Evidence for the Vectorial Nature of Drug (Substrate)-stimulated ATP Hydrolysis by Human P-glycoprotein

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

A rapid, sensitive, and specific method for the determination of protein in dilute solution

1973 • 2,518 citations

BIOCHEMICAL, CELLULAR, AND PHARMACOLOGICAL ASPECTS OF THE MULTIDRUG TRANSPORTER

1999 • 2,049 citations

Structural model of ATP-binding proteing associated with cystic fibrosis, multidrug resistance and bacterial transport

1990 • 1,149 citations

Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase.

1992 • 629 citations

X-ray Structure of the Magnesium(II)·ADP·Vanadate Complex of the Dictyostelium discoideum Myosin Motor Domain to 1.9 Å Resolution^,

1996 • 479 citations

The catalytic cycle of P‐glycoprotein

1995 • 432 citations

Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis.

1992 • 395 citations

P-glycoprotein Is Stably Inhibited by Vanadate-induced Trapping of Nucleotide at a Single Catalytic Site

1995 • 362 citations

Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

1997 • 326 citations

Functional reconstitution of drug transport and ATPase activity in proteoliposomes containing partially purified P-glycoprotein.

1993 • 257 citations

Human P-Glycoprotein Exhibits Reduced Affinity for Substrates during a Catalytic Transition State

1998 • 247 citations

Both P-glycoprotein Nucleotide-binding Sites Are Catalytically Active

1995 • 226 citations

Characterization of the adenosine triphosphatase activity of Chinese hamster P-glycoprotein.

1993 • 220 citations

Characterization of the ATPase activity of P-glycoprotein from multidrug-resistant Chinese hamster ovary cells

1995 • 215 citations

Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoprotein

2000 • 210 citations

Characterization of the ATPase Activity of Purified Chinese Hamster P-glycoprotein

1994 • 207 citations

Relation Between the Turnover Number for Vinblastine Transport and for Vinblastine-stimulated ATP Hydrolysis by Human P-glycoprotein

1997 • 190 citations

Rapid Purification of Human P-glycoprotein Mutants Expressed Transiently in HEK 293 Cells by Nickel-Chelate Chromatography and Characterization of their Drug-stimulated ATPase Activities

1995 • 175 citations

Competitive, non-competitive and cooperative interactions between substrates of P-glycoprotein as measured by its ATPase activity.

1997 • 161 citations

Characterization of the Catalytic Cycle of ATP Hydrolysis by Human P-glycoprotein

2001 • 151 citations

Covalent inhibitors of P-glycoprotein ATPase activity.

1994 • 139 citations

ATP hydrolysis cycles and mechanism inP-glycoprotein and CFTR

1997 • 130 citations

Reaction mechanism of calcium-ATPase of sarcoplasmic reticulum. Substrates for phosphorylation reaction and back reaction, and further resolution of phosphorylated intermediates.

1980 • 129 citations

Mechanism of Action of Human P-glycoprotein ATPase Activity

1998 • 118 citations

Correlation between Steady-state ATP Hydrolysis and Vanadate-induced ADP Trapping in Human P-glycoprotein

2001 • 102 citations

Vanadate-Induced Trapping of Nucleotides by Purified Maltose Transport Complex Requires ATP Hydrolysis

2000 • 97 citations

Stoichiometry of coupling of rhodamine 123 transport to ATP hydrolysis by P‐glycoprotein

1998 • 89 citations

Drug-stimulated Nucleotide Trapping in the Human Multidrug Transporter MDR1

1998 • 85 citations

Inhibition of P-Glycoprotein ATPase Activity by Beryllium Fluoride

1997 • 54 citations

Effect of modulators on the ATPase activity and vanadate nucleotide trapping of human P-glycoprotein

1998 • 51 citations

Conformational Changes in Four Regions of the Escherichia coli ArsA ATPase Link ATP Hydrolysis to Ion Translocation

2001 • 45 citations

Functionally Similar Vanadate-induced 8-Azidoadenosine 5′-[α-32P]Diphosphate-trapped Transition State Intermediates of Human P-glycoprotein Are Generated in the Absence and Presence of ATP Hydrolysis

2001 • 30 citations

ON THE MECHANISM OF ENERGY RELEASE, TRANSFER, AND UTILIZATION IN Na, K‐ATPase TRANSPORT WORK: OLD IDEAS AND NEW FINDINGS

1982 • 26 citations

GTP-Stimulated Phosphorylation of P-Glycoprotein in Transporting Vesicles from KB-V1 Multidrug Resistant Cells

1994 • 21 citations