Transition-State Formation in ATPase-Negative Mutants of Human MDR1 Protein

ABC Transporters: From Microorganisms to Man

1992 • 3,956 citations

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

Crystal structure of the ATP-binding subunit of an ABC transporter

1998 • 659 citations

Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase.

1992 • 629 citations

The catalytic cycle of P‐glycoprotein

1995 • 432 citations

P-glycoprotein Is Stably Inhibited by Vanadate-induced Trapping of Nucleotide at a Single Catalytic Site

1995 • 362 citations

Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance.

1989 • 303 citations

ATP-DEPENDENT TRANSPORT SYSTEMS IN BACTERIA AND HUMANS: Relevance to Cystic Fibrosis and Multidrug Resistance

1993 • 290 citations

Both P-glycoprotein Nucleotide-binding Sites Are Catalytically Active

1995 • 226 citations

ATP‐binding properties of P glycoprotein from multidrug‐resistant KB cells

1987 • 207 citations

Altered Drug-stimulated ATPase Activity in Mutants of the Human Multidrug Resistance Protein

1996 • 154 citations

Mutations in Either Nucleotide-Binding Site of P-glycoprotein (Mdr3) Prevent Vanadate Trapping of Nucleotide at Both Sites

1998 • 115 citations

Drug-stimulated Nucleotide Trapping in the Human Multidrug Transporter MDR1

1998 • 85 citations

Modulation of ATP and drug binding by monoclonal antibodies against P‐glycoprotein

1991 • 72 citations

Inhibition of P-Glycoprotein ATPase Activity by Beryllium Fluoride

1997 • 54 citations

Effect of modulators on the ATPase activity and vanadate nucleotide trapping of human P-glycoprotein

1998 • 51 citations

Inhibition of P-Glycoprotein ATPase Activity by Procedures Involving Trapping of Nucleotide in Catalytic Sites

1997 • 31 citations

Photoaffinity labelling of P‐glycoprotein catalytic sites

1997 • 23 citations