Biliary Secretion of α-Tocopherol and the Role of the mdr2 P-Glycoprotein in Rats and Mice

ABC Transporters: From Microorganisms to Man

1992 • 3,956 citations

Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

1993 • 1,437 citations

Phosphatidylcholine translocase: A physiological role for the mdr2 gene

1994 • 600 citations

High-performance liquid chromatography of thiols and disulfides: Dinitrophenol derivatives

1987 • 504 citations

Alterations in intracellular thiol homeostasis during the metabolism of menadione by isolated rat hepatocytes

1984 • 411 citations

A mild, rapid, and efficient method of lipid extraction for use in determining vitamin E/lipid ratios

1985 • 389 citations

Reversal mechanism of multidrug resistance by verapamil: direct binding of verapamil to P-glycoprotein on specific sites and transport of verapamil outward across the plasma membrane of K562/ADM cells.

1989 • 367 citations

P-Glycoproteins and Multidrug Resistance

1996 • 305 citations

Preferential incorporation of alpha-tocopherol vs gamma-tocopherol in human lipoproteins

1989 • 301 citations

The human MDR3 P‐glycoprotein promotes translocation of phosphatidylcholine through the plasma membrane of fibroblasts from transgenic mice

1994 • 278 citations

Biokinetics of and discrimination between dietaryRRR‐ andSRR‐α‐tocopherols in the male rat

1987 • 256 citations

Role of Tubulin -SH Groups in Polymerization to Microtubules

1974 • 237 citations

Human α-tocopherol transfer protein: cDNA cloning, expression and chromosomal localization

1995 • 224 citations

Chylomicron remnant cholesteryl esters as the major constituent of very low density lipoproteins in plasma of cholesterol-fed rabbits

1977 • 224 citations

Human plasma phospholipid transfer protein accelerates exchange/transfer of α-tocopherol between lipoproteins and cells

1995 • 182 citations

The role of mdr2 P‐glycoprotein in hepatobiliary lipid transport

1997 • 167 citations

Vitamin E protection against chemical-induced cell injury

1987 • 160 citations

Tissue distribution of the human MDR3 P-glycoprotein.

1994 • 153 citations

mdr2 encodes P-glycoprotein expressed in the bile canalicular membrane as determined by isoform-specific antibodies.

1992 • 141 citations

Mechanism of secretion of biliary lipids: Role of a microtubular system in hepatocellular transport of biliary lipids in the rat

1978 • 137 citations

Functional expression of P-glycoproteins in secretory vesicles.

1994 • 134 citations

Determinants of plasma vitamin E concentrations

1994 • 129 citations

Oxidation of vitamin E: evidence for competing autoxidation and peroxyl radical trapping reactions of the tocopheroxyl radical

1990 • 124 citations

Lipid flow in bile formation

1992 • 106 citations

Induction of multidrug resistance gene expression during cholestasis in rats and nonhuman primates

1993 • 101 citations

Transport and distribution of α-tocopherol in lymph, serum and liver cells in rats

1986 • 98 citations

The effects of colchicine on secretion into bile of bile salts, phospholipids, cholesterol and plasma membrane enzymes: bile salts are secreted unaccompanied by phospholipids and cholesterol

1984 • 97 citations

Reduced hepatic α-tocopherol content after long-term administration of ethanol to rats

1987 • 90 citations

The absorption, storage, and metabolism of α-tocopherol-C14 in the rat and chicken

1963 • 89 citations

Apparent Rates of Glutathione Turnover in Rat Tissues

1993 • 86 citations

Enhancement of Mdr2-mediated Phosphatidylcholine Translocation by the Bile Salt Taurocholate

1995 • 85 citations

Cadmium toxicity and bioantioxidants: Status of vitamin E and ascorbic acid of selected organs in rat

1989 • 46 citations

Reactive oxygen metabolites promote cholesterol crystal formation in model bile: Role of lipid peroxidation

1996 • 40 citations

The role of mdr2 P-glycoprotein in biliary lipid secretion. Cross-talk between cancer research and biliary physiology

1995 • 32 citations

Modification of hepatic vitamin E stores in vivo

1991 • 30 citations

Distribution and metabolism of two orally administered esters of tocopherol.

1971 • 27 citations

Distribution and metabolism of two orally administered esters of tocopherol

1971 • 27 citations

Tauro-β-muricholate preserves choleresis and prevents taurocholate-induced cholestasis in colchicine-treated rat liver

1992 • 22 citations

Colchicine and Vinblastine Prevent the Piperonyl Butoxide-Induced Increase in Rat Biliary Output of α-Tocopherol

1996 • 3 citations