Lysophospholipid receptors: Signalling, pharmacology and regulation by lysophospholipid metabolism

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

2004 • 2,462 citations

Sphingosine-1-phosphate: an enigmatic signalling lipid

2003 • 2,022 citations

Thiazolidinediones

2004 • 1,755 citations

Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists

2002 • 1,655 citations

The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors

2002 • 1,478 citations

Biologically active sphingolipids in cancer pathogenesis and treatment

2004 • 1,191 citations

The emerging role of lysophosphatidic acid in cancer

2003 • 1,086 citations

Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1

1998 • 1,003 citations

Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production

2002 • 908 citations

Minireview: Lipid Metabolism, Metabolic Diseases, and Peroxisome Proliferator-Activated Receptors

2003 • 864 citations

Lymphocyte Sequestration Through S1P Lyase Inhibition and Disruption of S1P Gradients

2005 • 772 citations

Lysophospholipid Receptors: Signaling and Biology

2004 • 752 citations

Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex.

1996 • 727 citations

Identification of Human Plasma Lysophospholipase D, a Lysophosphatidic Acid-producing Enzyme, as Autotaxin, a Multifunctional Phosphodiesterase

2002 • 723 citations

Essential Role for Sphingosine Kinases in Neural and Vascular Development

2005 • 719 citations

Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network

2005 • 681 citations

Proton-sensing G-protein-coupled receptors

2003 • 667 citations

Molecular Cloning and Functional Characterization of a Novel Mammalian Sphingosine Kinase Type 2 Isoform

2000 • 654 citations

Sphingosine 1-Phosphate (S1P) Receptor Subtypes S1P1 and S1P3, Respectively, Regulate Lymphocyte Recirculation and Heart Rate

2004 • 619 citations

HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3

2004 • 611 citations

SphK1 and SphK2, Sphingosine Kinase Isoenzymes with Opposing Functions in Sphingolipid Metabolism

2005 • 606 citations

Discovery and evaluation of inhibitors of human sphingosine kinase.

2003 • 586 citations

Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine -1-phosphate therapy

2000 • 581 citations

HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3

2004 • 578 citations

Identification of p2y9/GPR23 as a Novel G Protein-coupled Receptor for Lysophosphatidic Acid, Structurally Distant from the Edg Family

2003 • 553 citations

The ins and outs of lysophosphatidic acid signaling

2004 • 550 citations

Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARγ agonist

2002 • 545 citations

LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing

2005 • 541 citations

The immunosuppressant FTY720 down‐regulates sphingosine 1‐phosphate G protein‐coupled receptors

2004 • 532 citations

Molecular Cloning and Functional Characterization of Murine Sphingosine Kinase

1998 • 528 citations

Autotaxin, a Secreted Lysophospholipase D, Is Essential for Blood Vessel Formation during Development

2006 • 524 citations

Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation

2003 • 523 citations

Sphingosine Kinase Expression Increases Intracellular Sphingosine-1-Phosphate and Promotes Cell Growth and Survival

1999 • 516 citations

Enzymes of Sphingolipid Metabolism: From Modular to Integrative Signaling

2001 • 496 citations

An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors.

1990 • 474 citations

Stops and starts in mammalian oocytes: recent advances in understanding the regulation of meiotic arrest and oocyte maturation

2005 • 473 citations

Requirement for the lp _A1 lysophosphatidic acid receptor gene in normal suckling behavior

2000 • 468 citations

GPR92 as a New G12/13- and Gq-coupled Lysophosphatidic Acid Receptor That Increases cAMP, LPA5

2006 • 462 citations

FTY720: Sphingosine 1-Phosphate Receptor-1 in the Control of Lymphocyte Egress and Endothelial Barrier Function

2004 • 462 citations

International Union of Pharmacology. XXXIV. Lysophospholipid Receptor Nomenclature

2002 • 462 citations

Autotaxin Stabilizes Blood Vessels and Is Required for Embryonic Vasculature by Producing Lysophosphatidic Acid

2006 • 451 citations

Structural and functional characteristics of S1P receptors

2004 • 450 citations

Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages

2006 • 443 citations

Mice Deficient in Sphingosine Kinase 1 Are Rendered Lymphopenic by FTY720

2004 • 439 citations

Phosphorylation of the Immunomodulatory Drug FTY720 by Sphingosine Kinases

2003 • 427 citations

Role of the Sphingosine-1-Phosphate Receptor EDG-1 in PDGF-Induced Cell Motility

2001 • 421 citations

Sphingosine Kinase 2 Is a Nuclear Protein and Inhibits DNA Synthesis

2003 • 407 citations

Historical review: A brief history and personal retrospective of seven-transmembrane receptors

2004 • 403 citations

Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo

2006 • 400 citations

An oncogenic role of sphingosine kinase

2000 • 394 citations

Ki16425, a Subtype-Selective Antagonist for EDG-Family Lysophosphatidic Acid Receptors

2003 • 392 citations

Phosphorylation and Action of the Immunomodulator FTY720 Inhibits Vascular Endothelial Cell Growth Factor-induced Vascular Permeability

2003 • 375 citations

Sphingosine Kinase Type 2 Is a Putative BH3-only Protein That Induces Apoptosis

2003 • 352 citations

Immune Cell Regulation and Cardiovascular Effects of Sphingosine 1-Phosphate Receptor Agonists in Rodents Are Mediated via Distinct Receptor Subtypes

2004 • 329 citations

Lysophosphatidylcholine as a Ligand for the Immunoregulatory Receptor G2A

2001 • 329 citations

Edg8/S1P5: An Oligodendroglial Receptor with Dual Function on Process Retraction and Cell Survival

2005 • 325 citations

Characterization of a Novel Sphingosine 1-Phosphate Receptor, Edg-8

2000 • 323 citations

Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit

2005 • 318 citations

Characterization of lpa₂ (Edg4) and lpa₁/lpa₂ (Edg2/Edg4) Lysophosphatidic Acid Receptor Knockout Mice: Signaling Deficits without Obvious Phenotypic Abnormality Attributable to lpa₂

2002 • 315 citations

The ins and outs of sphingolipid synthesis

2005 • 314 citations

The G _s -Linked Receptor GPR3 Maintains Meiotic Arrest in Mammalian Oocytes

2004 • 314 citations

PKC-dependent Activation of Sphingosine Kinase 1 and Translocation to the Plasma Membrane

2002 • 293 citations

Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1

2000 • 291 citations

Antagonism of Sphingosine-1-Phosphate Receptors by FTY720 Inhibits Angiogenesis and Tumor Vascularization

2006 • 288 citations

Lysophospholipid G Protein-coupled Receptors

2004 • 281 citations

Extracellular Export of Sphingosine Kinase-1 Enzyme

2002 • 281 citations

EDG1 Is a Functional Sphingosine-1-phosphate Receptor That Is Linked via a Gi/o to Multiple Signaling Pathways, Including Phospholipase C Activation, Ca2+Mobilization, Ras-Mitogen-activated Protein Kinase Activation, and Adenylate Cyclase Inhibition

1998 • 279 citations

Sphingosine‐1‐phosphate: signaling inside and out

2000 • 275 citations

Sphingosine Kinase: Biochemical and Cellular Regulation and Role in Disease

2006 • 273 citations

Selective Loss of Sphingosine 1-Phosphate Signaling with No Obvious Phenotypic Abnormality in Mice Lacking Its G Protein-coupled Receptor, LPB3/EDG-3

2001 • 271 citations

Sphingosine 1-Phosphate Analogs as Receptor Antagonists

2004 • 267 citations

Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720

2005 • 263 citations

Inhibitory and Stimulatory Regulation of Rac and Cell Motility by the G_12/13-Rho and G_i Pathways Integrated Downstream of a Single G Protein-Coupled Sphingosine-1-Phosphate Receptor Isoform

2003 • 259 citations

Sphingosine 1-phosphate signalling through the G-protein-coupled receptor Edg-1

1998 • 252 citations

Point-Counterpoint of Sphingosine 1-Phosphate Metabolism

2004 • 251 citations

Lipid phosphate phosphatases and related proteins: Signaling functions in development, cell division, and cancer

2004 • 246 citations

Sphingosylphosphorylcholine and Lysophosphatidylcholine Are Ligands for the G Protein-coupled Receptor GPR4

2001 • 242 citations

Marked Perinatal Lethality and Cellular Signaling Deficits in Mice Null for the Two Sphingosine 1-Phosphate (S1P) Receptors, S1P2/LPB2/EDG-5 and S1P3/LPB3/EDG-3

2002 • 241 citations

G2A Is a Proton-sensing G-protein-coupled Receptor Antagonized by Lysophosphatidylcholine

2004 • 241 citations

TDAG8 Is a Proton-sensing and Psychosine-sensitive G-protein-coupled Receptor

2004 • 241 citations

Emerging medicinal roles for lysophospholipid signaling

2006 • 240 citations

Antitumor Activity of Sphingosine Kinase Inhibitors

2006 • 239 citations

S1P1-Selective In Vivo-Active Agonists from High- Throughput Screening: Off-the-Shelf Chemical Probes of Receptor Interactions, Signaling, and Fate

2005 • 235 citations

EDG6, a Novel G-Protein-Coupled Receptor Related to Receptors for Bioactive Lysophospholipids, Is Specifically Expressed in Lymphoid Tissue

1998 • 231 citations

Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney

2006 • 226 citations

Autotaxin Is Released from Adipocytes, Catalyzes Lysophosphatidic Acid Synthesis, and Activates Preadipocyte Proliferation

2003 • 225 citations

Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate.

2003 • 223 citations

Cell surface receptors in lysophospholipid signaling

2004 • 221 citations

Sphingosine kinase 1 is up‐regulated in colon carcinogenesis

2005 • 218 citations

Sphingosine Kinase 2 Is Required for Modulation of Lymphocyte Traffic by FTY720

2005 • 211 citations

Sphingosylphosphorylcholine and lysophosphatidylcholine: G protein-coupled receptors and receptor-mediated signal transduction

2002 • 209 citations

In vitro and in vivo modulation of vascular barrier integrity by sphingosine 1-phosphate: mechanistic insights

2004 • 207 citations

Sphingosine Kinase 1 Is an Intracellular Effector of Phosphatidic Acid

2004 • 205 citations

Mice Lacking the Orphan G Protein-Coupled Receptor G2A Develop a Late-Onset Autoimmune Syndrome

2001 • 204 citations

Lysophosphatidic Acid Induces Neointima Formation Through PPARγ Activation

2004 • 202 citations

Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradient

2006 • 201 citations

Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors

2002 • 201 citations

Integral membrane lipid phosphatases/phosphotransferases: common structure and diverse functions

2005 • 200 citations

Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells

2005 • 199 citations

Sphingosine Kinase-1 as a Chemotherapy Sensor in Prostate Adenocarcinoma Cell and Mouse Models

2005 • 198 citations

The G-protein-coupled receptors GPR3 and GPR12 are involved in cAMP signaling and maintenance of meiotic arrest in rodent oocytes

2005 • 195 citations

Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death

2000 • 195 citations

T cell chemotaxis to lysophosphatidylcholine through the G2A receptor

2003 • 193 citations

G protein mediated signaling pathways in lysophospholipid induced cell proliferation and survival

2004 • 193 citations

Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells

2001 • 193 citations

Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist

2002 • 191 citations

A novel acylglycerol kinase that produces lysophosphatidic acid modulates cross talk with EGFR in prostate cancer cells

2005 • 188 citations

Identification of T Cell Death-associated Gene 8 (TDAG8) as a Novel Acid Sensing G-protein-coupled Receptor

2004 • 183 citations

Molecular mechanisms of lysophosphatidic acid action

2003 • 181 citations

Proton-sensing and lysolipid-sensitive G-protein-coupled receptors: A novel type of multi-functional receptors

2005 • 180 citations

Ligand-induced Trafficking of the Sphingosine-1-phosphate Receptor EDG-1

1999 • 180 citations

Identification of a Molecular Target of Psychosine and Its Role in Globoid Cell Formation

2001 • 180 citations

Sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P

2003 • 179 citations

Sphingosine-1-phosphate receptors: receptor specificity versus functional redundancy

2004 • 178 citations

Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes

2000 • 177 citations

Sphingosine-1-phosphate is a ligand for the G protein-coupled receptor EDG-6

2000 • 174 citations

Identification and Characterization of a Novel Human Sphingosine-1-phosphate Phosphohydrolase, hSPP2

2003 • 172 citations

Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting shingosine kinase-1

2005 • 172 citations

Gi-independent macrophage chemotaxis to lysophosphatidylcholine via the immunoregulatory GPCR G2A

2004 • 171 citations

Differential transactivation of sphingosine-1-phosphate receptors modulates NGF-induced neurite extension

2004 • 169 citations

Identification of the First Mammalian Sphingosine Phosphate Lyase Gene and Its Functional Expression in Yeast

1998 • 168 citations

Involvement of N-terminal-extended Form of Sphingosine Kinase 2 in Serum-dependent Regulation of Cell Proliferation and Apoptosis

2005 • 166 citations

Role of Human Sphingosine-1-phosphate Phosphatase 1 in the Regulation of Intra- and Extracellular Sphingosine-1-phosphate Levels and Cell Viability

2003 • 161 citations

Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated manner

2005 • 157 citations

Ligand-dependent Inhibition of B16 Melanoma Cell Migration and Invasion via Endogenous S1P2 G Protein-coupled Receptor

2003 • 156 citations

Identification of Edg1 Receptor Residues That Recognize Sphingosine 1-Phosphate

2000 • 155 citations

Edg-6 as a Putative Sphingosine 1-Phosphate Receptor Coupling to Ca2+ Signaling Pathway

2000 • 154 citations

Subtype-Selective Antagonists of Lysophosphatidic Acid Receptors Inhibit Platelet Activation Triggered by the Lipid Core of Atherosclerotic Plaques

2003 • 153 citations

Short-chain phosphatidates are subtype-selective antagonists of lysophosphatidic acid receptors.

2001 • 153 citations

Sphingosine kinase: a mediator of vital cellular functions

2001 • 151 citations

Sphingosine-1-phosphate lyase SPL is an endoplasmic reticulum-resident, integral membrane protein with the pyridoxal 5′-phosphate binding domain exposed to the cytosol

2004 • 150 citations

Sphingosine-phosphate Lyase Enhances Stress-induced Ceramide Generation and Apoptosis

2004 • 147 citations

Sphingosine Kinase Type 1 Induces G12/13-mediated Stress Fiber Formation, yet Promotes Growth and Survival Independent of G Protein-coupled Receptors

2003 • 147 citations

Lysophosphatidic Acid Inhibits Adipocyte Differentiation via Lysophosphatidic Acid 1 Receptor-dependent Down-regulation of Peroxisome Proliferator-activated Receptor γ2

2005 • 143 citations

Type 4 sphingosine 1‐phosphate G protein‐coupled receptor (S1P₄) transduces S1P effects on T cell proliferation and cytokine secretion without signaling migration

2005 • 141 citations

Premature ovarian aging in mice deficient for Gpr3

2005 • 138 citations

Vascular sphingosine-1-phosphate S1P1 and S1P3 receptors

2004 • 137 citations

The Immune Modulator FTY720 Inhibits Sphingosine-1-phosphate Lyase Activity

2005 • 137 citations

Cardiovascular effects of sphingosine‐1‐phosphate and other sphingomyelin metabolites

2004 • 137 citations

Sphingosine 1-phosphate signaling: providing cells with a sense of direction

2002 • 136 citations

Sphingosine kinase activity counteracts ceramide-mediated cell death in human melanoma cells: role of Bcl-2 expression

2005 • 136 citations

Human sphingosine kinase: molecular cloning, functional characterization and tissue distribution

2000 • 133 citations

Sphingolipids and the Balancing of Immune Cell Function: Lessons from the Mast Cell

2005 • 130 citations

The role of sphingosine-1-phosphate in smooth muscle contraction

2004 • 127 citations

Sphingosine 1-Phosphate and Platelet-derived Growth Factor (PDGF) Act via PDGFβ Receptor-Sphingosine 1-Phosphate Receptor Complexes in Airway Smooth Muscle Cells

2003 • 126 citations

The sphingosine 1‐phosphate receptor S1P₄ regulates cell shape and motility via coupling to G_i and G_12/13

2003 • 125 citations

Regulation of immunity by lysosphingolipids and their G protein–coupled receptors

2004 • 124 citations

The sphingosine and diacylglycerol kinase superfamily of signaling kinases: localization as a key to signaling function

2006 • 124 citations

Sphingosine 1-phosphate as a therapeutic agent

2002 • 124 citations

S1P1-selective agonist, SEW2871, ameliorates ischemic acute renal failure

2006 • 123 citations

Immunomodulator FTY720 Induces eNOS-Dependent Arterial Vasodilatation via the Lysophospholipid Receptor S1P ₃

2005 • 122 citations

Identification of a Phosphothionate Analogue of Lysophosphatidic Acid (LPA) as a Selective Agonist of the LPA3 Receptor

2003 • 121 citations

Characterization of lysophosphatidic acid and sphingosine‐1‐phosphate‐mediated signal transduction in rat cortical oligodendrocytes

2003 • 121 citations

Nrg-1 Belongs to the Endothelial Differentiation Gene Family of G Protein-coupled Sphingosine-1-phosphate Receptors

2001 • 121 citations

Lysophosphatidylcholine impairs endothelial barrier function through the G protein-coupled receptor GPR4

2006 • 118 citations

Splyregulation of sphingolipid signaling molecules is essential for Drosophila development

2003 • 114 citations

Thrombogenic and atherogenic activities of lysophosphatidic acid

2004 • 114 citations

Regulation of immunity by lysosphingolipids and their G protein–coupled receptors

2004 • 112 citations

Role of the G-Protein-Coupled Receptor GPR12 as High-Affinity Receptor for Sphingosylphosphorylcholine and Its Expression and Function in Brain Development

2003 • 111 citations

A Single Amino Acid Determines Lysophospholipid Specificity of the S1P1 (EDG1) and LPA1 (EDG2) Phospholipid Growth Factor Receptors

2001 • 110 citations

Targeting sphingosine-1-phosphate: A novel avenue for cancer therapeutics

2006 • 109 citations

Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q2211DNA sequence was deposited in the EMBL database (AJ011304).

2000 • 108 citations

G protein-coupled receptors GPR4 and TDAG8 are oncogenic and overexpressed in human cancers

2004 • 100 citations

Potential involvement of adipocyte insulin resistance in obesity-associated up-regulation of adipocyte lysophospholipase D/autotaxin expression

2005 • 99 citations

Activity of 2-Substituted Lysophosphatidic Acid (LPA) Analogs at LPA Receptors: Discovery of a LPA₁/LPA₃Receptor Antagonist

2001 • 98 citations

Edg-8 receptors are preferentially expressed in oligodendrocyte lineage cells of the rat CNS

2003 • 98 citations

Atheroprotective Effects of High-Density Lipoprotein-Associated Lysosphingolipids

2005 • 96 citations

The epidermal growth factor stimulates sphingosine kinase-1 expression and activity in the human mammary carcinoma cell line MCF7

2005 • 94 citations

Prostaglandin I2 Production and cAMP Accumulation in Response to Acidic Extracellular pH through OGR1 in Human Aortic Smooth Muscle Cells

2005 • 94 citations

G-protein-coupled Receptor Stimulation of the p42/p44 Mitogen-activated Protein Kinase Pathway Is Attenuated by Lipid Phosphate Phosphatases 1, 1a, and 2 in Human Embryonic Kidney 293 Cells

2001 • 94 citations

Physiological responses to lysophosphatidic acid and related glycero-phospholipids

2001 • 93 citations

Antisense Knockdown of Sphingosine Kinase 1 in Human Macrophages Inhibits C5a Receptor-Dependent Signal Transduction, Ca2+ Signals, Enzyme Release, Cytokine Production, and Chemotaxis

2004 • 92 citations

Lipid phosphate phosphatases and lipid phosphate signalling

2005 • 90 citations

Characterization of Murine Sphingosine-1-phosphate Phosphohydrolase

2002 • 86 citations

Evidence for Edg-3 Receptor-Mediated Activation ofI_K.ACh by Sphingosine-1-Phosphate in Human Atrial Cardiomyocytes

2000 • 85 citations

Development of Novel EDG3 Antagonists Using a 3D Database Search and Their Structure−Activity Relationships

2002 • 85 citations

Lysophospholipid receptors in the nervous system.

2002 • 84 citations

Lysophosphatidylcholine-induced Surface Redistribution Regulates Signaling of the Murine G Protein-coupled Receptor G2A

2005 • 83 citations

Molecular basis for lysophosphatidic acid receptor antagonist selectivity

2002 • 83 citations

Novel clusters of receptors for sphingosine‐1‐phosphate, sphingosylphosphorylcholine, and (lyso)‐phosphatidic acid: New receptors for “Old” ligands

2004 • 83 citations

Lysophospholipid receptor‐dependent and ‐independent calcium signaling

2004 • 82 citations

Sphingosine 1-Phosphate in Vascular Biology: Possible Therapeutic Strategies to Control Vascular Diseases

2006 • 81 citations

Fatty Alcohol Phosphates are Subtype-Selective Agonists and Antagonists of Lysophosphatidic Acid Receptors

2003 • 80 citations

Lysophosphatidic acid and sphingosine 1-phosphate biology: the role of lipid phosphate phosphatases

2004 • 80 citations

Lysophospholipid Receptors as Potential Drug Targets in Tissue Transplantation and Autoimmune Diseases

2005 • 79 citations

Expression of and Role for Ovarian Cancer G-protein-coupled Receptor 1 (OGR1) during Osteoclastogenesis

2006 • 79 citations

c-Src is involved in regulating signal transmission from PDGFβ receptor–GPCR(s) complexes in mammalian cells

2004 • 77 citations

GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine

2005 • 77 citations

Cell migration activated by platelet‐derived growth factor receptor is blocked by an inverse agonist of the sphingosine 1‐phosphate receptor‐1

2005 • 76 citations

Negative regulation of endothelial morphogenesis and angiogenesis by S1P2 receptor

2006 • 74 citations

Molecular Cloning, Tissue-Specific Expression, and Chromosomal Localization of a Novel Nerve Growth Factor-Regulated G-Protein-Coupled Receptor, nrg-1

1999 • 73 citations

Normal Immune Development and Glucocorticoid-Induced Thymocyte Apoptosis in Mice Deficient for the T-Cell Death-Associated Gene 8 Receptor

2005 • 73 citations

Selective blockade of lysophosphatidic acid LPA₃receptors reduces murine renal ischemia-reperfusion injury

2003 • 73 citations

FTY720 Pretreatment Reduces Warm Hepatic Ischemia Reperfusion Injury Through Inhibition of T-Lymphocyte Infiltration

2002 • 72 citations

Regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools

2005 • 71 citations

Pulmonary and vascular pharmacology of sphingosine 1-phosphate

2006 • 70 citations

Sphingosine-1-phosphate is a high-affinity ligand for the G protein-coupled receptor GPR6 from mouse and induces intracellular Ca2+ release by activating the sphingosine-kinase pathway

2003 • 70 citations

The G Protein-Coupled Receptor GPR4 Suppresses ERK Activation in a Ligand-Independent Manner

2003 • 69 citations

Sphingosylphosphorylcholine Antagonizes Proton-Sensing Ovarian Cancer G-Protein-Coupled Receptor 1 (OGR1)-Mediated Inositol Phosphate Production and cAMP Accumulation

2005 • 68 citations

Signalling diacylglycerol pyrophosphate, a new phosphatidic acid metabolite

2006 • 68 citations

Novel role of sphingosine kinase 1 as a mediator of neurotrophin‐3 action in oligodendrocyte progenitors

2005 • 68 citations

Sphingosine and Its Analog, the Immunosuppressant 2-Amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol, Interact with the CB₁ Cannabinoid Receptor

2006 • 67 citations

Lipid phosphate phosphatases and lipid phosphate signalling

2005 • 66 citations

Autotaxin expression is enhanced in frontal cortex of Alzheimer-type dementia patients

2006 • 65 citations

The Glucocorticoid-induced Gene tdag8 Encodes a Pro-apoptotic G Protein-coupled Receptor Whose Activation Promotes Glucocorticoid-induced Apoptosis

2004 • 61 citations

Ca2+/calmodulin-dependent translocation of sphingosine kinase: role in plasma membrane relocation but not activation

2003 • 60 citations

Expression of SphK1 impairs degranulation and motility of RBL-2H3 mast cells by desensitizing S1P receptors

2005 • 58 citations

Phytosphingosine 1-phosphate: a high affinity ligand for the S1P4/Edg-6 receptor

2002 • 56 citations

Retraction

2005 • 54 citations

Lysophospholipids in the nervous system

2004 • 54 citations

Identification of functional nuclear export sequences in human sphingosine kinase 1

2003 • 53 citations

Sphingosine kinase signalling in immune cells

2005 • 51 citations

Sphingosine 1‐phosphate promotes cell migration through the activation of Cdc42 in Edg‐6/S1P4‐expressing cells

2003 • 47 citations

Sphingosine 1-phosphate analogue recognition and selectivity at S1P4 within the endothelial differentiation gene family of receptors

2005 • 47 citations

Expression of Ectolipid Phosphate Phosphohydrolases in 3T3F442A Preadipocytes and Adipocytes

2002 • 43 citations

Sphingosine 1-phosphate and lysophosphatidic acid receptors: agonist and antagonist binding and progress toward development of receptor-specific ligands

2004 • 43 citations

Lysophospholipids as Mediators of Immunity

2006 • 39 citations

Sphingolipids in Anticancer Therapy

2006 • 34 citations

Two ligands for a GPCR, proton vs lysolipid1

2005 • 34 citations

Regulated and constitutive activation of specific signalling pathways by the human S1P₅ receptor

2003 • 30 citations

Fluid Shear Stress Differentially Regulates gpr3, gpr6, and gpr12 Expression in Human Umbilical Vein Endothelial Cells

2003 • 30 citations

New metabolically stabilized analogues of lysophosphatidic acid: agonists, antagonists and enzyme inhibitors

2005 • 26 citations

Effect of a membrane-targeted sphingosine kinase 1 on cell proliferation and survival

2005 • 21 citations

A single amino acid determines preference between phospholipids and reveals length restriction for activation of the S1P4 receptor.

2004 • 21 citations

New metabolically stabilized analogues of lysophosphatidic acid: agonists, antagonists and enzyme inhibitors

2005 • 19 citations

A short guide to the nomenclature of seven-transmembrane spanning receptors for lipid mediators

2005 • 18 citations

Withdrawal: Sphingosylphosphorylcholine and lysophosphatidylcholine are ligands for the G protein-coupled receptor GPR4. VOLUME 276 (2001) PAGES 41325-41335

2005 • 16 citations

Pharmacological characterization of human S1P₄ using a novel radioligand, [4,5‐³H]‐dihydrosphingosine‐1‐phosphate

2004 • 12 citations

Use of FTY 720 and ICAM-1 Antisense Oligonucleotides for Attenuating Chronic Renal Damage Secondary to Ischemia-Reperfusion Injury

2005 • 10 citations

Chemical approaches to the lysophospholipid receptors

2004 • 8 citations

Direct observation of G-protein binding to the human δ-opioid receptor using plasmon-waveguide resonance spectroscopy. VOLUME 278 (2003) PAGES 48890-48897

2005 • 6 citations