Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein

Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.

1982 • 5,284 citations

ABC Transporters: From Microorganisms to Man

1992 • 3,956 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

The P-loop — a common motif in ATP- and GTP-binding proteins

1990 • 2,029 citations

Structural model of ATP-binding proteing associated with cystic fibrosis, multidrug resistance and bacterial transport

1990 • 1,149 citations

Demonstration That CFTR Is a Chloride Channel by Alteration of Its Anion Selectivity

1991 • 1,108 citations

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

1987 • 1,080 citations

Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues.

1990 • 1,063 citations

Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR)

1992 • 937 citations

Membrane mechanisms in volume and pH regulation in vertebrate cells

1989 • 880 citations

NUCLEOSIDE PHOSPHOROTHIOATES

1985 • 830 citations

Isolation and expression of a complementary DNA that confers multidrug resistance

1986 • 808 citations

A family of related ATP-binding subunits coupled to many distinct biological processes in bacteria

1986 • 753 citations

Is the multidrug transporter a flippase?

1992 • 720 citations

Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel

1991 • 658 citations

Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase.

1992 • 629 citations

Human Multidrug-Resistant Cell Lines: Increased mdr 1 Expression Can Precede Gene Amplification

1986 • 604 citations

Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein

1992 • 567 citations

Nucleoside triphosphates are required to open the CFTR chloride channel

1991 • 520 citations

A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells.

1988 • 489 citations

ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells.

1988 • 480 citations

Identification of mutations in regions corresponding to the two putative nucleotide (ATP)-binding folds of the cystic fibrosis gene.

1990 • 433 citations

A cluster of cystic fibrosis mutations in the first nucleotide-binding fold of the cystic fibrosis conductance regulator protein

1990 • 397 citations

Sarcoplasmic reticulum contains adenine nucleotide-activated calcium channels

1985 • 378 citations

Purification of the 170- to 180-kilodalton membrane glycoprotein associated with multidrug resistance. 170- to 180-kilodalton membrane glycoprotein is an ATPase.

1988 • 340 citations

Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance.

1989 • 303 citations

A volume-sensitive chloride conductance in human colonic cell line T84

1989 • 275 citations

Effect of Deleting the R Domain on CFTR-Generated Chloride Channels

1991 • 271 citations

The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus.

1988 • 270 citations

Mutation of lysine-48 to arginine in the yeast RAD3 protein abolishes its ATPase and DNA helicase activities but not the ability to bind ATP.

1988 • 263 citations

Maturation and function of cystic fibrosis transmembrane conductance regulator variants bearing mutations in putative nucleotide-binding domains 1 and 2.

1991 • 245 citations

ATP‐binding properties of P glycoprotein from multidrug‐resistant KB cells

1987 • 207 citations

Interaction of P-N-P and P-C-P analogs of adenosine triphosphate with heavy meromyosin, myosin, and actomyosin

1971 • 183 citations

Swelling-induced and depolarization-induced C1-channels in normal and cystic fibrosis epithelial cells

1991 • 166 citations

Reconstitution of a bacterial periplasmic permease in proteoliposomes and demonstration of ATP hydrolysis concomitant with transport.

1989 • 164 citations

Resistance to multiple chemotherapeutic agents in human cancer cells

1988 • 161 citations

Non-P-glycoprotein mediated mechanism for multidrug resistance precedes P-glycoprotein expression during in vitro selection for doxorubicin resistance in a human lung cancer cell line

1991 • 156 citations

Measurement of the intracellular free calcium concentration in salamander rods

1986 • 153 citations

ATP‐sensitive K+ channels in rat pancreatic beta‐cells: modulation by ATP and Mg2+ ions.

1989 • 152 citations

Effects of glycine and GABA on isolated bipolar cells of the mouse retina.

1990 • 151 citations

Volume-activated chloride channels in HeLa cells are blocked by verapamil and dideoxyforskolin

1993 • 126 citations

Mutations in the nucleotide binding loop of adenylate kinase of Escherichia coli

1988 • 114 citations

Energy coupling to periplasmic binding protein-dependent transport systems: stoichiometry of ATP hydrolysis during transport in vivo.

1989 • 107 citations

Structurally and catalytically important residues in the phosphate binding loop of adenylate kinase of Escherichia coli

1990 • 90 citations

Mechanism of adenylate kinase. 6. Are the essential lysines essential?

1990 • 60 citations

Volume-Regulatory Ion Channels in Epithelial Cells

1989 • 59 citations

Effects of a phosphonic acid analog of adenosine triphosphate on actomyosin systems

1960 • 31 citations

Potassium currents of isolated Necturus enterocytes: a whole‐cell patch‐clamp study.

1991 • 20 citations

Regulatory volume decrease in small intestinal crypts is inhibited by K+ and Cl− channel blockers

1991 • 20 citations

Fast kinetic analysis of drug transport in multidrug resistant cells using a pulsed quench-flow apparatus

1990 • 15 citations

Rat liver mitochondrial ATP synthase. Effects of mutations in the glycine-rich region of a beta subunit peptide on its interaction with adenine nucleotides.

1990 • 15 citations