitive mutants of human P-glycoprotein with calnexin during biogenesis.

1994 • 124 citations

P-glycoprotein possesses A 1,4-dihydropyridine-selective drug acceptor site which is alloserically coupled to a vinca-alkaloid-selective binding site

1992 • 121 citations

Mutations to Amino Acids Located in Predicted Transmembrane Segment 6 (TM6) Modulate the Activity and Substrate Specificity of Human P-glycoprotein

1994 • 120 citations

Increased Cytosolic pH in Multidrug-Resistant Human Lung Tumor Cells: Effect of Verapamil

1989 • 120 citations

Expression of the human multidrug transporter in insect cells by a recombinant baculovirus

1990 • 119 citations

Activation of MDR1 (P-glycoprotein) gene expression in human cells by protein kinase C agonists.

1992 • 118 citations

The biology of the P-glycoproteins

1995 • 117 citations

Effects of Lipids on ATPase Activity of Purified Chinese Hamster P-Glycoprotein

1995 • 117 citations

Antiestrogens and steroid hormones: Substrates of the human P-glycoprotein

1994 • 115 citations

Transport properties of P-glycoprotein in plasma membrane vesicles from multidrug-resistant Chinese hamster ovary cells

1992 • 114 citations

Identification of residues in the first cytoplasmic loop of P-glycoprotein involved in the function of chimeric human MDR1-MDR2 transporters.

1992 • 114 citations

STE6, the yeast a-factor transporter

1993 • 114 citations

Domain mapping of the photoaffinity drug-binding sites in P-glycoprotein encoded by mouse mdr1b.

1991 • 113 citations

Regulation by phorbol ester and protein kinase C inhibitors, and by a protein phosphatase inhibitor (okadaic acid), of P-glycoprotein phosphorylation and relationship to drug accumulation in multidrug-resistant human KB cells.

1992 • 111 citations

Human (MDR1) and Mouse (mdr1,mdr3) P-glycoproteins Can Be Distinguished by Their Respective Drug Resistance Profiles and Sensitivity to Modulators

1995 • 109 citations

Analysis of P-glycoprotein phosphorylation in HL60 cells isolated for resistance to vincristine.

1991 • 109 citations

Photoaffinity probes for the alpha 1-adrenergic receptor and the calcium channel bind to a common domain in P-glycoprotein.

1990 • 108 citations

Interaction of the P-glycoprotein Multidrug Transporter with Peptides and Ionophores

1995 • 106 citations

Photoaffinity substrates for P-glycoprotein

1992 • 105 citations

Activity of the multidrug transporter results in alkalinization of the cytosol: measurement of cytosolic pH by microinjection of a pH-sensitive dye.

1990 • 104 citations

Cloning and characterization of a member of the rat multidrug resistance (mdr) gene family

1991 • 104 citations

Kinetic evidence suggesting that the multidrug transporter differentially handles influx and efflux of its substrates.

1994 • 103 citations

Differential transport properties of two mdr gene products are distinguished by progesterone.

1990 • 103 citations

Analysis of the steady-state and initial rate of doxorubicin efflux from a series of multidrug resistant cells expressing different levels of P-glycoprotein

1992 • 102 citations

Functional Evidence That Transmembrane 12 and the Loop between Transmembrane 11 and 12 Form Part of the Drug-binding Domain in P-glycoprotein Encoded by MDR1

1995 • 100 citations

Distinct P-glycoprotein precursors are overproduced in independently isolated drug-resistant cell lines.

1988 • 99 citations

Staurosporine, a potent inhibitor of C-kinase, enhances drug accumulation in multidrug-resistant cells

1990 • 98 citations

Partial Inhibition of Multidrug Resistance by Safingol Is Independent of Modulation of P-glycoprotein Substrate Activities and Correlated with Inhibition of Protein Kinase C

1995 • 98 citations

Characterization of the multidrug resistance protein expressed in cell clones stably transfected with the mouse mdr1 cDNA.

1989 • 97 citations

ATPase activity and ATP/ADP‐induced conformational change in the soluble domain of the bacterial protein translocator HlyB

1993 • 97 citations

Differential modulation of P-glycoprotein transport by protein kinase inhibition

1993 • 93 citations

P‐glycoprotein‐mediated transcellular transport of MDR‐reversing agents

1993 • 92 citations

P‐glycoprotein transports corticosterone and is photoaffinity‐labeled by the steroid

1992 • 92 citations

Functional analysis of P-glycoprotein mutants identifies predicted transmembrane domain 11 as a putative drug binding site

1993 • 91 citations

Interaction of bioactive hydrophobic peptides with the human multidrug transporter

1994 • 90 citations

Localization of the forskolin labeling sites to both halves of P-glycoprotein: similarity of the sites labeled by forskolin and prazosin.

1994 • 89 citations

Multidrug resistance of cancer cells

1996 • 89 citations

Modulation of drug permeability in chinese hamster ovary cells. Possible role for phosphorylation of surface glycoproteins

1977 • 89 citations

Membrane Topology of P-Glycoprotein As Determined by Epitope Insertion: Transmembrane Organization of the N-Terminal Domain of mdr3

1995 • 86 citations

Amino-terminal assembly of human P-glycoprotein at the endoplasmic reticulum is directed by cooperative actions of two internal sequences.

1993 • 86 citations

Enhancement of Mdr2-mediated Phosphatidylcholine Translocation by the Bile Salt Taurocholate

1995 • 85 citations

Modulation of P-glycoprotein phosphorylation and drug transport by sodium butyrate

1992 • 85 citations

Overexpression of the multidrug resistance gene mdr3 in spontaneous and chemically induced mouse hepatocellular carcinomas.

1990 • 85 citations

Simultaneous expression of two P-glycoprotein genes in drug-sensitive Chinese hamster ovary cells.

1987 • 84 citations

Functional expression of human mdr1 in the yeast Saccharomyces cerevisiae.

1992 • 83 citations

Membrane topology of the N-terminal half of the hamster P-glycoprotein molecule

1993 • 82 citations

Drug-stimulated ATPase activity of the human P-glycoprotein

1995 • 80 citations

Direct demonstration of high affinity interactions of immunosuppressant drugs with the drug binding site of the human P-glycoprotein.

1994 • 80 citations

Cloning and regulation of the ratmdr2gene

1993 • 79 citations

Volume-sensitive chloride currents in four epithelial cell lines are not directly correlated to the expression of the MDR-1 gene.

1994 • 79 citations

Expression of the antisense cDNA for protein kinase C alpha attenuates resistance in doxorubicin-resistant MCF-7 breast carcinoma cells.

1993 • 79 citations

Functional Dissection of P-glycoprotein Nucleotide-binding Domains in Chimeric and Mutant Proteins

1995 • 78 citations

Mobile ionophores are a novel class of P‐glycoprotein inhibitors

1994 • 78 citations

Functional analysis of chimeric genes obtained by exchanging homologous domains of the mouse mdr1 and mdr2 genes.

1991 • 77 citations

Cystic fibrosis-type mutational analysis in the ATP-binding cassette transporter signature of human P-glycoprotein MDR1.

1994 • 77 citations

Inhibition of N-linked glycosylation of P-glycoprotein by tunicamycin results in a reduced multidrug resistance phenotype

1995 • 74 citations

Phosphorylation by protein kinase C and cyclic AMP-dependent protein kinase of synthetic peptides derived from the linker region of human P-glycoprotein

1994 • 73 citations

Progesterone regulates the murine multidrug resistance mdr1b gene.

1993 • 73 citations

Investigation of the relationship between altered intracellular pH and multidrug resistance in mammalian cells

1990 • 72 citations

ATP hydrolysis by multidrug-resistance protein from Chinese hamster ovary cells

1995 • 72 citations

Characterization of a membrane-associated protein kinase of multidrug-resistant HL60 cells which phosphorylates P-glycoprotein.

1990 • 72 citations

Changes in intra- or extracellular pH do not mediate P-glycoprotein-dependent multidrug resistance.

1993 • 71 citations

Overexpression and purification of the carboxyl-terminal nucleotide-binding domain from mouse P-glycoprotein. Strategic location of a tryptophan residue.

1994 • 71 citations

P‐glycoprotein epitope mapping. I. Identification of a linear human‐specific epitope in the fourth loop of the P‐glycoprotein extracellular domain by MM4.17 murine monoclonal antibody to human multi‐drug‐resistant cells

1994 • 69 citations

P-glycoprotein. ATP hydrolysis by the N-terminal nucleotide-binding domain.

1992 • 69 citations

Partial Reversal of Multidrug Resistance in Human Breast Cancer Cells by an N-Myristoylated Protein Kinase C-α Pseudosubstrate Peptide

1996 • 68 citations

Interaction of forskolin with the P-glycoprotein multidrug transporter

1991 • 68 citations

Continued expression of vinca alkaloid resistance by CCRF-CEM cells after treatment with tunicamycin or pronase.

1982 • 68 citations

Enhancement of Cellular Accumulation of Cyclosporine by Anti-P-glycoprotein Monoclonal Antibody MRK-16 and Synergistic Modulation of Multidrug Resistance

1993 • 68 citations

Membrane topology of multidrug resistance protein expressed in Escherichia coli. N-terminal domain.

1994 • 67 citations

Using purified P-glycoprotein to understand multidrug resistance

1995 • 67 citations

Low External pH and Osmotic Shock Increase the Expression of Human MDR Protein

1994 • 66 citations

Photoaffinity labeling of P-glycoprotein in multidrug resistant cells with photoactive analogs of colchicine

1989 • 65 citations

Modulation of P-Glycoprotein by Protein Kinase C.alpha. in a Baculovirus Expression System

1994 • 65 citations

Targeted disruption of the mouse mdr1b gene reveals that steroid hormones enhance mdr gene expression.

1993 • 65 citations

Deletion and Insertion Mutants of the Multidrug Transporter

1989 • 63 citations

Effects of phosphorylation of P-glycoprotein on multidrug resistance

1995 • 62 citations

Mutation of Glycine 185 to Valine Alters the ATPase Function of the Human P-glycoprotein Expressed in Sf9 Cells

1995 • 62 citations

Identification of the major phosphorylation domain of murine mdr1b P-glycoprotein. Analysis of the protein kinase A and protein kinase C phosphorylation sites.

1993 • 61 citations

Functional expression of mouse mdr1 in Escherichia coli.

1993 • 60 citations

P-glycoprotein-mediated multidrug resistance in normal and neoplastic hematopoietic cells

1994 • 60 citations

Relationships between rhodamine 123 transport, cell volume, and ion-channel function of P-glycoprotein.

1994 • 59 citations

Complete cDNA sequences encoding the Chinese hamster P-glycoprotein gene family

1991 • 57 citations

Membrane potential differences between adriamycin-sensitive and -resistant cells as measured by flow cytometry

1989 • 57 citations

Dimerization of the P-glycoprotein in membranes

1990 • 57 citations

P-glycoprotein expression is increased in human secretory and gestational endometrium.

1991 • 56 citations

Functional expression of P-glycoprotein encoded by the mouse mdr3 gene in yeast cells.

1993 • 56 citations

Altered plasma membrane ultrastructure in multidrug-resistant cells

1988 • 54 citations

Photoaffinity Labeling of P-Glycoprotein in Multidrug-Resistant Cells

1993 • 53 citations

Constitutive expression of multidrug resistance in human colorectal tumours and cell lines

1993 • 52 citations

Circumvention of P-glycoprotein-mediated Multiple Drug Resistance by Phosphorylation Modulators Is Independent of Protein Kinases

1995 • 50 citations

Transmembrane orientation and topogenesis of the third and fourth membrane-spanning regions of human P-glycoprotein (MDR1).

1994 • 49 citations

Detection of Oligomeric and Monomeric Forms of P-glycoprotein in Multidrug Resistant Cells

1994 • 49 citations

Structurally Distinct MDR Modulators Show Specific Patterns of Reversal Against P-Glycoproteins Bearing Unique Mutations at Serine939/941

1994 • 49 citations

Functional studies of P-glycoprotein in inside-out plasma membrane vesicles derived from murine erythroleukemia cells overexpressing MDR 3. Properties and kinetics of the interaction of vinblastine with P-glycoprotein and evidence for its active mediated transport.

1994 • 49 citations

Characterization and functional reconstitution of the multidrug transporter

1995 • 49 citations

Absence of Cooperativity for MgATP and Verapamil Effects on the ATPase Activity of P-Glycoprotein Containing Membrane Vesicles

1993 • 47 citations

P-glycoprotein and cell volume-activated chloride channels

1995 • 47 citations

Purification and reconstitution of functional human P-glycoprotein

1995 • 47 citations

Heterologous expression systems for P-glycoprotein:E. coli, yeast, and baculovirus

1995 • 46 citations

Allosteric regulation of [3H]vinblastine binding to P-glycoprotein of MCF-7 ADR cells by dexniguldipine

1995 • 45 citations

P-glycoprotein-associated Cl- currents are activated by cell swelling but do not contribute to cell volume regulation.

1994 • 45 citations

Multidrug Resistance Protein (Mdr)-alkaline Phosphatase Hybrids in Escherichia coli Suggest a Major Revision in the Topology of the C-terminal Half of Mdr

1995 • 43 citations

Identification of distinct P-glycoprotein gene sequences in rat

1992 • 42 citations

Involvement of Cytoplasmic Factors Regulating the Membrane Orientation of P-Glycoprotein Sequences

1995 • 41 citations

Staurosporine reduces P-glycoprotein expression and modulates multidrug resistance

1993 • 41 citations

Characteristics of Multidrug Resistance in Human Tumor Cells

1991 • 40 citations

Transfection of mu MDR 1 Inhibits Na+-Independent Cl-/-HCO3 Exchange in Chinese Hamster Ovary Cells

1994 • 40 citations

Novel Cl--Dependent Intracellular pH Regulation in Murine MDR 1 Transfectants and Potential Implications

1994 • 39 citations

Functional role of phosphorylation of the multidrug transporter (P-glycoprotein) by protein kinase C in multidrug-resistant MCF-7 cells.

1994 • 38 citations

Molecular analysis of the multidrug transporter

1994 • 37 citations

Evidence that adriamycin resistance in Chinese hamster lung cells is regulated by phosphorylation of a plasma membrane glycoprotein

1983 • 37 citations

ATP and GTP as alternative energy sources for vinblastine transport by P‐170 in KB‐V1 plasma membrane vesicles

1992 • 36 citations

Staurosporine derivatives reverse multidrug resistance without correlation with their protein kinase inhibitory activities.

1993 • 36 citations

Evidence for daunomycin efflux from multidrug-resistant 2780AD human ovarian carcinoma cells against a concentration gradient

1990 • 36 citations

Cloning, Overexpression, Purification, and Characterization of the Carboxyl-terminal Nucleotide Binding Domain of P-glycoprotein

1995 • 36 citations

Glycosylation of P-glycoprotein in a multidrug-resistant KB cell line, and in the human tissues

1991 • 35 citations

Functionally active homodimer of P-glycoprotein in multidrug-resistant tumor cells

1992 • 35 citations

Functional analysis of chimeric proteins constructed by exchanging homologous domains of two P-glycoproteins conferring distinct drug resistance profiles

1992 • 32 citations

The role of mdr2 P-glycoprotein in biliary lipid secretion. Cross-talk between cancer research and biliary physiology

1995 • 32 citations

Volume-activated chloride current is not related to P-glycoprotein overexpression.

1994 • 31 citations

Isolation of rat pgp3 cDNA: evidence for gender and zonal regulation of expression in the liver

1994 • 31 citations

Phospholipid and ether linked phospholipid content alter with cellular resistance to vinblastine

1985 • 30 citations

Identification of a 170 kDa membrane kinase with increased activity in KB‐V1 multidrug resistant cells

1993 • 30 citations

Diversity of multidrug resistance in mammalian cells.

1994 • 30 citations

Reduced mRNA levels for the multidrug‐resistance genes in cAMP‐dependent protein kinase mutant cell lines

1992 • 29 citations

Preparation and utility of a radioiodinated analogue of daunomycin in the study of multidrug resistance.

1989 • 28 citations

Molecular analysis of the multidrug transporter

1993 • 28 citations

Cooperative P‐glycoprotein mediated daunorubicin transport into DNA‐loaded plasma membrane vesicles

1994 • 28 citations

Bryostatin 1 affects P-glycoprotein phosphorylation but not function in multidrug-resistant human breast cancer cells.

1995 • 26 citations

Introduction: The ABC transporter channel superfamily—an overview

1993 • 25 citations

Drug-Stimulated ATPase Activity of a Deletion Mutant of the Human Multidrug-Resistance Protein (MDR1)

1995 • 22 citations

Expression of the MDR1 Gene in Normal Human Tissues

1991 • 21 citations

Expression of Human P-Glycoprotein in Yeast Cells. Effects of Membrane Component Sterols on the Activity of P-Glycoprotein.

1991 • 20 citations

B9209-005, an azido derivative of the chemosensitizer dexniguldipine-HCl, photolabels P-glycoprotein.

1995 • 19 citations

Overcoming of vinblastine resistance by isoquinolinesulfonamide compounds in adriamycin-resistant leukemia cells.

1992 • 18 citations

Bacterial expression of the linker region of human MDR1 P-glycoprotein and mutational analysis of phosphorylation sites

1995 • 17 citations

Effect of Calphostin C (PKC inhibitor) on daunorubicin resistance in and cells: reversal of drug resistance possibly via P-glycoprotein

1994 • 16 citations

Reversal of vinblastine resistance by a new staurosporine derivative, NA-382, in cells

1992 • 15 citations

Immunohistochemical Analysis of P-Glycoprotein Expression in Normal and Tumor Tissues in Humans

1991 • 14 citations

Development of Multidrug Resistance in Rodent Cell Lines

1991 • 14 citations

Binding of Drugs and ATP by P-Glycoprotein and Transport of Drugs by Vesicles from Human Multidrug-Resistant Cells

1991 • 13 citations

P‐glycoprotein epitope mapping. II. The murine monoclonal antibody MM6.15 to human multidrug‐resistant cells binds with three distinct loops in the MDR1‐P‐glycoprotein extracellular domain

1995 • 13 citations

Reconstitution of purified P-glycoprotein into liposomes

1995 • 11 citations

Effects of tunicamycin on anthracycline resistance in P388 murine leukemia cells

1981 • 11 citations

Human P-glycoprotein as a multi-drug transporter analyzed by using transepithelial transport system.

1994 • 7 citations

Intracellular pH and the control of multidrug resistance

1994 • 6 citations