10 Multidrug resistance in acute myeloid leukaemia

ABC Transporters: From Microorganisms to Man

1992 • 3,956 citations

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

1992 • 3,039 citations

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 • 1,547 citations

Expression of Multidrug Resistance Gene in Human Cancers

1989 • 1,305 citations

Cell Surface P-Glycoprotein Associated with Multidrug Resistance in Mammalian Cell Lines

1983 • 1,001 citations

Pharmacology of drugs that alter multidrug resistance in cancer.

1990 • 970 citations

Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells

1991 • 962 citations

The multidrug transporter, a double-edged sword.

1988 • 763 citations

Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.

1986 • 688 citations

Drug-resistance in multiple myeloma and non-Hodgkin's lymphoma: detection of P-glycoprotein and potential circumvention by addition of verapamil to chemotherapy.

1989 • 565 citations

Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein.

1987 • 538 citations

Overexpression of a M(r) 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance.

1993 • 508 citations

Clinical significance of multidrug resistance P-glycoprotein expression on acute nonlymphoblastic leukemia cells at diagnosis [see comments]

1992 • 507 citations

Immunohistochemical detection of P-glycoprotein: prognostic correlation in soft tissue sarcoma of childhood.

1990 • 462 citations

Verapamil and adriamycin in the treatment of drug-resistant ovarian cancer patients.

1987 • 425 citations

Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells.

1988 • 417 citations

Multidrug resistance (mdr1) gene expression in adult acute leukemias: correlations with treatment outcome and in vitro drug sensitivity

1991 • 407 citations

P-glycoprotein expression in malignant lymphoma and reversal of clinical drug resistance with chemotherapy plus high-dose verapamil.

1991 • 388 citations

MDR1 Gene Expression and Treatment Outcome in Acute Myeloid Leukemia

1991 • 372 citations

In vivo circumvention of P-glycoprotein-mediated multidrug resistance of tumor cells with SDZ PSC 833.

1991 • 364 citations

Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes [see comments]

1992 • 347 citations

Membrane vesicles from multidrug-resistant human cancer cells contain a specific 150- to 170-kDa protein detected by photoaffinity labeling.

1986 • 342 citations

Subpopulations of normal peripheral blood and bone marrow cells express a functional multidrug resistant phenotype [see comments]

1992 • 323 citations

Modulation of multidrug-resistant multiple myeloma by cyclosporin

1992 • 317 citations

Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug resistant lung cancer cell lines

1994 • 315 citations

Alteration of etoposide pharmacokinetics and pharmacodynamics by cyclosporine in a phase I trial to modulate multidrug resistance.

1992 • 298 citations

Control of programmed cell death in normal and leukemic cells: new implications for therapy

1993 • 297 citations

Phase I/II trial of cyclosporine as a chemotherapy-resistance modifier in acute leukemia.

1993 • 284 citations

Glutathione S-transferases: role in alkylating agent resistance and possible target for modulation chemotherapy--a review.

1990 • 259 citations

Potentiation of vincristine and Adriamycin effects in human hemopoietic tumor cell lines by calcium antagonists and calmodulin inhibitors.

1983 • 250 citations

Effects of quinidine and related compounds on cytotoxicity and cellular accumulation of vincristine and adriamycin in drug-resistant tumor cells.

1984 • 231 citations

Clinical significance of P-glycoprotein in multidrug resistance malignancies [editorial] [see comments]

1993 • 231 citations

Multidrug-resistant myeloma: laboratory and clinical effects of verapamil as a chemosensitizer

1991 • 228 citations

The direct activation of human multidrug resistance gene (MDR1) by anticancer agents

1989 • 223 citations

Cytidine Deaminase and the Development of Resistance to Arabinosyl Cytosine

1971 • 222 citations

Cytosine Arabinoside Influx and Nucleoside Transport Sites in Acute Leukemia

1982 • 215 citations

Immunohistochemical detection and quantitation of P-glycoprotein in multiple drug-resistant human myeloma cells: association with level of drug resistance and drug accumulation

1989 • 212 citations

Expression of mdr1 and mdr3 Multidrug-resistance Genes in Human Acute and Chronic Leukemias and Association With Stimulation of Drug Accumulation by Cyclosporine

1990 • 210 citations

High-Dose Oral Tamoxifen, a Potential Multidrug-Resistance-Reversal Agent: Phase I Trial in Combination With Vinblastine

1992 • 209 citations

N-glycosylation and deletion mutants of the human MDR1 P-glycoprotein.

1993 • 209 citations

Multidrug resistance (mdr) genes in human cancer

1991 • 209 citations

Cyclosporins as drug resistance modifiers

1992 • 205 citations

Comparative cellular pharmacology of daunorubicin and idarubicin in human multidrug-resistant leukemia cells

1992 • 185 citations

Increased expression of the multidrug resistance-associated protein gene in relapsed acute leukemia

1995 • 182 citations

Amplification of DNA sequences in human multidrug-resistant KB carcinoma cells.

1985 • 176 citations

Clinical significance of P-glycoprotein in multidrug resistance malignancies [editorial] [see comments]

1993 • 172 citations

Detection of activity of P‐glycoprotein in human tumour samples using rhodamine 123

1992 • 172 citations

Competitive interaction of cyclosporins with the Vinca alkaloid-binding site of P-glycoprotein in multidrug-resistant cells.

1990 • 167 citations

Predominance of functional multidrug resistance (MDR-1) phenotype in CD34+ acute myeloid leukemia cells

1993 • 164 citations

P-glycoprotein expression in plasma-cell myeloma is associated with resistance to VAD

1989 • 162 citations

Relationships among Ara-CTP pools, formation of (Ara-C)DNA, and cytotoxicity of human leukemic cells

1984 • 157 citations

The effect of verapamil on the pharmacokinetics of adriamycin

1986 • 146 citations

Characterization of a mutant mouse lymphoma cell with deficient transport of purine and pyrimidine nucleosides.

1979 • 140 citations

Isolation of genetic suppressor elements, inducing resistance to topoisomerase II-interactive cytotoxic drugs, from human topoisomerase II cDNA.

1993 • 138 citations

Structure of the human MDR3 gene and physical mapping of the human MDR locus.

1991 • 136 citations

Overexpression of the MDRL gene in blast cells from patients with acute myelocytic leukemia is associated with decreased anthracycline accumulation that can be restored by cyclosporin‐A

1990 • 136 citations

Predictive value for treatment outcome in acute myeloid leukemia of cellular daunorubicin accumulation and P-glycoprotein expression simultaneously determined by flow cytometry

1995 • 133 citations

Isolation and characterization of a deoxycytidine kinase-deficient human promyelocytic leukemic cell line highly resistant to 1-beta-D- arabinofuranosylcytosine.

1984 • 127 citations

Expression of the multidrug resistance gene product (P‐glycoprotein) in myelodysplasia is associated with a stem cell phenotype

1991 • 126 citations

Expression of the multidrug resistance gene in myeloid leukemias

1990 • 124 citations

Clinical modulation of doxorubicin resistance by the calmodulin-inhibitor, trifluoperazine: a phase I/II trial.

1988 • 124 citations

Cellular and biochemical characterization of thioxanthenes for reversal of multidrug resistance in human and murine cell lines.

1990 • 123 citations

Activation of MDR1 (P-glycoprotein) gene expression in human cells by protein kinase C agonists.

1992 • 118 citations

Mechanisms of multidrug resistance in HL60 cells: detection of resistance-associated proteins with antibodies against synthetic peptides that correspond to the deduced sequence of P-glycoprotein.

1990 • 116 citations

Membrane transport influences the rate of accumulation of cytosine arabinoside in human leukemia cells.

1987 • 114 citations

High risk of early resistant relapse for leukaemic patients with presence of multidrug resistance associated P‐glycoprotein positive cells in complete remission

1991 • 113 citations

Topoisomerase II levels and drug sensitivity in adult acute myelogenous leukemia

1994 • 113 citations

Effects of 1-beta-D-arabinofuranosylcytosine incorporation on elongation of specific DNA sequences by DNA polymerase beta.

1988 • 108 citations

Feasibility of using quinine, a potential multidrug resistance-reversing agent, in combination with mitoxantrone and cytarabine for the treatment of acute leukemia.

1992 • 108 citations

Deletion of gene for multidrug resistance in acute myeloid leukaemia with inversion in chromosome 16: prognostic implications

1994 • 105 citations

Enhancement of daunorubicin accumulation, retention, and cytotoxicity by verapamil or cyclosporin A in blast cells from patients with previously untreated acute myeloid leukemia

1993 • 105 citations

Clinical trial of continuous infusion verapamil, bolus vinblastine, and continuous infusion VP-16 in drug-resistant pediatric tumors.

1989 • 104 citations

Genetic Mechanisms of Drug Resistance: A Review

1991 • 103 citations

Expression of the multidrug resistance-associated protein (MRP) in acute leukaemia.

1994 • 103 citations

Reversal of drug‐resistance in multiple myeloma with verapamil

1988 • 102 citations

Relevance of mdr1 gene expression in acute myeloid leukemia and comparison of different diagnostic methods.

1992 • 101 citations

Mdr1/P-glycoprotein, topoisomerase, and glutathione-S-transferase π gene expression in primary and relapsed state adult and childhood leukaemias

1992 • 99 citations

Expression of glutathione transferase pi as a predictor for treatment results at different stages of acute nonlymphoblastic leukemia.

1992 • 97 citations

Reversal of drug‐resistance by cyclosporin‐A in a patient with acute myelocytic leukaemia

1990 • 89 citations

Synergistic inhibition by verapamil and quinine of P-glycoprotein- mediated multidrug resistance in a human myeloma cell line model

1991 • 84 citations

Clinical modulation of multidrug resistance in multiple myeloma: effect of cyclosporine on resistant tumor cells.

1994 • 83 citations

Expression of the multidrug resistance associated protein and P- glycoprotein in doxorubicin-selected human myeloid leukemia cells

1994 • 81 citations

Functional multidrug resistance phenotype associated with combined overexpression of Pgp/MDR1 and MRP together with 1-beta-D-arabinofuranosylcytosine sensitivity may predict clinical response in acute myeloid leukemia.

1995 • 79 citations

Synergistic inhibition by verapamil and quinine of P-glycoprotein- mediated multidrug resistance in a human myeloma cell line model

1991 • 76 citations

Increased mdr gene expression and decreased drug accumulation in multidrug-resistant human melanoma cells.

1988 • 75 citations

Daunorubicin uptake by leukemic cells: correlations with treatment outcome and mdr1 expression.

1993 • 75 citations

A pilot study of quinidine and epirubicin in the treatment of advanced breast cancer

1990 • 66 citations

Expression of P-glycoprotein in de novo acute myelogenous leukemia at initial diagnosis: results of molecular and functional assays, and correlation with treatment outcome.

1994 • 63 citations

Expression of MDR1 gene in acute leukemia cells: association with CD7+ acute myeloblastic leukemia/acute lymphoblastic leukemia

1993 • 62 citations

Modulation of multidrug resistance by verapamil or mdr1 anti‐sense oligodeoxynucleotide does not change the high susceptibility to lymphokine‐activated killers in mdr‐resistant human carcinoma (LoVo) line

1990 • 62 citations

Transfection of wild-type deoxycytidine kinase (dck) cDNA into an AraC- and DAC-resistant rat leukemic cell line of clonal origin fully restores drug sensitivity

1995 • 60 citations

A phase I study on the reversal of multidrug resistance (MDR) in vivo: nifedipine plus etoposide

1992 • 60 citations

Multidrug resistant cells with high proliferative capacity determine response to therapy in acute myeloid leukemia.

1995 • 59 citations

Cyclosporin A as a modifier agent in the salvage treatment of acute leukemia (AL).

1993 • 56 citations

Synergistic reversal of multidrug-resistance phenotype in acute myeloid leukemia cells by cyclosporin A and cremophor EL

1994 • 55 citations

Multidrug resistance and its circumvention

1990 • 54 citations

Genetic transfer of non-P-glycoprotein-mediated multidrug resistance (MDR) in somatic cell fusion: dissection of a compound MDR phenotype.

1992 • 49 citations

P-glycoprotein expression and in vitro reversion of doxorubicin resistance by verapamil in clinical specimens from acute leukaemia and myeloma.

1991 • 47 citations

High expression of the multidrug resistance‐associated protein (MRP) in chronic and prolymphocytic leukaemia

1994 • 46 citations

Expression of multidrug resistance gene mdr1 mRNA in a subset of normal bone marrow cells

1992 • 45 citations

P-glycoprotein (P-170) and CD34 expression in adult acute myeloid leukemia (AML).

1994 • 43 citations

Glutathione-s-transferase pi expression in leukaemia: a comparative analysis with mdr-1 data

1990 • 42 citations

Modulation of etoposide (VP-16) cytotoxicity by verapamil or cyclosporine in multidrug-resistant human leukemic cell lines and normal bone marrow.

1990 • 41 citations

Detection of P glycoprotein activity on normal and leukemic CD34+ cells

1993 • 39 citations

High-dose cytosine arabinoside: pharmacological and clinical aspects

1988 • 38 citations

Clinical and pharmacologic study of multidrug resistance reversal with vinblastine and bepridil.

1994 • 37 citations

Correlation of MDR1 /P‐170 expression with daunorubicin uptake and sensitivity of leukemic progenitors in acute myeloid leukemia

1992 • 36 citations

Effects of tumor necrosis factor on sensitive and multidrug resistant human leukemia and myeloma cell lines

1989 • 33 citations

Murine Leukaemia Virus Group-specific Antigen in the C-Type Virus-containing Human Cell Line, ESP-1

1971 • 28 citations

Synergistic interaction of cyclosporin A and verapamil on vincristine and daunorubicin resistance in multidrug-resistant human leukemia cells in vitro

1992 • 25 citations

Resistance to cytosine arabinoside in acute leukemia: the significance of mutations in CTP synthetase.

1994 • 24 citations

In vitro effect of P-glycoprotein (P-gp) modulators on drug sensitivity of leukemic progenitors (CFU-L) in acute myelogenous leukemia (AML).

1992 • 24 citations

A study of the mechanisms of cytotoxicity of Ara-C on three human leukemic cell lines

1989 • 21 citations

The effect of ara-C-induced inhibition of DNA synthesis on its cellular pharmacology

1990 • 17 citations

A difference in sites of DNA synthesis in virus-induced (Shope) and in chemically induced epidermal tumors of rabbit skin.

1967 • 15 citations

Assessment of purging with multidrug resistance (MDR) modulators and VP-16: results of long-term marrow culture.

1990 • 13 citations

Comparative effects of racemic verapamil vs R-verapamil on normal and leukemic progenitors

1993 • 10 citations

Sensitivity of fresh acute myeloid leukemia cells to etoposide: relationship with cell growth characteristics and DNA single-strand breaks

1992 • 8 citations

Influence of cytarabine on mitochondrial function and mitochondrial biogenesis.

1987 • 6 citations