Positively Cooperative Sites for Drug Transport by P‐Glycoprotein with Distinct Drug Specificities

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

1992 • 3,039 citations

Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

1993 • 1,437 citations

Phosphatidylcholine translocase: A physiological role for the mdr2 gene

1994 • 600 citations

Multidrug Resistance Protein (MRP)-mediated Transport of Leukotriene C4 and Chemotherapeutic Agents in Membrane Vesicles

1996 • 555 citations

P-glycoprotein—A mediator of multidrug resistance in tumour cells

1996 • 406 citations

Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators

1993 • 365 citations

Identification of the multidrug resistance-related membrane glycoprotein as an acceptor for calcium channel blockers.

1987 • 333 citations

Anticancer Drugs, Ionophoric Peptides, and Steroids as Substrates of the Yeast Multidrug Transporter Pdr5p

1996 • 314 citations

Multidrug resistance mediated by a bacterial homolog of the human multidrug transporter MDR1.

1996 • 275 citations

Quercetin potentiates the effect of adriamycin in a multidrug-resistant MCF-7 human breast-cancer cell line: P-glycoprotein as a possible target

1994 • 263 citations

Functional reconstitution of drug transport and ATPase activity in proteoliposomes containing partially purified P-glycoprotein.

1993 • 257 citations

ATPase activity of purified and reconstituted P-glycoprotein from Chinese hamster ovary cells.

1994 • 235 citations

Characterization of the azidopine and vinblastine binding site of P-glycoprotein.

1992 • 217 citations

Characterization of the ATPase Activity of Purified Chinese Hamster P-glycoprotein

1994 • 207 citations

Major photoaffinity drug labeling sites for iodoaryl azidoprazosin in P-glycoprotein are within, or immediately C-terminal to, transmembrane domains 6 and 12

1993 • 194 citations

Effect of quercetin on hoechst 33342 transport by purified and reconstituted p-glycoprotein

1997 • 193 citations

Azidopine noncompetitively interacts with vinblastine and cyclosporin A binding to P-glycoprotein in multidrug resistant cells.

1991 • 178 citations

Reconstitution of Drug Transport by Purified P-glycoprotein

1995 • 172 citations

Modulation of adriamycin® accumulation and efflux by flavonoids in HCT-15 colon cells

1994 • 171 citations

Reconstitution of ATP-dependent Leukotriene C4 Transport by Co-expression of Both Half-molecules of Human Multidrug Resistance Protein in Insect Cells

1996 • 162 citations

A new mammalian DNA topoisomerase I poison Hoechst 33342: cytotoxicity and drug resistance in human cell cultures.

1993 • 148 citations

P‐Glycoprotein‐Mediated Hoechst 33342 Transport Out of the Lipid Bilayer

1997 • 138 citations

Competitive and Non‐Competitive Inhibition of the Multidrug‐Resistance‐Associated P‐glycoprotein ATPase

1997 • 134 citations

Co-operative, competitive and non-competitive interactions between modulators of P-glycoprotein

1996 • 130 citations

Effects of steroids and verapamil on P-glycoprotein ATPase activity: progesterone, desoxycorticosterone, corticosterone and verapamil are mutually non-exclusive modulators

1996 • 120 citations

Transmembrane Aromatic Amino Acid Distribution in P-glycoprotein

1994 • 116 citations

Domain mapping of the photoaffinity drug-binding sites in P-glycoprotein encoded by mouse mdr1b.

1991 • 113 citations

Synthetic hydrophobic peptides are substrates for P-glycoprotein and stimulate drug transport

1996 • 108 citations

Flavonol-stimulated efflux of 7,12-dimethylbenz(a)anthracene in multidrug-resistant breast cancer cells.

1993 • 106 citations

Localization of the forskolin labeling sites to both halves of P-glycoprotein: similarity of the sites labeled by forskolin and prazosin.

1994 • 89 citations

The multidrug‐resistance‐reverser verapamil interferes with cellular P‐glycoprotein‐mediated pumping of daunorubicin as a non‐competing substrate

1994 • 82 citations

Allosteric regulation of [3H]vinblastine binding to P-glycoprotein of MCF-7 ADR cells by dexniguldipine

1995 • 45 citations

Mutually co-operative interactions between modulators of P-glycoprotein

1997 • 41 citations

Non-competitive inhibition of P-glycoprotein-associated efflux of THP-adrimycin by verapamil in living K562 leukemia cells

1994 • 40 citations

The multidrug transporters—proteins of an ancient immune system

1996 • 33 citations

Dexniguldipine-HCl is a potent allosteric inhibitor of [3H]vinblastine binding to P-glycoprotein of CCRF ADR 5000 cells

1994 • 31 citations

Cooperative P‐glycoprotein mediated daunorubicin transport into DNA‐loaded plasma membrane vesicles

1994 • 28 citations

N-(p-azido-3-[125I]iodophenethyl)spiperone binds to specific regions of P-glycoprotein and another multidrug binding protein, spiperophilin, in human neuroblastoma cells

1994 • 27 citations

Competitive inhibition of photoaffinity labelling of P-glycoprotein by anticancer drugs and modulators including S9788

1996 • 9 citations

Reversal of Multidrug Resistance by Valinomycin is Overcome by CCCP

1996 • 8 citations