Comparative Analysis of the Th17 Cellular Response in Active and Inactive Pemphigus Vulgaris Patients

NCT04096222

NULLOBSERVATIONAL

Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

42 participants

Started 2021-06-29 · Completed 2023-03-28

Status: Unknown (as of 12-23-2025)

Conditions

Pemphigus VulgarisBullous DermatosesAutoimmune Diseases

Interventions

Linked Papers (from SciSciNet-V2)

Total Papers70

Background

13

Result

0

Derived

0

Unknown

57

View on ClinicalTrials.gov

Total Citations Per Year

Brief Summary

This study will compare the pattern of Th17 immune response in active and inactive pemphigus subjects. Skin and serum samples will be taken at the moment of enrollment.

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Background Papers26

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

1,744 citations

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

1,744 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1,547 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1,547 citations

Consensus statement on definitions of disease, end points, and therapeutic response for pemphigus

Consensus statement on definitions of disease, end points, and therapeutic response for pemphigus

ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells.

ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells.

Th17 Cells Induce Ectopic Lymphoid Follicles in Central Nervous System Tissue Inflammation

Th17 Cells Induce Ectopic Lymphoid Follicles in Central Nervous System Tissue Inflammation

Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids

Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids

Diagnosis and management of pemphigus: Recommendations of an international panel of experts

Diagnosis and management of pemphigus: Recommendations of an international panel of experts

Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism

Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism

A physiologic function for p-glycoprotein (MDR-1) during the migration of dendritic cells from skin via afferent lymphatic vessels

A physiologic function for p-glycoprotein (MDR-1) during the migration of dendritic cells from skin via afferent lymphatic vessels

Management of Pemphigus Vulgaris

Management of Pemphigus Vulgaris

Th1/Th17-Related Cytokines and Chemokines and Their Implications in the Pathogenesis of Pemphigus Vulgaris

Th1/Th17-Related Cytokines and Chemokines and Their Implications in the Pathogenesis of Pemphigus Vulgaris

Ectopic lymphoid neogenesis is strongly associated with activation of the IL-23 pathway in rheumatoid synovitis

Ectopic lymphoid neogenesis is strongly associated with activation of the IL-23 pathway in rheumatoid synovitis

Overexpression of Interleukin-23 and Interleukin-17 in the Lesion of Pemphigus Vulgaris: A Preliminary Study

Overexpression of Interleukin-23 and Interleukin-17 in the Lesion of Pemphigus Vulgaris: A Preliminary Study

Result Papers0

No result papers linked

Derived Papers0

No derived papers linked

Unknown Papers57

ABC Transporters: From Microorganisms to Man

3,956 citations

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

3,515 citations

Foxp3⁺CD25⁺CD4⁺ natural regulatory T cells in dominant self‐tolerance and autoimmune disease

1,535 citations

Mammalian ABC Transporters in Health and Disease

1,531 citations

A brief history of TH17, the first major revision in the TH1/TH2 hypothesis of T cell–mediated tissue damage

1,359 citations

Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues.

1,063 citations

The mdrl gene, responsible for multidrug-resistance, codes for P-glycoprotein

P-glycoprotein expression and function in circulating blood cells from normal volunteers

Multiple physiological functions for multidrug transporter P-glycoprotein?

The Adjuvant Therapy of Pemphigus

High multidrug resistance (P-glycoprotein 170) expression in inflammatory bowel disease patients who fail medical therapy

Impact of Genetic Polymorphisms of ABCB1 (MDR1, P-Glycoprotein) on Drug Disposition and Potential Clinical Implications: Update of the Literature

Tumor Necrosis Factor α and Endothelin-1 Increase P-Glycoprotein Expression and Transport Activity at the Blood-Brain Barrier

Involvement of P-glycoprotein in the transmembrane transport of interleukin-2 (IL-2), IL-4, and interferon-gamma in normal human T lymphocytes

Pemphigus vulgaris: Incidence in Jews of different ethnic groups, according to age, sex, and initial lesion

Expression of Multiple Cytochrome P450 Enzymes and Multidrug Resistance-Associated Transport Proteins in Human Skin Keratinocytes

Rapid Modulation of P-Glycoprotein-Mediated Transport at the Blood-Brain Barrier by Tumor Necrosis Factor-α and Lipopolysaccharide

Patterns of remission in pemphigus vulgaris

Introducing a novel Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) in pemphigus.

Detection of activity of P‐glycoprotein in human tumour samples using rhodamine 123

Autoimmune bullous skin diseases. Part 1: Clinical manifestations

Adjuvant Therapy of Pemphigus

S2k guideline for the diagnosis of pemphigus vulgaris/foliaceus and bullous pemphigoid

Overcoming drug resistance induced by P-glycoprotein on lymphocytes in patients with refractory rheumatoid arthritis

Pivotal Role of Lesional and Perilesional T/B Lymphocytes in Pemphigus Pathogenesis

ABC drug transporters and immunity: novel therapeutic targets in autoimmunity and cancer

Multidrug resistance-1 (MDR-1) in rheumatic autoimmune disorders. Part I: Increased P-glycoprotein activity in lymphocytes from rheumatoid arthritis patients might influence disease outcome.

A role for Th17 cells in the regulation of tertiary lymphoid follicles

Modulators of Multidrug Resistance: Preclinical Studies

EXPRESSION OF THE MULTDORUG RESISTANCE GLYCOPROTEIN 170 IN THE PERIPHERAL BLOOD LYMPHOCYTES OF RHEUMATOID ARTHRITIS PATIENTS. THE PERCENTAGE OF LYMPHOCYTES EXPRESSING GLYCOPROTEIN 170 IS INCREASED IN PATIENTS TREATED WITH PREDNISOLONE

Novel System Evaluating In Vivo Pathogenicity of Desmoglein 3-Reactive T Cell Clones Using Murine Pemphigus Vulgaris

CD4<sup>+</sup>CD25<sup>high</sup> Regulatory T Cells Are Markedly Decreased in Blood of Patients with Pemphigus Vulgaris

Assessment of the rate of long-term complete remission off therapy in patients with pemphigus treated with different regimens including medium- and high-dose corticosteroids

The imbalance of Th17 and regulatory T cells in pemphigus patients

Cytokine networks in Pemphigus vulgaris: An integrated viewpoint

Multidrug resistance-1 (MDR-1) in rheumatic autoimmune disorders. Part II: Increased P-glycoprotein activity in lymphocytes from systemic lupus erythematosus patients might affect steroid requirements for disease control.

Distinctive Treg associated CCR4-CCL22 expression profile with altered frequency of Th17/Treg cell in the immunopathogenesis of Pemphigus Vulgaris

P-glycoprotein in autoimmune rheumatic diseases

Dapsone as a Glucocorticoid-Sparing Agent in Maintenance-Phase Pemphigus Vulgaris

P-Glycoprotein (Abcb1) is involved in absorptive drug transport in skin

Characterization of ABC transporters in human skin

Treatment strategy based on targeting P-glycoprotein on peripheral lymphocytes in patients with systemic autoimmune disease

Evidence of post-translational regulation of P-glycoprotein associated with the expression of a distinctive multiple drug-resistant phenotype in Chinese hamster ovary cells

Aberrant epigenetic modifications in peripheral blood mononuclear cells from patients with pemphigus vulgaris

Constructing immunoprofiles to deconstruct disease complexity in pemphigus

The effect of conventional immunosuppressive therapy on cytokine serum levels in pemphigus vulgaris patients.

Expression of multidrug resistance-1 protein correlates with disease activity rather than the refractoriness to methotrexate therapy in rheumatoid arthritis

Multidrug resistance-1 (MDR-1) in autoimmune disorders IV. P-glycoprotein overfunction in lymphocytes from myasthenia gravis patients

P-Glycoprotein in skin contributes to transdermal absorption of topical corticosteroids

Cytokine Indexes in Pemphigus Vulgaris: Perception of Its Immunpathogenesis and Hopes for Non-Steroidal Treatment.

Multidrug resistance-1 (MDR-1) in autoimmune disorders III: Increased P-glycoprotein activity inlymphocytes from immune thrombocytopenic purpura patients

Serum P-glycoprotein level: a potential biomarker of DMARD failure in patients with rheumatoid arthritis

"Pros and Cons" on How to Measure Multidrug Resistance in Leukemias

Effects of the multidrug resistance-1 gene on drug resistance in primary immune thrombocytopenia

[Epidemiology of bullous pemphigoid in 32 years].

Lack of involvement of P-glycoprotein (P-gp) in pemphigus patients with poor response to steroid therapy