The multidrug resistance protein family

Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines.

1997 • 889 citations

Congenital Jaundice in Rats with a Mutation in a Multidrug Resistance-Associated Protein Gene

1996 • 827 citations

Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells.

1999 • 663 citations

cDNA Cloning of the Hepatocyte Canalicular Isoform of the Multidrug Resistance Protein, cMrp, Reveals a Novel Conjugate Export Pump Deficient in Hyperbilirubinemic Mutant Rats

1996 • 641 citations

MRP3, an organic anion transporter able to transport anti-cancer drugs

1999 • 639 citations

Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA.

1998 • 621 citations

Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump.

1996 • 569 citations

A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome

1997 • 551 citations

Choroid plexus epithelial expression of MDR 1 P glycoprotein and multidrug resistance-associated protein contribute to the blood–cerebrospinal-fluid drug-permeability barrier

1999 • 529 citations

Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance.

1993 • 517 citations

Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane

1999 • 496 citations

Tissue distribution of the multidrug resistance protein.

1996 • 473 citations

A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation.

1996 • 473 citations

Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2.

1999 • 444 citations

Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein

1997 • 432 citations

Characterization of vincristine transport by the M(r) 190,000 multidrug resistance protein (MRP): evidence for cotransport with reduced glutathione.

1998 • 392 citations

Expression of human MRP6, a homologue of the multidrug resistance protein gene MRP1, in tissues and cancer cells.

1999 • 362 citations

Hereditary Chronic Conjugated Hyperbilirubinemia in Mutant Rats Caused by Defective Hepatic Anion Transport

1985 • 352 citations

Characterization of the Transport Properties of Cloned Rat Multidrug Resistance-associated Protein 3 (MRP3)

1999 • 349 citations

Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database

1996 • 338 citations

Functional Multidrug Resistance Protein (MRP1) Lacking the N-terminal Transmembrane Domain

1998 • 318 citations

Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug resistant lung cancer cell lines

1994 • 315 citations

ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2

1997 • 300 citations

Expression of the conjugate export pump encoded by the mrp2 gene in the apical membrane of kidney proximal tubules.

1997 • 294 citations

Evidence that the multidrug resistance protein (MRP) functions as a co-transporter of glutathione and natural product toxins.

1997 • 277 citations

Hepatic expression of multidrug resistance-associated protein-like proteins maintained in eisai hyperbilirubinemic rats.

1998 • 265 citations

Coordinated Induction of / Pump and γ-Glutamylcysteine Synthetase by Heavy Metals in Human Leukemia Cells

1996 • 264 citations

A canalicular multispecific organic anion transporter (cMOAT) antisense cDNA enhances drug sensitivity in human hepatic cancer cells.

1997 • 249 citations

Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione

1999 • 246 citations

Disruption of the murine MRP (multidrug resistance protein) gene leads to increased sensitivity to etoposide (VP-16) and increased levels of glutathione.

1997 • 241 citations

Membrane topology distinguishes a subfamily of the ATP‐binding cassette (ABC) transporters

1997 • 237 citations

Homologues of the human multidrug resistance genes MRP and MDR contribute to heavy metal resistance in the soil nematode Caenorhabditis elegans.

1996 • 223 citations

cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3)¹

1998 • 214 citations

Membrane Topology and Glycosylation of the Human Multidrug Resistance-associated Protein

1996 • 209 citations

Multidrug Resistance Protein 1 Protects the Oropharyngeal Mucosal Layer and the Testicular Tubules against Drug-induced Damage

1998 • 200 citations

Methotrexate is excreted into the bile by canalicular multispecific organic anion transporter in rats.

1997 • 171 citations

The human multidrug resistance-associated protein functionally complements the yeast cadmium resistance factor 1.

1996 • 170 citations

Expression of multidrug resistance protein-related genes in lung cancer: correlation with drug response.

1999 • 168 citations

Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter.

1998 • 145 citations

Anti‐cancer drugs and glutathione stimulate vanadate‐induced trapping of nucleotide in multidrug resistance‐associated protein (MRP)

1997 • 118 citations

Functional Analysis of a Canalicular Multispecific Organic Anion Transporter Cloned from Rat Liver

1998 • 109 citations

Roles of MRP2 and oatp1 in Hepatocellular Export of Reduced Glutathione

1998 • 92 citations

ATP-dependent Transport of Reduced Glutathione on YCF1, the Yeast Orthologue of Mammalian Multidrug Resistance Associated Proteins

1998 • 72 citations

MRP3, a new ATP-binding cassette protein localized to the canalicular domain of the hepatocyte

1999 • 66 citations

Reduction of expression of the multidrug resistance protein (MRP) in human tumor cells by antisense phosphorothioate oligonucleotides

1996 • 66 citations

The anthracycline resistance-associated (ara) gene, a novel gene associated with multidrug resistance in a human leukaemia cell line

1996 • 64 citations

Microbial multidrug-resistance ABC transporters

1994 • 44 citations

Redistribution of canalicular organic anion transport activity in isolated and cultured rat hepatocytes*1

1995 • 42 citations

cDNA Cloning of a Short Type of Multidrug Resistance Protein Homologue,SMRP,from a Human Lung Cancer Cell Line

1997 • 39 citations

ARA,a Novel ABC Transporter, Is Located at 16p13.1, Is Deleted in inv(16) Leukemias, and Is Shown To Be Expressed in Primitive Hematopoietic Precursors

1998 • 22 citations

Re: Characterization of MOAT-C and MOAT-D, New Members of the MRP/cMOAT Subfamily of Transporter Proteins

1999 • 4 citations

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