Multiple physiological functions for multidrug transporter P-glycoprotein?

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Apoptosis by Death Factor

1997 • 5,038 citations

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues.

1990 • 1,063 citations

Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells

1991 • 962 citations

Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR)

1992 • 937 citations

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

1997 • 934 citations

MDR1 P-Glycoprotein Is a Lipid Translocase of Broad Specificity, While MDR3 P-Glycoprotein Specifically Translocates Phosphatidylcholine

1996 • 863 citations

REGULATION OF CERAMIDE PRODUCTION AND APOPTOSIS

1998 • 804 citations

Is the multidrug transporter a flippase?

1992 • 720 citations

Phosphatidylcholine translocase: A physiological role for the mdr2 gene

1994 • 600 citations

Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein

1992 • 567 citations

Apoptosis induced in Jurkat cells by several agents is preceded by intracellular acidification.

1996 • 488 citations

Granzymes: exogenous porteinases that induce target cell apoptosis

1995 • 403 citations

Cell biological mechanisms of multidrug resistance in tumors.

1994 • 377 citations

The drug efflux protein, P-glycoprotein, additionally protects drug-resistant tumor cells from multiple forms of caspase-dependent apoptosis

1998 • 357 citations

Cancer multidrug resistance

1999 • 356 citations

P-glycoprotein expression and function in circulating blood cells from normal volunteers

1994 • 350 citations

Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein

1992 • 328 citations

Depletion of plasma-membrane sphingomyelin rapidly alters the distribution of cholesterol between plasma membranes and intracellular cholesterol pools in cultured fibroblasts

1988 • 323 citations

P-Glycoprotein Protects Leukemia Cells Against Caspase-Dependent, but not Caspase-Independent, Cell Death

1999 • 308 citations

Up-regulation of Caveolae and Caveolar Constituents in Multidrug-resistant Cancer Cells

1998 • 298 citations

A bacterial antibiotic-resistance gene that complements the human multidrug-resistance P-glycoprotein gene

1998 • 234 citations

A physiologic function for p-glycoprotein (MDR-1) during the migration of dendritic cells from skin via afferent lymphatic vessels

1998 • 232 citations

Involvement of P-glycoprotein in the transmembrane transport of interleukin-2 (IL-2), IL-4, and interferon-gamma in normal human T lymphocytes

1996 • 225 citations

Cross-Resistance of CD95- and Drug-Induced Apoptosis as a Consequence of Deficient Activation of Caspases (ICE/Ced-3 Proteases)

1997 • 198 citations

Transduction of Murine Bone Marrow Cells With an MDR1 Vector Enables Ex Vivo Stem Cell Expansion, but These Expanded Grafts Cause a Myeloproliferative Syndrome in Transplanted Mice

1998 • 197 citations

Protein kinase C-mediated phosphorylation of the human multidrug resistance P-glycoprotein regulates cell volume-activated chloride channels.

1995 • 191 citations

Ceramide in apoptosis—does it really matter?

1998 • 189 citations

Mutant cystic fibrosis transmembrane conductance regulator inhibits acidification and apoptosis in C127 cells: possible relevance to cystic fibrosis.

1996 • 172 citations

Peptide transport by the multidrug resistance pump.

1992 • 152 citations

Human MDR 1 Protein Overexpression Delays the Apoptotic Cascade in Chinese Hamster Ovary Fibroblasts

1997 • 149 citations

Multidrug resistance gene (P-glycoprotein) expression in the human fetus.

1992 • 138 citations

Phosphatidylcholine and Phosphatidylethanolamine Behave as Substrates of the Human MDR1 P-Glycoprotein

1997 • 136 citations

Role of Multidrug Resistance P-glycoproteins in Cholesterol Esterification

1997 • 134 citations

Ex vivo expansion of hematopoietic stem and progenitor cells--robbing Peter to pay Paul? [editorial]

1993 • 129 citations

P-glycoprotein possesses A 1,4-dihydropyridine-selective drug acceptor site which is alloserically coupled to a vinca-alkaloid-selective binding site

1992 • 121 citations

Restoration of TNF-α-induced ceramide generation and apoptosis in resistant human leukemia KG1a cells by the P-glycoprotein blocker PSC833

1998 • 117 citations

Multidrug Resistance (MDR1) P-glycoprotein Enhances Esterification of Plasma Membrane Cholesterol

1999 • 115 citations

Preferential expression and activity of multidrug resistance gene 1 product (P-glycoprotein), a functionally active efflux pump, in human CD8 + T cells: A role in cytotoxic effector function

1992 • 110 citations

Evidence for a role of the multidrug resistance protein (MRP) in the outward translocation of NBD-phospholipids in the erythrocyte membrane

1998 • 96 citations

Monoclonal antibodies against P-glycoprotein, an MDR1 gene product, inhibit interleukin-2 release from PHA-activated lymphocytes.

1996 • 93 citations

Stage-specific distribution of P-glycoprotein in first-trimester and full-term human placenta

1994 • 91 citations

The multidrug resistance P-glycoprotein modulates cell regulatory volume decrease.

1996 • 89 citations

Are altered pHi and membrane potential in hu MDR 1 transfectants sufficient to cause MDR protein-mediated multidrug resistance?

1996 • 84 citations

Proliferation-induced decline of primitive hematopoietic progenitor cell activity is coupled with an increase in apoptosis of ex vivo expanded CD34+ cells.

1998 • 81 citations

The multi‐drug resistance reversal agent SR33557 and modulation of vinca alkaloid binding to P‐glycoprotein by an allosteric interaction

1997 • 81 citations

Diverse multidrug-resistance-modification agents inhibit cytolytic activity of natural killer cells

1993 • 62 citations

The multidrug resistance phenotype confers immunological resistance.

1996 • 61 citations

Intracellular pH and Multidrug Resistance Regulate Complement-mediated Cytotoxicity of Nucleated Human Cells

1999 • 57 citations

Characterization of intracellular pH gradients in human multidrug-resistant tumor cells by means of scanning microspectrofluorometry and dual-emission-ratio probes

1999 • 51 citations

Phosphorylation of P-glycoprotein by PKA and PKC modulates swelling-activated Cl⁻currents

1999 • 48 citations

Protein kinase C phosphorylation disengages human and mouse‐1a P‐glycoproteins from influencing the rate of activation of swelling‐activated chloride currents

1998 • 35 citations