The Structure of the Multidrug Resistance Protein 1 (MRP1/ABCC1)

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

1992 • 3,039 citations

Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy

1990 • 2,969 citations

SPIDER and WEB: Processing and Visualization of Images in 3D Electron Microscopy and Related Fields

1996 • 2,073 citations

BIOCHEMICAL, CELLULAR, AND PHARMACOLOGICAL ASPECTS OF THE MULTIDRUG TRANSPORTER

1999 • 2,049 citations

Three-Dimensional Electron Microscopy of Macromolecular Assemblies

2006 • 1,113 citations

The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.

1994 • 850 citations

Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells.

1994 • 777 citations

MRC Image Processing Programs

1996 • 718 citations

Structure of purple membrane from halobacterium halobium: recording, measurement and evaluation of electron micrographs at 3.5 Å resolution

1986 • 687 citations

The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump.

1994 • 685 citations

Crystal structure of the ATP-binding subunit of an ABC transporter

1998 • 659 citations

The multidrug resistance protein family

1999 • 654 citations

CYSTIC FIBROSIS: GENOTYPIC AND PHENOTYPIC VARIATIONS

1995 • 613 citations

ABC-ATPases, adaptable energy generators fuelling transmembrane movement of a variety of molecules in organisms from bacteria to humans

1999 • 575 citations

Multidrug Resistance Protein (MRP)-mediated Transport of Leukotriene C4 and Chemotherapeutic Agents in Membrane Vesicles

1996 • 555 citations

Three-dimensional reconstruction of single particles embedded in ice

1992 • 463 citations

The P-Glycoprotein Efflux Pump: How Does it Transport Drugs?

1997 • 449 citations

Structural, mechanistic and clinical aspects of MRP1

1999 • 408 citations

The ribosome at improved resolution: New techniques for merging and orientation refinement in 3D cryo-electron microscopy of biological particles

1994 • 407 citations

Characterization of vincristine transport by the M(r) 190,000 multidrug resistance protein (MRP): evidence for cotransport with reduced glutathione.

1998 • 392 citations

Structure of trypanothione reductase from Crithidia fasciculata at 2.6 Å resolution; enzyme–NADP interactions at 2.8 Å resolution

1994 • 358 citations

Structure of the Multidrug Resistance P-glycoprotein to 2.5 nm Resolution Determined by Electron Microscopy and Image Analysis

1997 • 341 citations

Three-Dimensional Electron Microscopy of Macromolecular Assemblies

1996 • 340 citations

Expression of the Gene for Multidrug-Resistance–Associated Protein and Outcome in Patients with Neuroblastoma

1996 • 321 citations

Functional Multidrug Resistance Protein (MRP1) Lacking the N-terminal Transmembrane Domain

1998 • 318 citations

Accessory Protein Facilitated CFTR-CFTR Interaction, a Molecular Mechanism to Potentiate the Chloride Channel Activity

2000 • 306 citations

ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump

1996 • 290 citations

ATP‐ and glutathione‐dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1

1999 • 256 citations

Membrane Topology of the Multidrug Resistance Protein (MRP)

1997 • 215 citations

Membrane Topology and Glycosylation of the Human Multidrug Resistance-associated Protein

1996 • 209 citations

Comparison of the Functional Characteristics of the Nucleotide Binding Domains of Multidrug Resistance Protein 1

2000 • 175 citations

Expression of the multidrug resistance-associated protein (MRP) gene in human cancers.

1995 • 174 citations

Structural analysis of cloned plasma membrane proteins by freeze-fracture electron microscopy

1998 • 170 citations

Analysis of Electron Microscope Images and Electron Diffraction Patterns of Thin Crystals of Ø29 Connectors in Ice

1994 • 162 citations

Allosteric Interactions between the Two Non-equivalent Nucleotide Binding Domains of Multidrug Resistance Protein MRP1

2000 • 140 citations

Stoichiometry of recombinant cystic fibrosis transmembrane conductance regulator in epithelial cells and its functional reconstitution into cells in vitro.

1994 • 122 citations

The ABCs of ATP-sensitive potassium channels: more pieces of the puzzle

1997 • 113 citations

Structure and expression of the messenger RNA encoding the murine multidrug resistance protein, an ATP-binding cassette transporter.

1996 • 108 citations

Structure of the multidrug resistance P-glycoprotein

1997 • 107 citations

Location of a protease-hypersensitive region in the multidrug resistance protein (MRP) by mapping of the epitope of MRP-specific monoclonal antibody QCRL-1.

1996 • 106 citations

Multidrug resistance protein (MRP) expression in retinoblastoma correlates with the rare failure of chemotherapy despite cyclosporine for reversal of P-glycoprotein.

1997 • 102 citations

Nonequivalent Nucleotide Trapping in the Two Nucleotide Binding Folds of the Human Multidrug Resistance Protein MRP1

2000 • 96 citations

Functional Reconstitution of Substrate Transport by Purified Multidrug Resistance Protein MRP1 (ABCC1) in Phospholipid Vesicles

2000 • 95 citations

ATPase activity of purified and reconstituted multidrug resistance protein MRP1 from drug-selected H69AR cells

1999 • 94 citations

Electron Crystallography of Two-Dimensional Crystals of Membrane Proteins

1998 • 85 citations

Multidrug Resistance Protein

1998 • 80 citations

Monoclonal Antibodies That Inhibit the Transport Function of the 190-kDa Multidrug Resistance Protein, MRP

1999 • 77 citations

A Single Conductance Pore for Chloride Ions Formed by Two Cystic Fibrosis Transmembrane Conductance Regulator Molecules

1999 • 72 citations

Epitope Insertion Favors a Six Transmembrane Domain Model for the Carboxy-Terminal Portion of the Multidrug Resistance-Associated Protein

1998 • 70 citations

Immunohistochemical detection of DNA topoisomerase IIα, P-glycoprotein and multidrug resistance protein (MRP) in small-cell and non-small-cell lung cancer

1998 • 59 citations

Multidrug Resistance Protein MRP1 Reconstituted into Lipid Vesicles: Secondary Structure and Nucleotide-Induced Tertiary Structure Changes

2000 • 32 citations

Radiation Inactivation Suggests That Human Multidrug Resistance-Associated Protein 1 Occurs as a Dimer in the Human Erythrocyte Membrane

1998 • 25 citations

Rebinding of the extrinsic proteins of Photosystem II studied by electron microscopy and single particle alignment: an assessment with small two-dimensional ordered arrays of Photosystem II

1997 • 9 citations