Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo.

1996 • 2,901 citations

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

1989 • 1,744 citations

Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.

1981 • 1,463 citations

Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

1993 • 1,437 citations

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

1996 • 1,268 citations

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

1995 • 1,109 citations

Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

1986 • 1,058 citations

Pharmacology of drugs that alter multidrug resistance in cancer.

1990 • 970 citations

Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells

1991 • 962 citations

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

1997 • 871 citations

Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone.

1992 • 677 citations

Drug excretion mediated by a new prototype of polyspecific transporter

1994 • 637 citations

Drug-resistance in multiple myeloma and non-Hodgkin's lymphoma: detection of P-glycoprotein and potential circumvention by addition of verapamil to chemotherapy.

1989 • 565 citations

GENETIC ANALYSIS OF THE MULTIDRUG TRANSPORTER

1995 • 469 citations

The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues.

1989 • 467 citations

Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities.

1990 • 420 citations

How cancer cells evade chemotherapy: sixteenth Richard and Hinda Rosenthal Foundation Award Lecture.

1993 • 357 citations

P-glycoprotein expression and function in circulating blood cells from normal volunteers

1994 • 350 citations

Subpopulations of normal peripheral blood and bone marrow cells express a functional multidrug resistant phenotype [see comments]

1992 • 323 citations

Nonlinear pharmacokinetics of paclitaxel in mice results from the pharmaceutical vehicle Cremophor EL.

1996 • 304 citations

Substantial excretion of digoxin via the intestinal mucosa and prevention of long‐term digoxin accumulation in the brain by the mdrla P‐glycoprotein

1996 • 278 citations

The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus.

1988 • 270 citations

Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells

1989 • 241 citations

Identification of a sister gene to P-glycoprotein.

1995 • 236 citations

The role of the MDR1 (p-glycoprotein) gene in multidrug resistance in vitro and in vivo

1992 • 183 citations

Rhodamine123 reveals heterogeneity within murine Lin-, Sca-1+ hemopoietic stem cells.

1992 • 160 citations

Physical mapping, amplification, and overexpression of the mouse mdr gene family in multidrug-resistant cells.

1990 • 129 citations

Establishment of human T lymphocyte clones highly cytotoxic for an EBV-transformed B cell line in serum-free medium: isolation of clones that differ in phenotype and specificity.

1982 • 117 citations

What have we learnt thus far from mice with disrupted P-glycoprotein genes?

1996 • 109 citations

Modification of rhodamine staining allows identification of hematopoietic stem cells with preferential short-term or long-term bone marrow-repopulating ability.

1995 • 102 citations

The Three Mouse Multidrug Resistance (mdr) Genes Are Expressed in a Tissue-Specific Manner in Normal Mouse Tissues

1989 • 90 citations

Two Members of the Mouse mdr Gene Family Confer Multidrug Resistance with Overlapping but Distinct Drug Specificities

1990 • 69 citations

The activity of natural cytotoxic cells is augmented by interleukin 2 and interleukin 3.

1983 • 65 citations

Diverse multidrug-resistance-modification agents inhibit cytolytic activity of natural killer cells

1993 • 62 citations

A mechanism for P-glycoprotein action in multidrug resistance: are we there yet?

1994 • 50 citations

Extrusion of the P glycoprotein substrate rhodamine-123 distinguishes CD4 memory T cell subsets that differ in IL-2-driven IL-4 production.

1994 • 44 citations

Heterogeneity in P‐glycoprotein (multidrug resistance) activity among murine peripheral T cells: Correlation with surface phenotype and effector function

1994 • 34 citations

Physical Mapping, Amplification, and Overexpression of the Mouse mdr Gene Family in Multidrug-Resistant Cells

1990 • 26 citations